Assessment of tissue pathology using optical polarimetry

Ali, Zahra; Mahmood, Tariq; Shahzad, Ayesha; Iqbal, Muaz; Ahmad, Iftikhar

doi:10.1007/s10103-021-03450-7

Cited by 10 publications

(3 citation statements)

References 97 publications

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“…This change in the properties of light depends on the physical characteristics of the samples related to polarization: birrefringence, dichroism and depolarization. Historically, polarimetric observables related with birrefringence and dichroism were broadly used for the inspection of biological tissues, 9 whereas depolarization was trying to be minimized. 10 However, one of the depolarization sources is multiple scattering, which due to the high concentration of scattering centres in biological tissues is a predominant effect when light interacts with these samples.…”

Section: Introductionmentioning

confidence: 99%

“…The use of polarimetric observables related to depolarization has increased in the last decades. 9,[11][12][13] Moreover, structural changes in samples due to, for instance, pathologies in different stages produce changes in the sample structure which affect the depolarization response. The most widespread used depolarization parameter for studying depolarization properties of samples is the so-called Depolarization Index (P ∆ ).…”

Section: Introductionmentioning

confidence: 99%

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Enhancing biological tissue structures visualization through polarimetric parameters

Canabal-Carbia

Rodríguez²,

Caride³

et al. 2023

Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023

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Polarimetrical imaging is a noninvasive optical technique of great interest in biophotonics since it has the capability of obtaining relevant information of biological samples, being useful, for instance, for the early detection of diseases or the classification of biological structures, both on animal and vegetal tissues. Different structures produce different outcomes when interacting with light due to their polarimetric properties such as depolarization, dichroism or retardance. An exhaustive polarimetric analysis of these characteristics can unveil the relation between the tissue inherent characteristics and its polarimetric response, enabling us to find the most appropriate polarimetric parameters to describe or study a sample. These polarimetric characteristics can be obtained through the experimental measurement of the Mueller matrix (M) of a sample, from which a range of different polarimetric observables, giving physical interpretation, can be deduced. By taking advantage of these parameters, we propose a study of the suitability of different groups of metrics for the contrast enhancement in biological tissues imaging, taking special attention on some depolarization metrics and some physical parameters such as the wavelength or the angle of incidence of the illumination light. The results obtained suggest the convenience of certain parameters which may be of interest in multiple biomedical scenarios such as pathology early detection or enhanced visualization of different structures for clinical applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancing biological tissue structures visualization through polarimetric parameters

Canabal-Carbia

Rodríguez²,

Caride³

et al. 2023

Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023

View full text Add to dashboard Cite

show abstract

“…In the case of plant samples, this helps in the detection of the organization and concentration of chloroplasts and related organelles in plant species [28]. In [29], the authors provide a list of animal and human samples where different tissue regions and pathologies were inspected by means of imaging polarimetry.…”

Section: Introductionmentioning

confidence: 99%

Polarimetric Images of Biological Tissues Based on the Arrow Decomposition of Mueller Matrices

et al. 2023

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Polarimetric techniques are widely used in a vast number of applications such as remote sensing, material characterization, astronomy and biological tissue inspection. In this last scenario, different polarimetric observables have proved their potential for enhancing imaging visualization. In this work we use a set of polarimetric observables derived from the arrow decomposition of the Mueller matrix for the first time: enpolarizing, retarding and depolarizing descriptors. In particular, the mean intensity coefficient and the three indices of polarimetric purity, the absolute values and Poincaré orientations of diattenuation, polarizance, entrance retardance and exit retardance vectors are considered. Results show images with enhanced visualization or even revealing invisible structures when compared to standard intensity images. In particular, thanks to these metrics, we improve the visualization of the necrotic areas of a Vitis rupestris leaf. In the case of animal samples, boundaries between different fascicles inside a tendon of an ex vivo chicken sample are revealed, as is the directionality of fiber tracts of the subcortical white matter in an ex vivo cow brain. The experimental results show the potential for biophotonics imaging and how polarimetric techniques could be useful for biomedical and botanical applications.

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