Assessment of the usefulness of skin phototype and skin color as the parameter of cutaneous narrow band UVB sensitivity in psoriasis patients

Youn, Jai Il; Park, Jeyoung; Jo, Seong Jin; Rim, Jong Hyun; Choe, Yong Beom

doi:10.1034/j.1600-0781.2003.00047.x

Cited by 27 publications

(28 citation statements)

References 13 publications

(21 reference statements)

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“…The measured L* value of the normal control skin showed a significant correlation to the MED, which is in agreement with the previous reports 4 .…”

Section: Discussionsupporting

confidence: 82%

“…The reflexibility value of the separated light is measured by a photodiode array detector and the values are integrated to form a reflexibility value curve. The errors of the level of erythema and the pigmentation of the skin, which are caused by the subjective determination of examiners, can be overcome by using the spectrophotometer 4 , and the spectrophotometer can be applied to assess the effectiveness of various therapies such as drug application, laser etc [11][12][13] .…”

Section: Discussionmentioning

confidence: 99%

“…The spectrophotometer primarily presents the color of materials as the L*a*b* color space parameter (L*a*b* values): brightness is presented as L*, chromacity that shows hue and saturation are presented as a* and b*, and it presents the color differences as delta E by combining these values. In recent years, it has been reported that L* is associated with constitutive skin color and so it is significantly correlated to the MED 4 , and a* is a value associated with erythema.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Study of the Gross Interpretation of Phototesting and Objective Measurement with Using a Spectrophotometer for Patients with Psoriasis and Vitiligo Treated with Narrow-band UVB

Choi

Kim

2009

Ann Dermatol

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Background: Determination of the minimal erythema dose (MED) is important for developing a phototherapy protocol and to diagnosis photosensitivity disorders. But obtaining a precise and reproducible MED is quite difficult because a phototest for erythema is based on subjective assessment. Objective: The objective of our study was to compare the gross interpretation of a phototest and the objective measurement using a spectrophotometer for determining the parameters of cutaneous narrow-band UVB (NBUVB) therapy. Methods: A total of 14 psoriasis and 10 vitiligo patients who receiving NBUVB phototherapy with skin types III and IV were selected for this study. To perform phototesting, ten sites on the skin of the back were vertically exposed to a series of 10 NBUVB doses among 14 doses between 340 and 1,400 mJ/cm 2 . We interpreted the gross findings of erythema and measured the L*a*b* values with using a spectrophotometer at each phototest spot and at the control skin. Also, we evaluate the relationship between the gross presentation and the spectrophotometric analysis by delta E for the assessment of the minimal perceptible erythema (MPE) and MED. Results: For all the subjects, the MEDs were measured in the 490∼1,000 mJ/cm 2 range. The average of the colorimetric values for the control skin were L*: 64.8, a*: 7.9 and b*: 19.8. Among them, the L* value and MED value were shown to be inversely correlated, and as the L* value was decreased, the MED was increased. For the MPE, the delta E, which was the color difference of the normal skin and the phototest area, was within the range of 1.5∼3.0 in 17 of the 21 patients, and 4 patients were within the range of 1.0∼1.5. For the MED, among the 21 patients, the delta E of 17 patients was within the range of 3.0∼6.0, and 4 patients were within the range of 6.0∼12.0. Conclusion: A spectrophotometer enables UV erythema to be assessed objectively and quantitatively, and this can compensate for the disadvantages of subjective gross interpretation when determining the MED. Delta E is a good novel and objective indicator for determining the MPE and MED. So, a spectrophotometer is a very useful instrument for developing a phototherapy protocol for psoriasis and other dermatoses and for making the diagnosis of photosensitivity disorders. (Ann Dermatol 21(2) 136∼141, 2009)

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“…The measured L* value of the normal control skin showed a significant correlation to the MED, which is in agreement with the previous reports 4 .…”

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Study of the Gross Interpretation of Phototesting and Objective Measurement with Using a Spectrophotometer for Patients with Psoriasis and Vitiligo Treated with Narrow-band UVB

Choi

Kim

2009

Ann Dermatol

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“…6 Options for the assessment of erythema: Some studies use the L* (darkness) value of the spectrophotometer rather than the a* (redness) value. 7,8 A likert-type visual rating scale for erythema can be also used instead of spectrophotometry.…”

Section: Discussionmentioning

confidence: 99%

Minimal Erythema Dose (MED) Testing

Heckman

Chandler

Kloss

et al. 2013

JoVE

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Ultraviolet radiation (UV) therapy is sometimes used as a treatment for various common skin conditions, including psoriasis, acne, and eczema. The dosage of UV light is prescribed according to an individual's skin sensitivity. Thus, to establish the proper dosage of UV light to administer to a patient, the patient is sometimes screened to determine a minimal erythema dose (MED), which is the amount of UV radiation that will produce minimal erythema (sunburn or redness caused by engorgement of capillaries) of an individual's skin within a few hours following exposure. This article describes how to conduct minimal erythema dose (MED) testing. There is currently no easy way to determine an appropriate UV dose for clinical or research purposes without conducting formal MED testing, requiring observation hours after testing, or informal trial and error testing with the risks of under-or over-dosing. However, some alternative methods are discussed. Video LinkThe video component of this article can be found at

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“…A previous study reported that AD was due to an increase in the IFN-γ to IL-4 ratio (Kevin, 1994). Also, mononuclear cells of AD patients produce more cytokines (such as IL-4, IL-5, and IL-13) compared to those of healthy individuals (Patrick, 1994;Yoon et al, 2003 ) …”

Section: Atopic Dermatitis (Ad) Is a Chronic Inflammatory Dermatitis mentioning

confidence: 99%

Anti-atopic Effects of the Silkworm Feces Extracts in the NC/Nga Mice

Ju¹,

Kim²,

Kim³

et al. 2013

International Journal of Industrial Entomology

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This study was evaluated the antiatopic activity of silkworm feces extracts in DNCBinduced NC/Nga atopy mice. It was found that each level of IgE and histamine in blood was significantly decreased in the silkworm feces extracts treatment groups, compared with the DNCB-induced atopy control group. When the silkworm feces extracts was applied to the atopy mice, it could be observed that its skin recovered to normal condition with the skin surface being clean and smooth without any tissue. The results suggest that the application of silkworm feces extracts effect on atopic model through a inhibition of histamine emissions with reducing the levels of blood IgE in NC/Nga atopy mice. Atopic dermatitis (AD) is a chronic inflammatory dermatitis that presents with itchiness and inflammation. When allergens(the causative factors of the allergy) enter the body, IgE is produced in B-cells (in the blood) and transported to mast cells in the skin. It then combines with basophils (a type of white blood cell), and histamine is formed and stored; upon repeated exposure to the same allergens, allergic symptoms occur (Harifin and Rajka, 1980;Horsmanheimo et al., 1994;Baugh and Bucala, 2001;Meyer, 2003). . A previous study reported that AD was due to an increase in the IFN-γ to IL-4 ratio (Kevin, 1994). Also, mononuclear cells of AD patients produce more cytokines (such as IL-4, IL-5, and IL-13) compared to those of healthy individuals (Patrick, 1994;Yoon et al., 2003 )

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Assessment of the usefulness of skin phototype and skin color as the parameter of cutaneous narrow band UVB sensitivity in psoriasis patients

Abstract: The MED value of NBUVB in our study is a basic data to set the phototherapy protocol. Our result showed that skin type and L* value might be useful for predicting the sensitivity to NBUVB irradiation.

Cited by 27 publications

References 13 publications

Comparative Study of the Gross Interpretation of Phototesting and Objective Measurement with Using a Spectrophotometer for Patients with Psoriasis and Vitiligo Treated with Narrow-band UVB

Comparative Study of the Gross Interpretation of Phototesting and Objective Measurement with Using a Spectrophotometer for Patients with Psoriasis and Vitiligo Treated with Narrow-band UVB

Minimal Erythema Dose (MED) Testing

Anti-atopic Effects of the Silkworm Feces Extracts in the NC/Nga Mice

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