Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats

Evaluation of the liver protection and toxicity of Da-Huang-Zhe-Chong pill in rats

“…The general status of the rats, including mental status, weight change, food intake, etc, was first visually observed and recorded (Suresh et al, 2008;Wang et al, 2009 a,c).…”

Identification of the antidiarrhoeal components in official rhubarb using liquid chromatography–tandem mass spectrometry

“…The major bioactive components of rhubarb are phenolic compounds. Among them, sennosides (bianthrones) and anthraquinone glycosides are considered as the main purgative components, while free anthraquinones possess anti-inflammatory effects (Xiao et al, 1984), anticancer activity (Huang et al, 2007), nephric protection (Wang et al, 2009a), liver protection (Zhao et al, 2009) and antimicrobial activity (Wang et al, 2010). In addition, glucose gallates (Kashiwada, Nonaka, Nishioka, & Yamagishi, 1988), naphthalenes (Tsuboi, Minami, Nonaka, & Nishioka, 1977), and catechins (Kashiwada, Nonaka, & Nishioka, 1986) have been isolated from rhubarbs, and exhibit potential antioxidant and anticancer activities.…”

In vivo metabolism study of rhubarb decoction in rat using high-performance liquid chromatography with UV photodiode-array and mass-spectrometric detection: A strategy for systematic analysis of metabolites from traditional Chinese medicines in biological samples

“…Pharmacological studies indicate that rhubarb has various bioactivities, such as purgative [2,3], antiviral [4,5], antibacterial [6], anti-inflammatory [7,8], protecting effects in rat with chronic renal failure [9,10], anti-angiogenic [11], antioxidative [12,13], inhibiting epoxidase [14], immunomodulatory [15], protecting vascular endothelium and alveolar epithelium [16].…”