Assessment of the size of acute myocardial infarction I: biochemical methods

Bruschke, A. V. G.; Laarse, Arnoud van der; Wall, Ernst E. van der

doi:10.3949/ccjm.57.6.547

Cited by 9 publications

(5 citation statements)

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“…Subsequently these levels were determined every day up to discharge, unless clinical events suggested repeat measurements. The cumulative release of CK in the first 48 hr was calculated as a measure of infarct size in each patient by an investigator blinded to the assigned treatment [12]. Other measures of infarct size were peak levels of CK and TnT in plasma.…”

Section: Methodsmentioning

confidence: 99%

In‐ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: Results from the Leiden MISSION! acute myocardial infarction treatment optimization program

Abolghasemi

Liem

Kley

et al. 2009

Cathet Cardio Intervent

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Section: Methodsmentioning

confidence: 99%

In‐ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: Results from the Leiden MISSION! acute myocardial infarction treatment optimization program

Abolghasemi

Liem

Kley

et al. 2009

Cathet Cardio Intervent

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“…Serum α-hydroxybutyrate dehydrogenase (α-HBDH) is an isoenzyme of lactate dehydrogenase (LDH), and its acts by catalyzing the oxidation of α-hydroxybutyrate to α-ketobutyric acid [1]. In the human body, α-HBDH is found in a variety of tissues, with the highest concentration in the cardiac tissue, followed by the red blood cells, white blood cells, and kidneys [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of serum α-HBDH levels in patients with lung cancer

Zhang¹,

Wang

Chen

2023

World J Surg Onc

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Background The purpose of our study is to investigate the expression level and prognostic value of serum α-hydroxybutyrate dehydrogenase (α-HBDH) in lung cancer (LC) patients. Method LC patients treated in the Department of Oncology, Shaanxi Provincial Cancer Hospital from January 2014 to December 2016 were included in this study, all of whom underwent serological detection of α-HBDH prior to admission, and were enrolled in follow-up 5-year survival. Comparing the differences between high group and normal groups based on α-HBDH and LDH expression via clinicopathological parameters and laboratory data. Univariate and multivariate regression and overall survival (OS) were analyzed to explore whether elevated α-HBDH was an independent risk factor for LC, compared to LDH. Results Multivariate regression analysis showed that age (P = 0.018), liver metastasis (P = 0.011), α-HBDH (P = 0.015), and neutrophil-to-lymphocyte ratio (NLR) (P = 0.031) were independent prognostic factors affecting OS in LC patients. The overall diagnostic efficacy of α-HBDH (AUC = 0.887) was higher than that of LDH (AUC = 0.709) in the ROC curve. The sensitivity was significantly higher of α-HBDH (sensitivity: 76.06%, specificity: 94.87%) compared with LDH (sensitivity: 49.30%, specificity: 94.87%). The median of OS was more significant in the high-α-HBDH group (6.4 months) than in the normal-α-HBDH group (12.7 months) (P = 0.023). The median of OS was significant in the high-LDH (> 245 U/L) group at 5.8 months and 12.0 months in the normal-LDH (≤ 245 U/L) group (P = 0.068). Conclusions Elevated expression of α-HBDH may indicate a poor prognosis of LC patients. It has a higher sensitivity than LDH and can be used as a potential early biomarker and an independent risk factor predicting the prognosis of LC survival.

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“…α-HBDH, which plays a role in catalyzing the oxidation of α-hydroxybutyrate to α-ketobutyric acid, is one of the enzymes that contributes to the formation of the myocardial enzyme spectrum and reflects hemolysis and heart injury when the level increases [ 13 , 14 ]. The increase in α-HBDH in serum was not only the result of myocardial injury, but also associated with the damage to the renal and hematologic systems, which reflected the abnormity of multiple systems and might be a predictive factor for adverse prognosis of patients with systemic disease, such as viral infection and malignant carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Serum α-hydroxybutyrate dehydrogenase as a biomarker for predicting survival outcomes in patients with UTUC after radical nephroureterectomy

Ye,

Zheng,

Chen

et al. 2024

BMC Urol

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Purpose We aimed to determine the prognostic value of α-hydroxybutyrate dehydrogenase (α-HBDH) in upper tract urothelial carcinoma (UTUC) patients after radical nephroureterectomy (RNU). Materials and methods We retrospectively enrolled the data of 544 UTUC patients at West China Hospital from May 2003 to June 2019. Cancer-specific survival (CSS) was the endpoint of interest. The optimal cutoff value of α-HBDH was identified by X-Tile program. After propensity score matching (PSM), we utilized Kaplan‒Meier curves to estimate survival and Cox proportional hazard model for risk assessment. A nomogram was built based on the results of multivariate analysis, and calibration curve, time-dependent receiver operating characteristic (ROC) curves and decision curve analysis were also performed to evaluate the predictive accuracy. Results Overall, 394 and 150 patients were divided into the α-HBDH-low group and α-HBDH -high group at the cutoff value of 158 U/L, respectively. After PSM, the two groups were well matched for all confounding factors. High α-HBDH was associated with inferior CSS (P = 0.006), and preoperative α-HBDH was an independent predictor for CSS (HR: 1.36; 95% CI:1.08, 1.80), especially in localized UTUC patients (HR: 2.04; 95% CI:1.11, 3.74). Furthermore, the nomogram based on α-HBDH achieved great predictive ability for CSS with areas under the curves of 0.800 and 0.778 for 3-year and 5-year CSS, respectively. Conclusion Serum α-HBDH was a novel and reliable biomarker for predicting survival outcomes in UTUC patients after RNU but should be further explored.

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Assessment of the size of acute myocardial infarction I: biochemical methods

Cited by 9 publications

References 0 publications

In‐ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: Results from the Leiden MISSION! acute myocardial infarction treatment optimization program

In‐ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: Results from the Leiden MISSION! acute myocardial infarction treatment optimization program

Prognostic value of serum α-HBDH levels in patients with lung cancer

Serum α-hydroxybutyrate dehydrogenase as a biomarker for predicting survival outcomes in patients with UTUC after radical nephroureterectomy

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