Assessment of thyroid function of newly diagnosed SARS-CoV-2 infected patients in Nigeria

Okwor, Chika; Meka, Ijeoma A; Akinwande, Kazeem Sanjo; Edem, Victory Fabian; Okwor, Vitalis C.

doi:10.11604/pamj.2021.40.9.26358

Cited by 8 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Six studies recorded the thyroxine levels of healthy cohorts as control groups (n = 1052). The pooled estimates of TSH, FT3, and FT4 levels were 1.78 (95% CI, [1.56, 2.01]), 4.76 (95% CI, [4.44, 5.08]), and 14.03 (95% CI, [12.93, 15.13]), respectively ( eFigure 3 in the Supplement ) ( 14 , 18 , 36 , 40 – 42 ). Five studies included the thyroxine levels of non-COVID-19 pneumonia patients (n = 269) ( 14 , 18 , 42 – 44 ).…”

Section: Resultsmentioning

confidence: 99%

Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis

Hou²,

Mu³

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveCOVID-19 infection may affect thyroid function. However, changes in thyroid function in COVID-19 patients have not been well described. This systematic review and meta-analysis assess thyroxine levels in COVID-19 patients, compared with non-COVID-19 pneumonia and healthy cohorts during the COVID-19 epidemic.MethodsA search was performed in English and Chinese databases from inception to August 1, 2022. The primary analysis assessed thyroid function in COVID-19 patients, comparing non-COVID-19 pneumonia and healthy cohorts. Secondary outcomes included different severity and prognoses of COVID-19 patients.ResultsA total of 5873 patients were enrolled in the study. The pooled estimates of TSH and FT3 were significantly lower in patients with COVID-19 and non-COVID-19 pneumonia than in the healthy cohort (P < 0.001), whereas FT4 were significantly higher (P < 0.001). Patients with the non-severe COVID-19 showed significant higher in TSH levels than the severe (I2 = 89.9%, P = 0.002) and FT3 (I2 = 91.9%, P < 0.001). Standard mean differences (SMD) of TSH, FT3, and FT4 levels of survivors and non-survivors were 0.29 (P= 0.006), 1.11 (P < 0.001), and 0.22 (P < 0.001). For ICU patients, the survivors had significantly higher FT4 (SMD=0.47, P=0.003) and FT3 (SMD=0.51, P=0.001) than non-survivors.ConclusionsCompared with the healthy cohort, COVID-19 patients showed decreased TSH and FT3 and increased FT4, similar to non-COVID-19 pneumonia. Thyroid function changes were related to the severity of COVID-19. Thyroxine levels have clinical significance for prognosis evaluation, especially FT3.

show abstract

Section: Resultsmentioning

confidence: 99%

Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis

Hou²,

Mu³

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…A study conducted in Nigerian population revealed that serum T3 and TSH concentrations were significantly higher in COVID 19 patients as compared to controls. 15.6% population had sick euthyroid and 6.7% had subclinical hypothyroidism 20 . A single centre retrospective study from Pakistan provided solid evidence of altered thyroid function due to pneumonia associated with Covid 19.…”

Section: Discussionmentioning

confidence: 97%

Association of Hypothyroidism and Subclinical Hypothyroidism with Covid-19 infection: A cross sectional study

Gardezi,

Tirmizi,

Avais

et al. 2023

PJMHS

View full text Add to dashboard Cite

Background: A complex relationship of viral infections and the functionality of thyroid gland mainly due to a complex role of immunomodulatory signaling molecules, receptors and hormones. Aim: To check the Association of Hypothyroidism and Subclinical Hypothyroidism with Covid 19 infection. Study Design: Cross sectional study. Methodology: 100 patients presenting to emergency and medical OPDs or already admitted with Covid 19 infections were enrolled into the study. Only those admitted patients whose previous reports of thyroid profile were available and showed no anomaly, were included in the study. Presence of SARS-Cov-2 was confirmed using nasal or throat swab using reverse transcriptase polymerase chain reaction. 3ml blood sample was taken from the anticubital fossa of the patients under sterile conditions in Gel tube containing clot activator. Thyroid function tests of patients were carried out in automated analyzer by chemiluminescence method. Data was analyzed using SPSS version 25.0. Results: Out of total 100 patients 60 (60%) were male and 40 (40%) were females. Mean age of the patients was 40.6 ± 10.5 years. 54 (54%) of the patients had normal T3 levels where as 46 (46%) of the patients had below normal T3 levels. 47(47%) of the patients had lower T4 levels. TSH levels were normal in 50 (50%) patients whereas 35 (35%) had reduced levels and 15(15%) had raised levels. Mean T3 levels of study population was 2.04 ±1.1 pg/ml (0.1-4.1), T4 levels were 0.93 ±0.50 ng/dl (0.1-1.7) and TSH levels were 2.5 ±2.1 mIU/L (0.1-8.1). Prevalence of hypothyroidism was greater in our Covid population under study. 2 (2%) patients were diagnosed as having subclinical hypothyroidism. Conclusion: Presence and development of Hypothyroidism is significantly associated with SARs-Cov-2 viral infection. It has prognostic and diagnostic significant. Practical Implication: Due to the emerging nature of the COVID-19 crisis, this study helped researchers to investigate the functionality of thyroid gland due to Covid-19 infection. Keywords: Covid 19, endocrine disorder, hypothyroidism, Serum T3, T4, Thyroid gland, thyroid stimulating hormone.

show abstract

“… 6 Abnormal thyroid function was common in patients with COVID-19, particularly hyperthyroidism in another study. 7 , 15 …”

Section: Discussionmentioning

confidence: 99%

“…6 Abnormal thyroid function was common in patients with COVID-19, particularly hyperthyroidism in another study. 7,15 The patients with hypothyroidism and subclinical hypothyroidism were more likely to be female. 16 The reasons for this gender disparity in the prevalence of thyroid disorders are not completely understood.…”

Section: Discussionmentioning

confidence: 99%

Subclinical Hypothyroidism among Patients with COVID-19 Infection in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Adhikari

Singh

2023

J Nepal Med Assoc

View full text Add to dashboard Cite

Introduction: Hypothyroidism occurs as a consequence of chronic autoimmune inflammation of the thyroid gland, which occurs due to the reduced function in the secretion of thyroid hormones. The coronavirus disease infection has shown many complications in all organic systems, during the acute phase of infection and in the post-COVID-19 period. SARS-CoV-2 may induce thyroid dysfunction that is usually reversible, including subclinical and atypical thyroiditis. The aim of this study was to find out the prevalence of subclinical hypothyroidism among patients with COVID-19 infection in a tertiary care centre. Methods: A descriptive cross-sectional study was conducted in the Department of Internal Medicine of a tertiary care centre from 1 September 2022 to 28 February 2023 after obtaining ethical approval from the Research and Institutional Review Committee (Reference number: 15-079/080). Convenience sampling method was used. Point estimate and 95% Confidence Interval were calculated. Results: Among 38 patients with COVID-19, subclinical hypothyroidism was seen among 23 (60.53%) (44.99-76.07, 95% Confidence Interval). Conclusions: The prevalence of subclinical hypothyroidism among COVID-19 patients was found to be similar to other studies done in similar settings.

show abstract

Assessment of thyroid function of newly diagnosed SARS-CoV-2 infected patients in Nigeria

Cited by 8 publications

References 24 publications

Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis

Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis

Association of Hypothyroidism and Subclinical Hypothyroidism with Covid-19 infection: A cross sectional study

Subclinical Hypothyroidism among Patients with COVID-19 Infection in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Contact Info

Product

Resources

About