Background: This study aims to investigate the relationship of Type D personality to glycated hemoglobin (HbA1c) and health-related quality of life (HRQOL) directly, and also indirectly via diabetes distress and social isolation in people with type 2 diabetes. Methods: Secondary data analysis of a cross-sectional survey was used. Data on 524 people with type 2 diabetes from outpatient clinics were obtained from June 2020 to February 2021. The hypotheses of this study were tested using the PROCESS macro with 10,000 bootstrapping iterations to estimate 95% con dence intervals (CIs) for indirect (mediating) effects.Results: Type D personality was present in 31.3% of the participants, and exerted a signi cant direct effect on HRQOL but not on HbA1c. Type D personality exerted a signi cant indirect effects on HbA1c via diabetes distress and social isolation (95% CI = 0.014 to 0.163 and 0.007 to 0.121, respectively), and on HRQOL via diabetes distress and social isolation (95% CI = -0.335 to -0.178 and -0.056 to -0.008, respectively). The indirect effects of Type D personality on HRQOL via diabetes distress had a greater magnitude than that via social isolation. Conclusion: It is necessary for health professionals to monitor people with type 2 diabetes to determine whether Type D personality is present. Those with Type D personality should be provided with interventions to reduce diabetes distress and alleviate social isolation in order to improve their glycemic control and HRQOL.