Assessment of the relationship between non‐alcoholic fatty liver disease and diabetic complications

Yan, Long; Mu, Biao; Guan, Yue; Liu, Xinyu; Zhao, Nan; Pan, Da; Wang, Shaozhen

doi:10.1111/jdi.12518

Cited by 39 publications

(31 citation statements)

References 37 publications

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“…Our data clearly show a marked reduction in prevalence of retinopathy associated with the presence of FL never before described for Caucasians and Africans. This under-prevalence was occasionaly noted in Asians, whereas an overprevalence of retinopathy was reported by Targher et al in Italians [21] [22] [23] [24]. Our data are the first to document an FL-related ophthalmoprotection in Caucasians and Africans, prevailing beyond the retinal vessels since ocular hypertonia and cataracts were also reduced.…”

Section: Discussionsupporting

confidence: 64%

Fatty Liver Linked to Reduced Frequency of Ocular Complications in T2DM

Gninkoun¹,

Ahn²,

Amoussou-Guenou³

et al. 2020

JDM

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Purpose: Non-alcoholic fatty liver (NAFL) is comorbid to obesity, metabolic syndrome and type 2 diabetes mellitus (T2DM). It is unclear whether NAFLD constitutes a direct risk factor for macrovascular disease in T2DM. This study aimed at revisiting the cardiometabolic traits linked to NADL and micro-/ macrovascular complications in a biethnic Caucasian and African cohort. Methods: Cross-sectional analysis of 568 of T2DM patients (515 Caucasians; 53 Africans) in whom the presence of NAFL was identified by ultrasonography and the cardiometabolic phenotype was exhaustively characterized, including carbohydrate homeostasis, comprehensive lipidogram including Lp(a), cumulative exposure to hyperglycemia, and prevalent micro/macrovascular complications. Results: FL was present in 73% of Caucasians and 36% of Africans (p < 0.0001). FL+ were more obese, more atherogenic dyslipidemic (Caucasians) and had lower lipoprotein(a) (Africans). All-cause macroangiopathy, ischemic heart disease or stroke did not significantly differ between FL+ and FL− in both groups. A marked reduction in diabetic retinopathy (DR), ocular hypertonia and cataracts were found in FL+ of the two ethnicities. In FL+ Caucasians, relative risk of DR was −38%, cataracts −35%, and ocular hypertonia −42%. In FL+ Africans, risk of overall microangiopathy was −66% and that of DR −86%. Conclusions: An inverse association was observed between NAFL and the presence of diabetic retinopathy, cataract and ocular hypertonia. The ophthalmoprotection conferred by liver steatosis was found in Caucasians

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Section: Discussionsupporting

confidence: 64%

Fatty Liver Linked to Reduced Frequency of Ocular Complications in T2DM

Gninkoun¹,

Ahn²,

Amoussou-Guenou³

et al. 2020

JDM

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“…In the Atherosclerosis Risk in Communities (ARIC) study, which was based in the United States, no relationship between metabolic syndrome and retinopathy was observed in individuals without diabetes[25]. In recent study, Yan et al[26] reported that NAFLD combined with type 2 diabetes group had a lower prevalence of diabetic retinopathy than type 2 diabetes-alone group. However, Yang et al[27] noted that NAFLD is a predisposing factor for retinal artery lesions, but individuals with diabetes may have been included in this previous study and confounded the result.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Nonalcoholic Fatty Liver Disease and Retinopathy in NHANES III

Lin

Chen

et al. 2016

PLoS ONE

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BackgroundNonalcoholic fatty liver disease (NAFLD), an emerging multisystem disease, has the similar pathogenesis with diabetes and is prevalent in diabetes. This study investigated whether NAFLD is associated with retinopathy in individuals with diabetes and without diabetes.MethodsThe association between NAFLD and retinopathy was investigated in 5963 participants aged 40 years and older who participated in the NHANES III, a nationally representative, population-based and cross-sectional study. NAFLD was detected via ultrasonography, and fundus photographs were obtained to grade retinopathy patterns. We performed multivariate logistic regression analysis to investigate the relationship between the presence of retinopathy and NAFLD and diabetes.ResultsAfter adjusting for multiple covariates, NAFLD population had no evidence of retinopathy increase in population without diabetes (odds ratio [OR]: 0.77; 95% confidence interval [CI]: 0.48 to 1.26). In addition, NAFLD in individuals with diabetes was not significantly associated with retinopathy (OR: 0.77; 95% CI: 0.47 to 1.26), independent of age, gender, ethnicity, waist circumference, serum high-density lipoprotein (HDL) cholesterol, serum triglycerides, systolic blood pressure, and glycated hemoglobin.ConclusionsIn the US general population, NAFLD is not a precipitating factor of retinopathy in population with or without diabetes.

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“…Several observational studies, although not all [154,155] , have documented a significant association between NAFLD and prevalent distal symmetric polyneuropathy in patients with T2DM [22,39,71] . This association persisted even after adjustment for many cardiometabolic risk factors and other potential confounders.…”

Section: Association Between Nafld and Distal Symmetric Polyneuropathmentioning

confidence: 99%

Prevalence and incidence of intra- and extrahepatic complications of NAFLD in patients with type 2 diabetes mellitus

Mantovani¹,

Beatrice²,

Stupia³

et al. 2020

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Nonalcoholic fatty liver disease (NAFLD) is linked to abdominal obesity, insulin resistance and type 2 diabetes mellitus (T2DM). The association of NAFLD with T2DM is bidirectional. In fact, evidence suggests that abdominal obesity, T2DM and metabolic syndrome play a part in the development and progression of NAFLD. Alternatively, NAFLD is associated with an increased risk of having T2DM and metabolic syndrome. According to this background, it is unsurprising that patients with T2DM patients also have a higher prevalence of NAFLD than those with no T2DM, as well as an increased risk of developing liver-related and extrahepatic complications, mainly cardiovascular and renal diseases. Seeing the relationship of NAFLD with insulin resistance, obesity and T2DM, recent consensus proposes a change in nomenclature from NAFLD to metabolic associated fatty liver disease. In this review, we will discuss the prevalence and incidence of NAFLD (as detected by imaging techniques or liver biopsy) in patients with type T2DM with particular regard to hepatic and extrahepatic complications.

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Assessment of the relationship between non‐alcoholic fatty liver disease and diabetic complications

Cited by 39 publications

References 37 publications

Fatty Liver Linked to Reduced Frequency of Ocular Complications in T2DM

Fatty Liver Linked to Reduced Frequency of Ocular Complications in T2DM

The Relationship between Nonalcoholic Fatty Liver Disease and Retinopathy in NHANES III

Prevalence and incidence of intra- and extrahepatic complications of NAFLD in patients with type 2 diabetes mellitus

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