Assessment of thiol/disulphide homoeostasis and ischaemia-modified albumin and their relationship with disease severity in children with chronic urticaria

Akdag, Songul; Özmen, Serap; Ercan, Nazlı; Bostancı, İlknur; Neşeli̇oğlu, Salim

doi:10.1080/15569527.2020.1790589

Cited by 7 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we did not notice changes in the level of binding to albumin in both AD and CU, which may indicate that this protein is not damaged by oxidative stress. However, patients with acute urticaria or CU showed a reduced ability of serum albumin to bind cobalt ions compared to healthy controls, which could result from the inflammatory response induced by oxidative stress [ 47 , 58 , 59 ]. Similarly, patients with psoriasis revealed a lower ability of albumin to bind ions than healthy controls, which might be produced through an adaptive response to chronic hypoxia and oxidative stress, which might play a role in the systemic inflammation seen in psoriasis [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

et al. 2022

View full text Add to dashboard Cite

Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence and pathogenesis that are not fully understood. Emerging evidence suggests that oxidative stress plays a role in AD and CU. The aim of the single-center cross-sectional study was to compare markers of oxidative stress in 21 patients with AD, and 19 CU patients. The products of protein oxidation, total antioxidant capacity (TAC), and markers of lipid peroxidation were estimated in the serum. AD patients had a higher level of advanced protein oxidation products and a lower level of thiol groups than healthy participants. However, CU patients had statistically higher levels of AOPP and 3-nitrotyrosine than healthy subjects. The level of thiol groups and serum TAC decreased significantly in patients with CU. There was no difference in serum concentration of lipid peroxidation products, Amadori products, ratio of reduced to oxidized glutathione, and ability of albumin to binding cobalt between AD or CU patients compared to healthy subjects. We found a moderate positive significant correlation between AOPP and age in patients with AD. In patients with CU, TAC was negatively correlated with age. These results may shed light on the etiopathogenesis of AD or CU, and confirm an oxidative burden in these patients. Furthermore, our study could be useful in developing new therapeutic methods that include using antioxidants in dermatological diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Altered TDH and increased IMA levels in children with chronic urticaria have shown that oxidative stress can play a role in disease pathogenesis. SS and IMA levels were increased in patient group while native thiol levels were decreased 14 . In other studies carried out in acne vulgaris and psoriasis, IMA levels were also found to be significantly high 13,15,35 .…”

Section: Discussionmentioning

confidence: 57%

“…The formation of reactive oxygen species (ROS) and free radicals changes the N‐terminal binding site of albumin temporarily which in turn causes an increase in IMA concentration 12 . Alterations in IMA levels have been reported in several dermatological diseases 13–15 . The present study aims to investigate the relationship between TDH, IMA, and Hidradenitis Supurativa.…”

Section: Introductionmentioning

confidence: 98%

Investigation of thiol‐disulfide homeostasis and ischemia‐modified albumin levels in patients with hidradenitis supurativa

Balik¹,

Balık²,

Yücel³

et al. 2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. The pathogenesis of HS is not clear, and the triggering mechanism for the initiation of the disease is still a controversy. Aims The present study aims to investigate the relationship between thiol‐disulfide homeostasis (TDH), ischemia‐modified albumin (IMA), and HS. To our knowledge, this will be the first report evaluating TDH and IMA status in HS. Patients/Methods The study included 30 patients with HS as the patient group and 30 healthy individuals as the control group. For determination of HS severity, Hurley and Hidradenitis suppurativa physician global assessment (PGA) scores were used. One tube venous blood specimen from every participant was obtained. IMA and TDH tests were analyzed in sera of participants. The results were evaluated statistically. Results Disulfide (p < 0.001), Index I (p = 0.001), and Index II (p = 0.001) levels in HS group were significantly higher than control group. IMA levels in patients with higher Hurley scores are significantly higher (p = 0.032, r = 0.39). A positive correlation was observed between IMA level and disease duration (p = 0.021, r = 0.42). Conclusions The shift in thiol/disulfide balance toward disulfide and significant increase in IMA levels put out the importance of oxidation status in HS etiopathogenesis.

show abstract

“…Sener et al reported that disulfide levels were increased in patients with rosacea 17 . Akdag et al, in a study with chronic urticaria patients, found that native thiol and total thiol levels significantly decreased 18 . Another study revealed higher levels of native thiol and total thiol and lower levels of disulfide in atopic dermatitis 8 .…”

Section: Discussionmentioning

confidence: 97%

Assessment of dynamic thiol-disulfide homeostasis in patients with lipoid proteinosis (Urbach-Wiethe syndrome)

Taskin

Çelik

Taşkın

et al. 2022

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

OBJECTIVE: Lipoid proteinosis is a rare autosomal recessive genetic dermatological disease that occurs due to the accumulation of hyaline material in the skin and mucous membranes. This study aimed to investigate whether dynamic thiol-disulfide homeostasis is a new marker of oxidative stress in patients suffering from lipoid proteinosis. METHODS: The study group involved 17 patients with lipoid proteinosis and 17 healthy controls with same gender and age. Native thiol, total thiol, disulfide levels, and thiol-disulfide indexes were measured with the fully automated spectrophotometric method described by Erel and Neselioglu, and the results of the two groups were statistically analyzed. RESULTS: Serum total thiol and native thiol levels were significantly lower in lipoid proteinosis group compared to the control group (p=0.020 and p=0.014, respectively). The disulfide levels were found to be higher in lipoid proteinosis group, but there was no significant difference between two groups. CONCLUSIONS: Impaired dynamic thiol-disulfide homeostasis was observed in lipoid proteinosis patients, suggesting that thiol-disulfide homeostasis may have a role in the pathogenesis of this disease.

show abstract

Assessment of thiol/disulphide homoeostasis and ischaemia-modified albumin and their relationship with disease severity in children with chronic urticaria

Cited by 7 publications

References 25 publications

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

Investigation of thiol‐disulfide homeostasis and ischemia‐modified albumin levels in patients with hidradenitis supurativa

Assessment of dynamic thiol-disulfide homeostasis in patients with lipoid proteinosis (Urbach-Wiethe syndrome)

Contact Info

Product

Resources

About