Assessment of therapeutic efficacy of miR-126 with contrast-enhanced ultrasound in preeclampsia rats

Yan, Ting; Cui, Kai; Huang, Xiaowei; Ding, Shan; Zheng, Yongqiang; Luo, Qiang; Liu, X.; Zou, Li

doi:10.1016/j.placenta.2013.10.017

Cited by 29 publications

(34 citation statements)

References 41 publications

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“…A recent study has assessed the therapeutic efficacy of miR-126, a pro-angiogenic miRNA, in reversing the inadequate vasculogenesis that occurs in pre-eclampsia. 129 In a pre-eclamptic rat model, miR-126 replacement therapy by agomiR-126 increased placental area, weight and microvessel density compared to saline-injected control animals. 129 The underexpression of VEGF-targeting miRNAs in pathologies associated with abundant angiogenesis and the overexpression of miRNAs in pathologies associated with insufficient angiogenesis suggest important roles for miRNAs in controlling angiogenesis.…”

Section: Microrna Regulation Of Angiogenesismentioning

confidence: 99%

MicroRNAs, immune cells and pregnancy

et al. 2014

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MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that are expressed in many cell types, where they regulate the expression of complementary RNAs, thus modulating the stability and translation of mRNAs. miRNAs are predicted to regulate the expression of ,50% of all protein coding genes in mammals. Therefore, they participate in virtually all cellular processes investigated so far. Altered miRNAs expressions are associated with both physiological (pregnancy) and pathological processes (cancer). As the dynamic maternal-fetal interface plays a critical role in the maintenance of successful pregnancy, it is not surprising that the miRNAs that are unique to reproductive tissues are abundantly expressed. Research in this field has demonstrated the presence and dysregulation of a distinct set of pregnancy-associated miRNAs; however, most studies have centered on localizing various miRNAs in reproductive microdomains associated with normal or complicated pregnancies. Although several independent miRNA regulatory mechanisms associated with endometrial receptivity, immune cells, angiogenesis and placental development have been studied, miRNA-mediated regulation of pregnancy remains poorly understood. This review provides a summary of the current data on miRNA regulation as well as functional profiles of miRNAs that are found in the uterus, in immune cells associated with maternal tolerance to the fetus, and those involved in angiogenesis and placental development.

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Section: Microrna Regulation Of Angiogenesismentioning

confidence: 99%

MicroRNAs, immune cells and pregnancy

et al. 2014

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“…miR-378c, which was also found to be regulated in the placentas of preeclamptic women, promotes migration and proliferation of extravillous trophoblasts by targeting Nodal ). In addition, an agomir of miR-126, an angiogenic miRNA produced by endothelial cells, was recently shown to ameliorate hypertension, improve placental perfusion, and enhance fetal and placental weight in a rat model of preeclampsia, possibly acting by stimulating the PI3K-Akt pathway (Yan et al 2014). Other miRNAs were shown to be regulated in placentas from preeclamptic women.…”

Section: Placental Disorders and Mirnasmentioning

confidence: 99%

The Function of TrophomiRs and Other MicroRNAs in the Human Placenta

Sadovsky

Mouillet

Ouyang

et al. 2015

Cold Spring Harb Perspect Med

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In eutherian organisms, the placenta interfaces the fetal and maternal environments. Located at the placental villous surface, in direct contact with maternal blood, is the trophoblast layer, which mediates the crucial maternal-fetal exchange of gases, nutrients, and waste products, produces hormones that support the pregnancy, and provides immunologic defense. Discovery of microRNAs (miRNAs) and their role in development, differentiation, and homeostatic resilience has increased our understanding of genomic and epigenomic networks that regulate placental function. Moreover, unique miRNA species, which are expressed by human trophoblasts and are termed ‘trophomiRs’, may exhibit specialized functions during normal and pathological pregnancies. Placental miRNAs, packaged within exosomes and other vesicles or bound in protein complexes, are capable of communicating distinctive signals to maternal and/or fetal tissues. Additional research may usher in the use of circulating miRNAs as pregnancy-related disease biomarkers, providing new diagnostic and therapeutic options during pregnancy.

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“…In macaques during early pregnancy, CEU and Doppler were combined to calculate blood flow in a manually identified ROI and subsequently quantify volume (mL/100 mL), flow rate (s-1) and blood flow (mL/min/g) (Keator et al 2011). Finally, in rats, CEU has been used for quantitative analysis of placental perfusion through the visualisation of the central arterial canal (Zhou et al 2013) and to compare uteroplacental perfusion between controls and a rat model of PE (Yan et al 2014).…”

Section: Contrast-enhanced Ultrasound (Ceu)mentioning

confidence: 99%

Non-invasive evaluation of placental blood flow: lessons from animal models

Mourier¹,

Tarrade²,

Duan³

et al. 2017

Reproduction

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In human obstetrics, placental vascularisation impairment is frequent as well as linked to severe pathological events (preeclampsia and intrauterine growth restriction), and there is a need for reliable methods allowing non-invasive evaluation of placental blood flow. Uteroplacental vascularisation is complex, and animal models are essential for the technical development and safety assessment of these imaging tools for human clinical use; however, these techniques can also be applied in the veterinary context. This paper reviews how ultrasound-based imaging methods such as 2D and 3D Doppler can provide valuable insight for the exploration of placental blood flow both in humans and animals and how new approaches such as the use of ultrasound contrast agents or ultrafast Doppler may allow to discriminate between maternal (non-pulsatile) and foetal (pulsatile) blood flow in the placenta. Finally, functional magnetic resonance imaging could also be used to evaluate placental blood flow, as indicated by studies in animal models, but its safety in human pregnancy still requires to be confirmed. Reproduction (2017) 153 R85-R96

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Assessment of therapeutic efficacy of miR-126 with contrast-enhanced ultrasound in preeclampsia rats

Cited by 29 publications

References 41 publications

MicroRNAs, immune cells and pregnancy

MicroRNAs, immune cells and pregnancy

The Function of TrophomiRs and Other MicroRNAs in the Human Placenta

Non-invasive evaluation of placental blood flow: lessons from animal models

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