Assessment of the relationship between transepidermal water loss (TEWL) and severity of clinical signs (CADESI‐03) in atopic dogs

Abstract

The results indicate that it may be possible to use measurement of TEWL to assess the severity of skin lesions, but a positive correlation was found in only five of 10 body regions examined.

The influence of non-specific anti-pruritus treatment with cyclosporine A on transepidermal water loss (TEWL) in natural atopic dermatitis in dogs

“…The correlation between TEWL and CADESI was previously the object of study of Marsella R. (2012) and Zając et al (2014), who confirmed the existence of such a correlation in atopic dogs.…”

“…The studies have demonstrated that in atopic dogs the parameter takes higher values than in healthy dogs, and that the values are also higher on clinically affected skin. The studies published in 2012 by Marsella and in 2014 by Zając et al have additionally reported a positive correlation between this parameter and the severity of the clinical signs of the disease as assessed by the CADESI ( Marsella 2012, Zając et al 2014. Furthermore, studies have demonstrated that TEWL values decrease in remission during specific immunotherapy and non-specific anti-pruritus treatment (using cyclosporine) (Cornegliani et al 2012).…”

“…These methods, and especially the assessment of transepidermal water loss, are commonly used with human patients and have recently also been used more widely with animals. The most commonly applied method has been the assessment of TEWL, which was measured in healthy dogs, cats and horses (Shimada et al 2008, 2012 as well as in atopic dogs (Hightower et al 2010, Cornegliani et al 2012, Marrsella 2012, Zając et al 2014. The studies have demonstrated that in atopic dogs the parameter takes higher values than in healthy dogs, and that the values are also higher on clinically affected skin.…”

Influence of horse breed on transepidermal water loss

“…It has also been used to monitor the efficiency of locally applied medicines (Marsella et al 2006, Shimada et al 2009, Hightower et al 2010, Cornegliani et al 2011, Eui-Hwa Nam et al 2012. Correlations have been reported between TEWL values and clinical condition of the skin in some of body regions examined (assessment performed with CADESI) (Marsella 2012, Zając 2014. Also, the effects of breed, age and body regions on the results obtained have been investigated (Young et al 2002, Bourdeau et al 2004, Oh and Oh 2009a,b, Hightower et al 2010, Szczepanik et al 2011, 2012.…”

“…The most commonly applied parameter has been TEWL, and most of the studies have concentrated on dogs. This parameter has been assessed in both clinically healthy animals and animals with atopic dermatitis (Beco and Fontaine 2000, Zając et al 2014, 2015a. It has also been used to monitor the efficiency of locally applied medicines (Marsella et al 2006, Shimada et al 2009, Hightower et al 2010, Cornegliani et al 2011, Eui-Hwa Nam et al 2012.…”