Assessment of trabecular and cortical parameters using high-resolution peripheral quantitative computed tomography, histomorphometry and microCT of iliac crest bone core in hemodialysis patients

Pichone, Alinie; Gomes, Carlos Perez; Lima, Luis Felipe Cardoso; Moreira, Carolina Aguiar; Paranhos-Neto, Francisco de Paula; Madeira, Miguel; Lopes, Ricardo Tadeu; Farias, Maria Lúcia Fleiuss; Leite, Maurilo

doi:10.1016/j.bonr.2022.101173

Cited by 2 publications

(3 citation statements)

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“…Based on the correlations between histological and radiological findings in other medical fields [ 21 , 23 , 40 , 41 ], we investigated this relationship by studying bone repair processes and root resorptions in our rodent cleft model to determine whether both analytical procedures are necessary for the assessment of structural changes or micro-CT is sufficient. Apart from reproducing our previous findings [ 14 , 15 ], Tb.Th and Tb.Sp changes were now also included in the present follow-up investigation since they represent a feature of histological analysis of the new bone formation.…”

Section: Discussionmentioning

confidence: 99%

“…Micro-CT is an established method for bone analysis in different fields of medicine. Recently, Pichone et al [ 41 ] assessed trabecular and cortical parameters using histomorphometry and micro-CT of the iliac crest bone core in haemodialysis patients, finding a moderate correlation between the techniques in the trabecular bone volume. In different conditions such as osteoporosis, hypoparathyroidism and primary hyperparathyroidism, positive correlations between the two techniques have been documented [ 21 , 23 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

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Correlations between radiological and histological findings of bone remodelling and root resorption in a rodent cleft model

Möhlhenrich

Kniha²,

Heitzer³

et al. 2022

Head Face Med

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Background The evaluation of bone remodelling and dental root resorption can be performed by histological techniques or micro-computed tomography (micro-CT). The present study aimed to evaluate the relationship between these two procedures in the context of cleft repair in a rat model. Methods The reconstructed maxillae and the orthodontically-moved first molar of 12 rats were analysed for correlations between the histological and radiological findings retrospectively. The alveolar cleft repairs were performed using bone autografts or (human) xenografts. Four weeks after the operation, the intervention of the first molar protraction was initiated and lasted for eight weeks. The newly formed bone and the root resorption lacunae were determined via histology. In the micro-CT analysis, the average change of bone mineral density (BMD), bone volume fraction (BV/TV), trabecular thickness and trabecular separation of the jaw, as well as the volume of the root resorptions were determined. The Pearson correlation coefficient was applied to study the associations between groups. Results Positive correlations were found only between the newly formed bone (histology) and BMD changes (micro-CT) in the autograft group (r = 0.812, 95% CI: 0.001 to 0.979, p = 0.05). The relationship of newly formed bone and BV/TV was similar but not statistically significant (r = 0.691, 95% CI: −0.274 to 0.963, p = 0.013). Regarding root resorption, no significant correlations were found. Conclusions Due to the lack of correlation between histological and radiological findings of bone remodelling and the development of root resorptions, both methods should be combined in this cleft model in rats for a comprehensive analysis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Correlations between radiological and histological findings of bone remodelling and root resorption in a rodent cleft model

Möhlhenrich

Kniha²,

Heitzer³

et al. 2022

Head Face Med

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“… 40 The ability of HR-pQCT to categorize CKD-MBD into high- vs low-turnover status was also demonstrated specifically in patients on hemodialysis, in comparison with bone biopsy. 41 …”

Section: Chronic Kidney Diseasementioning

confidence: 99%

High-resolution peripheral quantitative computed tomography: research or clinical practice?

Gazzotti

Gómez

Schileo

et al. 2023

The British Journal of Radiology

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High-resolution peripheral quantitative computed tomography (HR-pQCT) is a low-dose three-dimensional imaging technique, originally developed for in vivo assessment of bone microarchitecture at the distal radius and tibia in osteoporosis. HR-pQCT has the ability to discriminate trabecular and cortical bone compartments, providing densitometric and structural parameters. At present, HR-pQCT is mostly used in research settings, despite evidence showing that it may be a valuable tool in osteoporosis and other diseases. This review summarizes the main applications of HR-pQCT and addresses the limitations that currently prevent its integration into routine clinical practice. In particular, the focus is on the use of HR-pQCT in primary and secondary osteoporosis, chronic kidney disease (CKD), endocrine disorders affecting bone, and rare diseases. A section on novel potential applications of HR-pQCT is also present, including assessment of rheumatic diseases, knee osteoarthritis, distal radius/scaphoid fractures, vascular calcifications, effect of medications, and skeletal muscle. The reviewed literature seems to suggest that a more widespread implementation of HR-pQCT in clinical practice would offer notable opportunities. For instance, HR-pQCT can improve the prediction of incident fractures beyond areal bone mineral density provided by dual-energy X-ray absorptiometry. In addition, HR-pQCT may be used for the monitoring of anti osteoporotic therapy or for the assessment of mineral and bone disorder associated with CKD. Nevertheless, several obstacles currently prevent a broader use of HR-pQCT and would need to be targeted, such as the small number of installed machines worldwide, the uncertain cost-effectiveness, the need for improved reproducibility, and the limited availability of reference normative datasets.

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Assessment of trabecular and cortical parameters using high-resolution peripheral quantitative computed tomography, histomorphometry and microCT of iliac crest bone core in hemodialysis patients

Cited by 2 publications

References 52 publications

Correlations between radiological and histological findings of bone remodelling and root resorption in a rodent cleft model

Correlations between radiological and histological findings of bone remodelling and root resorption in a rodent cleft model

High-resolution peripheral quantitative computed tomography: research or clinical practice?

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