Assessment of topical microbicides to prevent HIV-1 transmission: Concepts, testing, lessons learned

Friend, David R.; Kiser, Patrick F.

doi:10.1016/j.antiviral.2013.06.021

Cited by 47 publications

(49 citation statements)

References 118 publications

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“…The use of topical agents, microbicides, for the prevention of HIV infection has shown promise for prevention of vaginal HIV acquisition [52]. In recent years, there has also been progress in the development of microbicides for rectal use[53].…”

Section: Opportunitiesmentioning

confidence: 99%

HIV epidemics among transgender women

Poteat

Reisner

Radix

2014

Current Opinion in HIV and AIDS

194

149

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Purpose of review Recent data on the high burden of HIV among transgender women has stimulated interest in addressing HIV in this vulnerable population. This review situates the epidemiologic data on HIV among transgender women in the context of the social determinants of health and describes opportunities for effective interventions. Recent findings Transgender women experience unique vulnerability to HIV that can be attributed to multi-level, intersecting factors that also influence the HIV treatment and care continuum. Stigma and discrimination, lack of social and legal recognition of their affirmed gender, and exclusion from employment and educational opportunities represent fundamental drivers of HIV risk in transgender women worldwide. Summary Interventions to improve engagement in HIV prevention, testing, care, and treatment among transgender women should build on community strengths and address structural factors as well as psychosocial and biologic factors that increase HIV vulnerability and prevent access to HIV services.

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Section: Opportunitiesmentioning

confidence: 99%

HIV epidemics among transgender women

Poteat

Reisner

Radix

2014

Current Opinion in HIV and AIDS

194

149

View full text Add to dashboard Cite

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“…ntravaginal rings (IVRs) represent a promising approach to deliver anti-HIV microbicides with the premise to provide optimal drug concentrations for protection over a month or longer and to potentially improve adherence (1)(2)(3)(4)(5)(6)(7). Several IVRs are currently in different stages of development (5,8).…”

mentioning

confidence: 99%

MIV-150-Containing Intravaginal Rings Protect Macaque Vaginal Explants against SHIV-RT Infection

Ouattara

Barnable

Mawson

et al. 2014

Antimicrob Agents Chemother

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“…However, similar to the experience of the use of topical microbicides for the prevention of STIs/HIV 32 , there would be many challenges to fostering both initial uptake and sustained use. Prior microbicide acceptability research shows that women are interested in effective microbicides and have opinions about how and when to use them.…”

Section: Discussionmentioning

confidence: 99%

Attitudes towards microbicide use for bacterial vaginosis in pregnancy

et al. 2014

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Objectives Bacterial vaginosis (BV) is the most common reproductive tract infection (RTI) and is a significant risk factor for preterm birth. Microbicides could be an option for prevention and treatment of BV in pregnancy and understanding use of the product will be crucial to its success. The present study explored attitudes of women in the third trimester of pregnancy regarding topical microbicide use for prevention and treatment of BV. Methods Twenty-six women in their third trimester were interviewed regarding their knowledge and beliefs about RTIs during pregnancy and attitudes concerning the use of topical microbicides for prevention and treatment of BV. Results Participants had a mean age of 24.9 years, were largely underrepresented minorities and the majority had past pregnancies. Participants had knowledge and experience with RTIs but not BV. They were open to the use of microbicides for either prevention or treatment of BV, but believed that women requiring treatment would be more motivated. Rationales for acceptability were most commonly related to the baby's health. Practical issues that may interfere with use were often, but not always, related to pregnancy. There was a range of attitudes about partner involvement in decision-making and the practicalities of product use. Conclusion Pregnant women are knowledgeable about RTIs but not necessarily BV. The women in this study found microbicide use acceptable, particularly for treatment. To improve acceptability and use, education would be needed about BV and possible complications, how to overcome practical problems, and the value of involving partners in the decision.

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Assessment of topical microbicides to prevent HIV-1 transmission: Concepts, testing, lessons learned

Cited by 47 publications

References 118 publications

HIV epidemics among transgender women

HIV epidemics among transgender women

MIV-150-Containing Intravaginal Rings Protect Macaque Vaginal Explants against SHIV-RT Infection

Attitudes towards microbicide use for bacterial vaginosis in pregnancy

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