Assessment of the variability in the anatomical position and size of the subthalamic nucleus among patients with advanced Parkinson’s disease using magnetic resonance imaging

Daniluk, Slawomir; Davies, Keith G.; Ellias, Samuel; Novák, Péter; Nazzaro, Jules M.

doi:10.1007/s00701-009-0514-z

Cited by 67 publications

(77 citation statements)

References 23 publications

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“…In contrast, the direct targeting method employs stereotactic pre-operative MRI for the visualization and localization of the target structure. As the subthalamic region varies considerably in position and size [35,36] , the individually optimal electrode position can be achieved.…”

Section: Deep Brain Stimulation (Dbs)mentioning

confidence: 99%

Imaging for deep brain stimulation: The zona incerta at 7 Tesla

Kerl

Gerigk²,

Brockmann³

et al. 2013

WJR

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AIM:To evaluate different promising magnetic resonance imaging (MRI) methods at 7.0 Tesla (T) for the pre-stereotactic visualization of the zona incerta (ZI). METHODS:Two neuroradiologists qualitatively and quantitatively examined T2-turbo spin-echo (T2-TSE), T1-weighted gradient-echo, as well as FLASH2D-T2Star and susceptibility-weighted imaging (SWI) for the visualization of the ZI at 7.0 T MRI. Delineation and image quality for the ZI were independently examined using a 6-scale grading system. Inter-rater reliability using Cohen's kappa coefficient (κ ) were assessed. Contrast-tonoise ratios (CNR), and signal-to-noise ratios (SNR) for the ZI were calculated for all sequences. Differences in delineation, SNR, and CNR between the sequences were statistically assessed using a paired t -test. For the anatomic validation the coronal FLASH2D-T2Star images were co-registered with a stereotactic atlas (Schaltenbrand-Wahren). RESULTS:The rostral part of the ZI (rZI) could easily be identified and was best and reliably visualized in the coronal FLASH2D-T2Star images. The caudal part was not definable in any of the sequences. No major artifacts in the rZI were observed in any of the scans. FLASH2D-T2Star and SWI imaging offered significant higher CNR values for the rZI compared to T2-TSE images (P > 0.05). The co-registration of the coronal FLASH2D-T2Star images with the stereotactic atlas schema (Schaltenbrand-Wahren) confirmed the correct localization of the ZI in all cases.CONCLUSION: FLASH2D-T2Star imaging (particularly coronal view) provides the reliable and currently optimal visualization of the rZI at 7.0 T. These results can facilitate a better and more precise targeting of the caudal part of the ZI than ever before.

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Section: Deep Brain Stimulation (Dbs)mentioning

confidence: 99%

Imaging for deep brain stimulation: The zona incerta at 7 Tesla

Kerl

Gerigk²,

Brockmann³

et al. 2013

WJR

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show abstract

“…In our study, the atlas was not distorted so that the AC-PC distance remained fixed to 26 mm. For the lateral direction, there is strong correlation between ventricular width and the laterality of the hypointense zone reflecting the STN in MR images [8]. Therefore, to account for the variability in ventricular width of the patients' brain, the atlas was shifted in lateral direction for an alignment with the individual brain at the thalamo-ventricular border.…”

Section: Inter-individual Variability In Lateral Directionmentioning

confidence: 99%

“…Apart from MCP, which is used to align the atlas with the patient's brain, there are a number of landmarks, which are known to correlate with selected features of the STN [8]. On this basis the Yelnik Atlas [23] is deformed to adapt to each individual patient brain [1].…”

Section: Adaptation Of the Mean Atlas To Landmarksmentioning

confidence: 99%

“…On this basis the Yelnik Atlas [23] is deformed to adapt to each individual patient brain [1]. However, the correlation with most landmarks is rather low [8] and each deformation of the atlas introduces a new variable that must be justified.…”

Section: Adaptation Of the Mean Atlas To Landmarksmentioning

confidence: 99%

“…We have therefore restricted ourselves to the parameter "ventricular width", which is readily available and shows the highest correlation (0.73) with STN laterality [8]. We adjusted for the ventricular width of the patients to normalize the laterality of the STN.…”

Section: Adaptation Of the Mean Atlas To Landmarksmentioning

confidence: 99%

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Stimulation sites in the subthalamic nucleus projected onto a mean 3-D atlas of the thalamus and basal ganglia

Sarnthein¹,

Péus²,

Baumann‐Vogel³

et al. 2013

Acta Neurochir

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A Novel Method for Constructing Histological Section Datasets of the Basal Ganglia in Digitized Human Brain

Xie

Rong

2017

The Anatomical Record

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To investigate the construction of the histological section datasets in the basal ganglia of digitized human brain to provide a reference for the meso-level histological data acquisition. A fresh adult brain from a cadaver with no neurological disease was selected, and tissue blocks of the basal ganglia in the right hemisphere was extracted using the visualization method, followed by pretreatments including gradient dehydrating, gelatin-embedding and setting of calibration points. And then the tissue blocks was cryosectioned into 60-μm-thick coronal sections and the sectional images were captured simultaneously by a digital camera at a fixed position. Two series of sections (one section out of ten) were Nissl-stained with Toluidine blue and immunostained with the calbindin D-28K, respectively. Stained sections were digitized by a high resolution scanner. After alignment and registration, contours of nuclei and different nucleic function divisions in the digital images of stained sections were identified, and then were segmented and labeled using software exploited by ourselves. Datasets of one set of registrated serial sectional images and two sets of registrated histochemically stained images in basal ganglia area were obtained, which provide a histological reference for the neurosurgery and diagnostic imaging. a systematic method of cutting, slicing, staining, data acquisition and image registration of large tissue blocks was established, providing a reference for histological data acquisition on the digital human. Anat Rec, 300:1011-1021, 2017. © 2016 Wiley Periodicals, Inc.

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Assessment of the variability in the anatomical position and size of the subthalamic nucleus among patients with advanced Parkinson’s disease using magnetic resonance imaging

Abstract: It is now possible to directly evaluate STNs at 1.5 T with minimal image distortion, which reveals variation in STN position and dimensions in the range of nucleus size. This puts under question the rationale of use of standard STN coordinates during DBS surgery.

Cited by 67 publications

References 23 publications

Imaging for deep brain stimulation: The zona incerta at 7 Tesla

Imaging for deep brain stimulation: The zona incerta at 7 Tesla

Stimulation sites in the subthalamic nucleus projected onto a mean 3-D atlas of the thalamus and basal ganglia

A Novel Method for Constructing Histological Section Datasets of the Basal Ganglia in Digitized Human Brain

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