Assessment of the Single-Occlusion Technique for Measurements of Respiratory Mechanics and Respiratory Drive in Healthy Term Neonates Using a Commercially Available Computerized Pulmonary Function Testing System

Section: Resistance and Compliancesupporting

confidence: 90%

Section: Feasibilitymentioning

confidence: 99%

Assessment of respiratory mechanics with forced oscillations in healthy newborns

Hantos

Czövek

Gyurkovits

et al. 2014

“…Calculation of compliance and resistance, as well as work of breathing, is usually achieved using any of several traditional manual methods or computerized regression analysis algorithms employing some form of the above equation . Respiratory mechanics can also be measured passively by various occlusion or forced oscillation techniques …”

Section: Measurement Methods Of Pulmonary Mechanics Energetics and mentioning

confidence: 99%

Evaluation of bedside pulmonary function in the neonate: From the past to the future

Reiterer

Sivieri

Abbasi

2015

Self Cite

Pulmonary function testing and monitoring plays an important role in the respiratory management of neonates. A noninvasive and complete bedside evaluation of the respiratory status is especially useful in critically ill neonates to assess disease severity and resolution and the response to pharmacological interventions as well as to guide mechanical respiratory support. Besides traditional tools to assess pulmonary gas exchage such as arterial or transcutaenous blood gas analysis, pulse oximetry, and capnography, additional valuable information about global lung function is provided through measurement of pulmonary mechanics and volumes. This has now been aided by commercially available computerized pulmonary function testing systems, respiratory monitors, and modern ventilators with integrated pulmonary function readouts. In an attempt to apply easy-to-use pulmonary function testing methods which do not interfere with the infant́s airflow, other tools have been developed such as respiratory inductance plethysmography, and more recently, electromagnetic and optoelectronic plethysmography, electrical impedance tomography, and electrical impedance segmentography. These alternative technologies allow not only global, but also regional and dynamic evaluations of lung ventilation. Although these methods have proven their usefulness for research applications, they are not yet broadly used in a routine clinical setting. This review will give a historical and clinical overview of different bedside methods to assess and monitor pulmonary function and evaluate the potential clinical usefulness of such methods with an outlook into future directions in neonatal respiratory diagnostics.

“…Assessment of pressure developed at the airway opening 100 msec after transient airway occlusion (P 0.1 ) provides a quantitative measure of respiratory drive. [87][88][89] Maximal airway opening pressure after occlusion and maximal airway opening pressure after 100 msec were also reported to reflect respiratory drive. 90 The technique quantifies the reflex inspiratory drive to breathe in response to upper airway occlusion at end-expiration.…”

Section: Transient Airway Occlusionmentioning

confidence: 99%

Lung‐function tests in neonates and infants with chronic lung disease: Tidal breathing and respiratory control

Baldwin

Pillow

Stocks³

et al. 2006

This paper is the fourth in a series of reviews that will summarize available data and critically discuss the potential role of lung-function testing in infants with acute neonatal respiratory disorders and chronic lung disease of infancy. The current paper addresses information derived from tidal breathing measurements within the framework outlined in the introductory paper of this series, with particular reference to how these measurements inform on control of breathing. Infants with acute and chronic respiratory illness demonstrate differences in tidal breathing and its control that are of clinical consequence and can be measured objectively. The increased incidence of significant apnea in preterm infants and infants with chronic lung disease, together with the reportedly increased risk of sudden unexplained death within the latter group, suggests that control of breathing is affected by both maturation and disease. Clinical observations are supported by formal comparison of tidal breathing parameters and control of breathing indices in the research setting.