Assessment of the QT interval in right bundle branch block

Rabkin, Simon W.

doi:10.1080/00015385.2022.2066778

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…It is also important to stress that calculating the QT interval can be problematic, and if and when QT corrections are needed. Overestimation of the QT interval can occur when using conventional measurements in some patients (Fredholm et al , 2021; Rabkin, 2022). For patients with ventricular arrhythmias, there are specific guidelines to manage care and prevent SCD (Zeppenfeld et al , 2022).…”

Section: Discussionmentioning

confidence: 99%

Navigating the pharmacologic complexities of QTc prolongation: assessing the cumulative burden in individuals with serious mental illness

Demler

O’Donnell

2023

International Clinical Psychopharmacology

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The scientific progress made in the pharmacologic management of serious mental illness (SMI) has been significant. However, the benefits of medication management must continually be weighed against the risks of adverse effects of the agents prescribed. While many medications pose increased danger of QTc prolongation, which may result in malignant arrhythmia and sudden cardiac death, the combination of medications contributing QTc risk can result in an impact of unpredictable pharmacodynamic magnitude. Pharmacists play a key role in communicating QTc risks to prescribers, however little if any clinical guidance informs clinicians of specific actions to take when initiating or continuing a clinically necessary combination that poses risk. This study is a cross-sectional view of Med Safety Scan (MSS) QT prolongation risk scores, generated from the ranking tool available from the CredibleMeds website, intended to provide greater understanding of overall risk of QT burden to assist in the prescribing of medications to patients with SMI in a psychiatric hospital.

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Section: Discussionmentioning

confidence: 99%

Navigating the pharmacologic complexities of QTc prolongation: assessing the cumulative burden in individuals with serious mental illness

Demler

O’Donnell

2023

International Clinical Psychopharmacology

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Section: Introductionmentioning

confidence: 99%

“…Cardiac repolarization is traditionally assessed on the surface electrocardiogram (ECG) by measuring the QT interval, recognizing that this interval encompasses the duration of the QRS complex. 16 , 17 The QT duration or the QT interval on a 12 lead ECG is a risk factor for cardiac mortality, especially sudden cardiac death. 18 , 19 A meta‐analysis of population studies found a consistent association between prolonged QT interval and increased risk of total, cardiovascular, coronary, and sudden cardiac death.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Alzheimer dementia and QT interval: A meta‐analysis

Rabkin

2024

Aging Medicine

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While the link between aging and mortality from dementia is widely appreciated, the mechanism is not clear. The objective of this study was to determine whether there is a direct relationship between Alzheimer dementia (AD) and the QT interval, because the latter has been related to cardiac mortality. A systematic review and meta‐analysis were conducted after a Medline and EMBASE search using terms “Alzheimer disease or Dementia AND QT interval, QT dispersion or cardiac repolarization.” Four studies with control groups were identified. There were significant differences in QT interval between individuals with AD vs individuals without dementia (controls) (odds ratio (OR)1.665 [random effects model] and 1.879 [fixed effect model]) (p < 0.001). There were significant differences in QT interval between individuals with AD vs individuals with mild cognitive impairment (MCI) (OR 1.760 [random effects] and 1.810 [fixed effect]) (p < 0.001). A significant (p <0.001) correlation exists between the QTc and the Mini‐Mental State Exam (MMSE), a test of cognitive function. Two studies examined QT variability (the difference between the longest and shortest QT interval on a 12 lead ECG); the OR for QT variability AD vs MCI was 3.858 [random effects model] and 3.712 [fixed effects model] (p < 0.001). When compared to the control group, the OR for QT dispersion in AD was 6.358 [random effects model] or 5.143 ( P< 0.001) [fixed effects model]. A qualitative analysis of the data raised questions about paucity of data defining the nature of the control groups, the pathophysiologic mechanism, and the uniform use of a poor QT heart rate correction factor. The longer QT in AD, greater QT variability in AD, and the direct relationship between QT interval and AD severity supports a brain–heart connection in AD that might be fundamental to aging‐induced AD and mortality. Issues with defining the control group, limited number of studies, conflicting data in population studies, and the lack of a strong electrophysiological basis underscore the need for additional research in this field.

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Focus on cardiac rhythm disorders

Lancellotti,

Piette

2023

Acta Cardiologica

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Assessment of the QT interval in right bundle branch block

Cited by 3 publications

References 25 publications

Navigating the pharmacologic complexities of QTc prolongation: assessing the cumulative burden in individuals with serious mental illness

Navigating the pharmacologic complexities of QTc prolongation: assessing the cumulative burden in individuals with serious mental illness

Relationship between Alzheimer dementia and QT interval: A meta‐analysis

Focus on cardiac rhythm disorders

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