Assessment of the toxic effect exerted by fluorescent pseudomonads on embryos and larvae of the sea urchin Strongylocentrotus nudus

Беленева, И. А.; Shamshurina, E. V.; Елисейкина, М. Г.

doi:10.1016/j.ecoenv.2015.02.030

Cited by 10 publications

(1 citation statement)

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“…Their toxic influence is accompanied by disturbances of protein synthesis and disruptions to the cytoskeleton during zygote cleavage and larval development. 27 The most radical approaches to Pseudomonas aeruginosa infection are to perform surgical debridement and bone and soft tissue resections or amputation of the infected foot.…”

Section: Discussionmentioning

confidence: 99%

Benefits of Acidifying Agents in Local Therapy of Diabetic Foot Ulcers Infected by Pseudomonas sp: A Pilot Study

Fejfarová

Tibenská

Niklová

et al. 2019

The International Journal of Lower Extremity Wounds

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Infections caused by Pseudomonas sp are difficult to resolve by antibiotics (ATBs) and local therapy. The aim of our pilot study was to assess the effect of different local agents—particularly acidifying solutions—on the healing of diabetic foot ulcers (DFUs), eradication of pathogens, and economic costs related to DFU therapy. In this case study, we monitored 32 DFU patients infected by Pseudomonas species. Patients were divided into 2 groups according to the local therapy provided: group 1 (n = 15)—modern local treatment; group 2 (n = 17)—acidifying antiseptic solutions. The study groups differed only with regard to ATB usage prior to enrolment in the study ( P = .004), but did not differ with regard to age, diabetes control, peripheral arterial disease, or microcirculation status. During the follow-up period, DFUs healed in 20% of cases in group 1, but there were no cases of healing in group 2 (NS). The length of ATB therapy, the number of new osteomyelitis, lower limb amputations, and the changes of DFUs status/proportions did not differ significantly between study groups. Pseudomonas was eradicated in 67% of cases in group 1 and in 65% of cases in group 2. The local treatment given to group 2 patients was associated with lower costs ( P < .0001). Conclusion. Acidifying agents had the same effect as modern healing agents on wound healing, the number of amputations, and the eradication of Pseudomonas. Moreover, therapy performed using acidifying solutions proved in our pilot study markedly cheaper.

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Section: Discussionmentioning

confidence: 99%