Assessment of the posterior segment of the cat eye by optical coherence tomography (OCT)

Gekeler, Florian; Gmeiner, Helmut; Völker, Michael; Sachs, Helmut; Messias, André; Eule, Corinna; Bartz‐Schmidt, Karl Ulrich; Zrenner, Eberhart; Shinoda, Kei

doi:10.1111/j.1463-5224.2007.00532.x

Cited by 32 publications

(45 citation statements)

References 16 publications

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“…First, the rabbit is certainly not the ideal animal in terms of retinal anatomy since its retina is parvangiotic, which makes it prone to more severe retinal degeneration than animals (such as humans) with holoangiotic retinas, where at least the inner retina is nourished by proprietary retinal vessels and should remain intact even in the presence of a subretinal implant (e.g., Gekeler et al 31,32 ). Second, the number of animals in our study was very small, and each animal was treated differently, which does inhibit statistical analysis.…”

Section: Discussionmentioning

confidence: 98%

Repeated transchoroidal implantation and explantation of compound subretinal prostheses: An exploratory study in rabbits

Gekeler

Kobuch²,

Blatsios

et al. 2010

Jpn J Ophthalmol

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Section: Discussionmentioning

confidence: 98%

Repeated transchoroidal implantation and explantation of compound subretinal prostheses: An exploratory study in rabbits

Gekeler

Kobuch²,

Blatsios

et al. 2010

Jpn J Ophthalmol

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“…Assim, a OCT tem sido aplicada com êxito para detectar alterações estruturais na retina em humanos, tais como mensuração da camada de fibras nervosas para monitorização em pacientes com glaucoma e mensuração da camada de fotorreceptores na retinose pigmentária (Gekeler et al 2007); esta caracterizada por alteração genética que afeta a camada de fotorreceptores e o EPR. O diagnós-tico é baseado nos achados fundoscópicos e na avaliação do ERG (Witkin et al 2006).…”

Section: Discussionunclassified

Aspectos da tomografia de coerência óptica em cães com retinopatia

2015

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A tomografia de coerência óptica (OCT) é um exame não invasivo e de não contato que permite avaliar a retina e o nervo óptico. As imagens da OCT fornecem informações da constituição da retina e sua integridade estrutural in vivo, gerando imagens de alta resolução, que se assemelham à microscopia óptica. Objetivou-se descrever a técnica de tomografia de coerência óptica (OCT) e sua utilização em cães. Foi possível diferenciar claramente as camadas retinianas de cães hígidos e compará-las com as de cães portadores de atrofia progressiva de retina, que apresentaram perda da estratificação e diminuição significativa das camadas. No descolamento de retina (DR) foi possível observar a separação entre a retina neurossensorial e o epitélio pigmentário da retina (EPR), além da presença de exsudatos intrarretinianos. Assim, a OCT mostrou-se eficaz no diagnóstico de retinopatias.

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“…The area centralis showed the least thickness, as expected. Intermediate values are found in the peripheral retina [93] .…”

Section: Catsmentioning

confidence: 98%

“…Studies of the histogenesis of the retina of the cat indicate that the process of retinal maturation is centered on the area centralis, which thus seems to be an organizing focus in the ontogeny as well as the adult function of the visual system [92] . In 2007, Gekeler et al [93] assessed the feasibility of optical coherence tomography (OCT) for examining the cat ocular fundus, to provide normative data on retinal thickness in different fundus regions. As was to be expected, retinal thickness varies across different regions of the cat's posterior pole.…”

Section: Catsmentioning

confidence: 99%

Retinal and Ocular Toxicity in Ocular Application of Drugs and Chemicals – Part I: Animal Models and Toxicity Assays

et al. 2010

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Aims: Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed. Methods: An extensive search of the literature was performed to review various aspects of the methods of investigation of drug toxicity. The different types of animal species, as well as single animal models available for the evaluation of safety and efficacy of retinal pharmacotherapy, were identified. In addition, a large variety of reported laboratory techniques were critically examined. Results: In vitro studies are the first-line experiments for the development of a new drug for retinal diseases, using retinal pigment epithelial cells and other cell lines. The next step involves in vivo animal studies where nonhuman primates are considered the gold standard. However, cost and legal issues make their use difficult. Mice and rats provide genetically controlled models for investigations. Pigs, dogs and cats represent good large-size animal models, while rabbits are one of the most used species for retinal toxicity evaluations. Various laboratory methods were identified, including light microscopy, electron microscopy, electroretinography and new emerging methods, such as optical coherence tomography and scanning laser ophthalmoscopy for experimental purposes. Conclusions: A great number of animal species and models are available that simulate retinal diseases and provide experimental data for further human use. Work with animal models should include properly designed toxicity assays to obtain reliable results for safety and efficacy.

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Assessment of the posterior segment of the cat eye by optical coherence tomography (OCT)

Cited by 32 publications

References 16 publications

Repeated transchoroidal implantation and explantation of compound subretinal prostheses: An exploratory study in rabbits

Repeated transchoroidal implantation and explantation of compound subretinal prostheses: An exploratory study in rabbits

Aspectos da tomografia de coerência óptica em cães com retinopatia

Retinal and Ocular Toxicity in Ocular Application of Drugs and Chemicals – Part I: Animal Models and Toxicity Assays

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