Assessment of the photoprotective potential and toxicity of Antarctic red macroalgae extracts from Curdiea racovitzae and Iridaea cordata for cosmetic use

Rangel, Karen Cristina; Villela, Leonardo Zambotti; Pereira, Karina de Castro; Colepicolo, Pio; Debonsi, Hosana Maria; Gaspar, Lorena Rigo

doi:10.1016/j.algal.2020.101984

Cited by 31 publications

(30 citation statements)

References 66 publications

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“…The critical wavelength ( λ C ) of each 1 – 3 was calculated, which is the wavelength at which the integrated area under the curve in the UV absorption spectrum starting from 290 nm is equal to 90% of the total area integrated from wavelength 290 – 400 nm. The λ C of 1 – 3 was each above 370 nm, meaning that these can be regarded as broad spectrum sunscreen molecules 8 . These are candidates for further development due to this property, the anti-inflammatory activity that has been demonstrated by the inhibition of NO production without cytotoxicity in vitro , and their structural differences from marketed products.…”

Section: Resultsmentioning

confidence: 99%

“…UV radiation also induces the release of pro-inflammatory cytokines such as COX-2, prostaglandin E 2 , interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and actively contribute to inflammation and sunburn 6 , 7 . There are commercial and often used natural products such as extracts of Polypodium leucotomos (Polypodiaceae) and micosporine-like amino acids that are considered to be safe and effective sunscreen ingredients since they reduce the generation and release of reactive oxygen species including NO 7 , 8 . Previous research for anti-inflammatory activity from marine fungal natural products has revealed many bioactive secondary metabolites, including those that exhibit their anti-inflammatory activity through inhibition of kinase pathways 9 .…”

Section: Introductionmentioning

confidence: 99%

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Targeted Isolation of Two New Anti-inflammatory and UV-A Protective Dipyrroloquinones from the Sponge-associated Fungus Aspergillus tamarii MCCF102

Niveditha

Leão

et al. 2022

Planta Med

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In following up on observed in vitro anti-inflammatory activity of the organic extract of the marine sponge-derived fungus Aspergillus tamarii MCCF102, two new dipyrrolobenzoquinones, terreusinone B and C (1 and 2), were discovered along with the known analogue, terreusinone (3). The structures of 1–3 were determined by spectroscopic and spectrometric analyses, along with chemical inter-conversion. In vitro testing on lipopolysaccharide (LPS) stimulated RAW 264.7 murine macrophage cells revealed that 1–3 exhibit anti-inflammatory activity by inhibiting nitric oxide production in a dose-dependent manner (IC50 < 1 μM) without any cytotoxicity observed at the same concentrations. Due to this and the UV-A absorptive properties imparted by the highly conjugated structures of these molecules, the potential for using <b>1</b>–<b>3</b> or related analogues as natural sunscreen components is suggested. Gene sequencing and informatics biosynthetic gene cluster comparisons were insufficient to confidently elucidate the biosynthetic origins of these compounds, possibly suggesting the occurrence of a gene cluster not detected in the initial sequencing or a non-canonical pathway that should be further investigated.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Targeted Isolation of Two New Anti-inflammatory and UV-A Protective Dipyrroloquinones from the Sponge-associated Fungus Aspergillus tamarii MCCF102

Niveditha

Leão

et al. 2022

Planta Med

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“…There are more than 30 MAAs produced by algae [ 117 ] and cyanobacteria [ 118 ], but the most reported for their protective potential against UVR are palythine (41) [ 119 ], asterina-330 (42) [ 119 , 120 ], shinorine (43) [ 118 , 119 ], and porphyra-334 (45) [ 118 ]. Rangel et al (2020) studied red macroalgae extracts from Curdiea racovitzae and Iridaea cordata , identifying, as major constituents, three MAAs, palythine (41), asterina-330 (42), and shinorine (43), which showed antioxidant, antiaging, and photoprotective effect in HaCaT keratinocytes, being demonstrated as non-cytotoxic and non-photounstable [ 119 ]. These MAAs were also found in an ethanolic extract of brown macroalgae Sargassum cristafolium , namely, palythine (41) [ 120 ].…”

Section: Prospectsmentioning

confidence: 99%

UV Filters: Challenges and Prospects

et al. 2022

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The use of sunscreens is an established and recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union, which ought to follow the requirements of the regulation 1223/2009 to ensure their efficacy and safety for humans. Nevertheless, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Particularly, the negative impact in marine organisms has recently raised concern on the scientific community. Therefore, it is important to develop new UV filters with improved safety profile and photostability. Over the last two decades, nearly 200 new compounds have revealed promising photoprotection properties. The explored compounds were obtained through different approaches, including exploration of natural sources, synthetic pathways, and nanotechnology. Almost 50 natural products and around 140 synthetic derivatives, such as benzimidazoles, benzotriazoles, hydroxycinnamic acids, xanthones, triazines, among others, have been studied aiming the discovery of novel, effective, and safer future photoprotective agents. Herein, we provide the reader with an overview about UV filters’ challenges and prospects, offering a forward-looking to the next-generation of UV filters.

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“…Recently, the anti-photoaging properties of two Antarctic red seaweeds, Curdiea racovitzae and Iridaea cordata , have been described [ 27 ]. Both red seaweeds extract contains high concentrations of MAAs (palythine, asterina-330, and shinorine).…”

Section: Seaweeds Extracts As Potential Anti-photoaging Agentsmentioning

confidence: 99%

Anti-Photoaging and Potential Skin Health Benefits of Seaweeds

2021

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The skin health benefits of seaweeds have been known since time immemorial. They are known as potential renewable sources of bioactive metabolites that have unique structural and functional features compared to their terrestrial counterparts. In addition, to the consciousness of green, eco-friendly, and natural skincare and cosmetics products, their extracts and bioactive compounds such as fucoidan, laminarin, carrageenan, fucoxanthin, and mycosporine like amino acids (MAAs) have proven useful in the skincare and cosmetic industries. These bioactive compounds have shown potential anti-photoaging properties. Furthermore, some of these bioactive compounds have been clinically tested and currently available in the market. In this contribution, the recent studies on anti-photoaging properties of extracts and bioactive compounds derived from seaweeds were described and discussed.

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Assessment of the photoprotective potential and toxicity of Antarctic red macroalgae extracts from Curdiea racovitzae and Iridaea cordata for cosmetic use

Cited by 31 publications

References 66 publications

Targeted Isolation of Two New Anti-inflammatory and UV-A Protective Dipyrroloquinones from the Sponge-associated Fungus Aspergillus tamarii MCCF102

Targeted Isolation of Two New Anti-inflammatory and UV-A Protective Dipyrroloquinones from the Sponge-associated Fungus Aspergillus tamarii MCCF102

UV Filters: Challenges and Prospects

Anti-Photoaging and Potential Skin Health Benefits of Seaweeds

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