Assessment of the Procoagulant Activity of Microparticles and the Protein Z System in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery

Słomka, Artur; Piekuś, Aleksandra; Kowalewski, Mariusz; Pawliszak, Wojciech; Anisimowicz, Lech; Żekanowska, Ewa

doi:10.1177/0003319717706616

Cited by 14 publications

(7 citation statements)

References 49 publications

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“…Over the past few decades, the mechanisms of acute vascular events of smokers have been well studied, including induction of a hypercoagulable state, increased myocardial work, carbon monoxide-mediated reduction in the oxygen-carrying capacity of the blood, induction of endothelial dysfunction, coronary vasoconstriction, and catecholamine release. [4,16] In the present study, no positive association between smoking and POAF was observed, and smoking may have a protective effect on POAF. With a growing number of related studies, this phenomenon may be explained by that smokers have higher baseline levels of sympathetic activity and higher adrenergic tolerance.…”

Section: Discussioncontrasting

confidence: 73%

Association of smoking with postoperative atrial fibrillation in patients with cardiac surgery

Wan

Liu

2021

Medicine

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Background: Cigarette smoking is an important modifiable risk factor for incident atrial fibrillation. However, the impact of smoking on postoperative atrial fibrillation in patients undergoing cardiac surgery remains controversial. We performed this meta-analysis to explore the association of smoking with postoperative atrial fibrillation in patients with cardiac surgery. Methods: We systematically searched 2 computer-based databases (PubMed and EMBASE) up to July 2019 for all relevant studies. A random-effects model was selected to pool the odds ratios (ORs) and 95% confidence intervals (CIs). In this meta-analysis, the protocol and reporting of the results were based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement. Results: A total of 36 studies were included in this meta-analysis. Overall, smoking was not associated with an increased risk of postoperative atrial fibrillation in patients undergoing cardiac surgery (odds ratio [OR] = 0.89; 95% confidence interval [CI] 0.79–1.02). The corresponding results were stable in the subgroup analyses. Specifically, smoking was not associated with an increased risk of postoperative atrial fibrillation regardless of the type of cardiac surgery: coronary artery bypass grafting (OR = 0.91; 95% CI 0.77–1.07), valve surgery (OR = 0.15; 95% CI 0.01–1.56), and coronary artery bypass grafting+valve surgery (OR = 0.91; 95% CI 0.70–1.18). Conclusions: Based on currently published studies, smoking was not associated with an increased risk of postoperative atrial fibrillation in patients undergoing cardiac surgery.

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Section: Discussioncontrasting

confidence: 73%

Association of smoking with postoperative atrial fibrillation in patients with cardiac surgery

Wan

Liu

2021

Medicine

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“…One of the most widely used analytical methods for quantifying MVs levels and markers is flow cytometry (279). There are many different analytical methods used in MVs studies, such as electron microscopy (280), nanoparticle tracking analysis (280), western blot (280), dynamic light scattering (281), and enzyme-linked immunosorbent assay (282), however none of them is currently used in routine diagnostics. The vast majority of methods require special preparation of biological material samples and specialized equipment (283).…”

Section: Resultsmentioning

confidence: 99%

Large Extracellular Vesicles: Have We Found the Holy Grail of Inflammation?

et al. 2018

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The terms microparticles (MPs) and microvesicles (MVs) refer to large extracellular vesicles (EVs) generated from a broad spectrum of cells upon its activation or death by apoptosis. The unique surface antigens of MPs/MVs allow for the identification of their cellular origin as well as its functional characterization. Two basic aspects of MP/MV functions in physiology and pathological conditions are widely considered. Firstly, it has become evident that large EVs have strong procoagulant properties. Secondly, experimental and clinical studies have shown that MPs/MVs play a crucial role in the pathophysiology of inflammation-associated disorders. A cardinal feature of these disorders is an enhanced generation of platelets-, endothelial-, and leukocyte-derived EVs. Nevertheless, anti-inflammatory effects of miscellaneous EV types have also been described, which provided important new insights into the large EV-inflammation axis. Advances in understanding the biology of MPs/MVs have led to the preparation of this review article aimed at discussing the association between large EVs and inflammation, depending on their cellular origin.

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“…Furthermore, several studies have found that blood microparticle levels are elevated in individuals with CAD [4,5]. Different molecules on the surface of the microparticles mediate procoagulant properties that may lead to an acute coronary event [6].…”

Section: Introductionmentioning

confidence: 99%

Potential Beneficial Effects of Vitamin D in Coronary Artery Disease

et al. 2019

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Vitamin D plays a pivotal role in bone homeostasis and calcium metabolism. However, recent research has indicated additional beneficial effects of vitamin D on the cardiovascular system. This review aims to elucidate if vitamin D can be used as an add-on treatment in coronary artery disease (CAD). Large-scale epidemiological studies have found a significant inverse association between serum 25(OH)-vitamin D levels and the prevalence of essential hypertension. Likewise, epidemiological data have suggested plasma levels of vitamin D to be inversely correlated to cardiac injury after acute myocardial infarction (MI). Remarkably, in vitro trials have showed that vitamin D can actively suppress the intracellular NF-κB pathway to decrease CAD progression. This is suggested as a mechanistic link to explain how vitamin D may decrease vascular inflammation and atherosclerosis. A review of randomized controlled trials with vitamin D supplementation showed ambiguous results. This may partly be explained by heterogeneous study groups. It is suggested that subgroups of diabetic patients may benefit more from vitamin D supplementation. Moreover, some studies have indicated that calcitriol rather than cholecalciferol exerts more potent beneficial effects on atherosclerosis and CAD. Therefore, further studies are required to clarify these assumptions.

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Assessment of the Procoagulant Activity of Microparticles and the Protein Z System in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery

Cited by 14 publications

References 49 publications

Association of smoking with postoperative atrial fibrillation in patients with cardiac surgery

Association of smoking with postoperative atrial fibrillation in patients with cardiac surgery

Large Extracellular Vesicles: Have We Found the Holy Grail of Inflammation?

Potential Beneficial Effects of Vitamin D in Coronary Artery Disease

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