Assessment of the Relation between Biomarkers for Smoking and Biomarkers for Acrylamide Exposure in Humans

Abstract

Smoking is an important source of acrylamide exposure in the general population. We assessed the relationship between hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA) as biomarkers of acrylamide exposure and plasma cotinine (PC) as biomarkers of tobacco smoke exposure in 94 men and 67 women. The median (5th-95th percentile) biomarker concentrations (pmol/g Hb) in the group of individuals with PC concentrations of V10 ng/mL were 51 (29-155) and 34 (16-117) for HbAA and HbGA, respectively. They were significantly lower than those in the group of individuals with PC concentrations of >10 ng/mL [194 (87-403) and 107 (41-215) for HbAA and HbGA, respectively]. In individuals with PC concentrations of <1 ng/mL, HbAA and HbGA were similar to those observed in the group with PC values of V10 ng/mL. The intersubject variability was profoundly smaller in the group with PC values of V10 ng/mL compared with the group with PC values of >10 ng/mL. Although HbAA and HbGA could be categorized into distinguishable groups using PC concentration ranges commonly used to categorize presumed smokers and nonsmokers, no significant relationship was observed between these two biomarkers and PC within each group. The different exposure periods reflected by these biomarkers and the resulting different susceptibility to short-term variations in exposure patterns may in part explain these observations. The findings suggest that tobacco smoke exposure in individuals with PC values of <1 ng/mL has only a minimal effect

Self-reported symptoms and neuropsychological function among tunnel workers previously exposed to acrylamide and N-methylolacryl­amide

“…Increased tremor has been found among smokers or snuffers compared to non-smokers/non-snuffers (29). Cigarette smoking is also a source of acrylamide exposure (30)(31)(32), although acrylamide neurotoxicity due to smoking alone is not clinically relevant (32). The proportion of current smokers was comparable in the two groups.…”

Dietary Acrylamide Intake and Prostate Cancer Risk in a Prospective Cohort of Swedish Men

“…Because smoking is an important source of acrylamide exposure (21,22), we conducted subgroup analyses for never smokers. All P values presented are two-sided and P < 0.05 was considered statistically significant.…”

KINETICS OF FORMATION OF (±)-Anti-7, 8-Dihydroxy-9α,10α -EPOXY-7, 8, 9, 10-Tetrahydrobenzo[a]pyrene ADDUCTS WITH MOUSE AND HUMAN HEMOGLOBIN

“…Subsequentlly, a number of studies by several investigators have demonstrated that carcinogenic compounds, especially those present in cigarette smoke (e.g., the tobacco-specific nitrosamines and 4-aminobiphenyl), bind covalently to hemoglobin (110)(111)(112)(113)(114). Hemoglobin presents itself as an ideal target for the interaction of various xenobiotics.…”