Assessment of the zonal variation of perfusion parameters in the femoral head: a 3-T dynamic contrast-enhanced MRI pilot study

Budzik, Jean-François; Lefebvre, G.; Behal, Hélène; Verclytte, Sébastien; Hardouin, Pierre; Teixeira, Pedro Augusto Gondim; Cotten, Anne

doi:10.1007/s00256-017-2802-7

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…The higher variation in fat content found in the inter-trochanteric region could be related to the relatively high hematopoietic marrow content in the proximal femoral metaphysis compared to epiphyseal and apophyseal areas which tend to be predominantly fatty 30 . This difference could be related to other factors not associated with patient sex, such as mechanical stress loading which may influence bone marrow perfusion (and secondarily adiposity) in the femoral epiphysis 31 . Hence, to allow inter-patient comparisons, PDFF assessment should be performed in similar anatomic locations.…”

Section: Discussionmentioning

confidence: 99%

Proximal femur fat fraction variation in healthy subjects using chemical shift-encoding based MRI

Teixeira

Cherubin

Badr³

et al. 2019

Sci Rep

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The objective of this study was to describe the normal variation of bone marrow fat content in the proximal femur considering the influence of side, age, sex and body mass index using fat fraction MRI. From September 2012 to July 2016, the MRI of 131 patients (258 hips) considered to have a normal MRI appearance were retrospectively evaluated. Patient records were searched to allow calculation of the body mass index (BMI). Water-fat based chemical shift MRI was available for all patients included. Proton density fat fraction maps were calculated, and measurements were performed in the femoral epiphysis, intertrochanteric region, and greater trochanter. The influence of patient age, sex, hip side and BMI on fat fraction values was assessed. Fat fraction was significantly different in the different locations evaluated (P = 0.0001). Patient sex and age significantly influenced fat fraction values in all regions evaluated (P < 0.02) with the exception of the epiphysis for sex (p = 0.07). In all locations, PDFF values were higher in men compared to women (3.3%, 4.4% and 13.1% higher in the epiphysis, greater trochanter and intertrochanteric region respectively). The intertrochanteric region presented the lowest fat fraction values with the highest variation compared to the greater trochanter and the epiphysis. BMI only influenced fat fraction values in the intertrochanteric region of females over 42 years old (P = 0.014). The interobserver variability of the measurements performed was considered to be excellent (ICC = 0.968). In conclusion, patient sex, age, and measurement location significantly influenced fat fraction values indicating that specific standards of reference are needed depending on these factors.

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Section: Discussionmentioning

confidence: 99%

Proximal femur fat fraction variation in healthy subjects using chemical shift-encoding based MRI

Teixeira

Cherubin

Badr³

et al. 2019

Sci Rep

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“…prognosis, and provides a basis for choosing between available therapeutic options 1 . It also offers the interesting combination of being able to measure bone marrow fat (BMF) 17 through sequences such as chemical shift imaging (CSI), and to assess bone micro-vascular exchanges (also known as bone perfusion) through sequences such as dynamic contrast-enhanced (DCE)-MRI, thus providing in vivo insight in known/suspected actors of ONFH 7,[18][19][20] .…”

Section: Magnetic Resonance Imaging (Mri) Is the Reference Imaging Te...mentioning

confidence: 99%

Subchondral involvement in osteonecrosis of the femoral head: insight on local composition, microstructure and vascularization

Pascart

Falgayrac

Cortet

et al. 2022

Osteoarthritis and Cartilage

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7T bone perfusion imaging of the knee using arterial spin labeling MRI

Johnson

Ellermann

2019

Magnetic Resonance in Med

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PurposeTo evaluate the feasibility of arterial spin labeling (ASL) imaging of epiphyseal bone marrow in the distal femoral condyle of the knee at 7T MRI.MethodsThe knees of 7 healthy volunteers were imaged with ASL using a 7T whole body MRI scanner and a 28‐channel knee coil. ASL imaging used a flow‐sensitive alternating inversion recovery method for labeling and a single‐shot fast spin echo sequence for image readout. ASL imaging with a single oblique transverse slice was performed at 2 slice positions in the distal femoral condyle. Blood flow was measured in 2 regions of interest: the epiphyseal bone marrow and the overlying patellofemoral cartilage. To analyze perfusion SNR, 200 noise images were also acquired using the same ASL imaging protocol with RF pulses turned off.ResultsKnee bone marrow perfusion imaging was successfully performed with all volunteers. The overall mean of blood flow in the knee bone marrow was 32.90 ± 2.41 mL/100 g/min, and the blood flow was higher at the more distal slice position. We observed significant B0 and inhomogeneities, which need to be addressed in the future to improve the quality of ASL imaging and increase the reliability of knee bone marrow perfusion measurements.ConclusionBone marrow perfusion imaging of the distal femoral condyle is feasible using ASL at 7T. Further technical development is needed to improve the ASL method to overcome existing challenges.

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Assessment of the zonal variation of perfusion parameters in the femoral head: a 3-T dynamic contrast-enhanced MRI pilot study

Abstract: The perfusion of femoral head subchondral bone assessed with dynamic contrast-enhanced magnetic resonance imaging is not homogeneous: the areas exposed to more mechanical loading are less perfused.

Cited by 6 publications

References 30 publications

Proximal femur fat fraction variation in healthy subjects using chemical shift-encoding based MRI

Proximal femur fat fraction variation in healthy subjects using chemical shift-encoding based MRI

Subchondral involvement in osteonecrosis of the femoral head: insight on local composition, microstructure and vascularization

7T bone perfusion imaging of the knee using arterial spin labeling MRI

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