Assessment of the Xpert MTB/RIF assay for diagnosis of tuberculosis with gastric lavage aspirates in children in sub-Saharan Africa: a prospective descriptive study

Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: A systematic review and meta-analysis

“…Four children identified as drug-sensitive by culture had indeterminate Xpert rifampicinresistance results. A meta-analysis of three studies (one being Walters' unpublished study), 12,18 collectively including 176 participants, showed a pooled sensitivity of 86% (95% credible interval 53-98) and a pooled specificity of 98% (94-100) for rifampicinresistance.…”

Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: A systematic review and meta-analysis

“…We selected 15 studies for inclusion (figure 1). [12][13][14][15][16][17][18][19][20][21][22][23][24][25] Five studies were done in low-income countries, two in lower middle-income, six in upper middle-income, and two in high-income countries (table 1). 26 12 studies were done at tertiary, university, or research facilities.…”

A Boy with Disseminated Tuberculosis

“…It can involve pulmonary as well as extrapulmonary sites mainly affecting the organs and systems such as lungs, abdomen, and central nervous system. New molecular diagnostic tests and non-sputum specimens have been recommended for accurate and rapid diagnosis of childhood tuberculosis because delay in the diagnosis and treatment can result in rapid progression of the disease with debilitating consequences in infants and young children [6,7]. The patient that we have reported was affected by Mycobacterium tuberculosis infection involving the lungs, kidneys, intestines, mesenteric lymph nodes and central nervous system.…”

“…Consequently, recent tuberculosis research has focused on development of molecular diagnostic technologies such as XPERT MTB/RIF assay and alternative specimens such as gastric lavage or aspirate for diagnosis of childhood tuberculosis [6,7].…”