Assessment of the ovarian volume, number and volume of follicles and ovarian vascularity by three-dimensional ultrasonography and power Doppler angiography on the HCG day to predict the outcome in IVF/ICSI cycles

Mercé, Luis T.; Bau, Santiago; Barco, María J.; Troyano, J. M.; Sotos, Florencia; Villa, A.

doi:10.1093/humrep/dei471

Cited by 41 publications

(35 citation statements)

References 31 publications

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“…Several reports have shown that this technique may be very useful in the detection of congenital uterine abnormalities, 12 assessment of uterine cavity disease, 13 and ovarian and endometrial volume estimation. 14,15 The differential diagnosis of adnexal masses still represents a challenge despite the tremendous efforts that have been made to improve the sonographically based diagnosis. This diagnosis is based on 2D sonography.…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Sonographic Morphologic Assessment of Adnexal Masses

Alcázar

García-Manero

Galván

2007

Journal of Ultrasound in Medicine

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Objective. The purpose of this study was to assess the reproducibility of 3-dimensional (3D) sonography for classifying adnexal masses. Methods. Eighty-two consecutive women with the diagnosis of an adnexal mass on 2-dimensional transvaginal sonography were reevaluated by 3D sonography, and 3D volume data from each mass were stored. Two different examiners (6 years and 1 year of experience in 3D sonography, respectively) reviewed 3D sonograms 1 month after the last patient was recruited and then 1 week later again. Masses had to be classified as benign or malignant. Criteria suggestive of malignancy were the presence of a thick wall, gross papillary projections, solid areas, and solid echogenicity. A definitive histologic diagnosis was obtained in every case. Intraobserver and interobserver agreement was estimated by calculating the Cohen κ index. Results. Twenty-seven (33%) tumors were malignant, and 55 (67%) were benign. Intraobserver agreement for both examiners was good (κ = 0.78 and 0.72, respectively). Interobserver agreement was also good (κ = 0.70). Conclusions. Three-dimensional sonography is a reproducible technique for morphologic assessment of adnexal masses. Key words: ovarian tumor; reproducibility; sonography; 3-dimensional sonography.Received March 27, 2007, Recently, 3-dimensional (3D) sonography has been introduced in clinical practice. This technique overcomes some limitations of conventional 2D sonography, allowing a more detailed assessment of morphologic features of the object studied, with no restriction to the number and orientation of the scanning plane.4 Several studies have evaluated the role of 3D transvaginal sonography in assessing adnexal masses, reporting controversial results. 5-8The issue of reproducibility is essential when proposing a new technique to be introduced into clinical practice. The objective of this study was to evaluate the reproducibility of 3D sonographic morphologic assessment of adnexal masses.

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Section: Discussionmentioning

confidence: 99%

Three-Dimensional Sonographic Morphologic Assessment of Adnexal Masses

Alcázar

García-Manero

Galván

2007

Journal of Ultrasound in Medicine

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“…In fact, increases in vascularity may influence the selection of a dominant, ovulatory follicle, whereas reduced vascularity may lead to follicular atresia , Augustin 2001, Reynolds et al 2002. In addition, reduction in the vascularity of follicles may decrease oocyte quality (Borini et al 2001, Mercé et al 2006. After ovulation, dramatic growth and vascularization of the ovulated follicle occur, transforming its structure into a developing CL.…”

Section: Introductionmentioning

confidence: 99%

Expression of endothelial nitric oxide synthase in the ovine ovary throughout the estrous cycle

Grazul-Bilska¹,

Navanukraw²,

Johnson³

et al. 2006

Reproduction

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This study was conducted to evaluate the expression of endothelial nitric oxide synthase (eNOS) in ovarian follicles and corpora lutea (CL) throughout the estrous cycle in sheep. Three experiments were conducted to (1) immunolocalize eNOS protein, (2) determine expression of mRNA for eNOS and its receptor guanylate cyclase 1 soluble b3 (GUCY1B3), and (3) co-localize eNOS and vascular endothelial growth factor (VEGF) proteins in the follicles and/or CL throughout the estrous cycle. In experiment 1, ovaries were collected from ewes treated with FSH, to induce follicular growth or atresia. In experiment 2, ovaries were collected from ewes treated with FSH and hCG to induce follicular growth and ovulation. In experiment 3, ovaries were collected from superovulated ewes to generate multiple CL on days 2, 4, 10, and 15 of the estrous cycle. In experiments 1 and 2, the expression of eNOS protein was detected in the blood vessels of the theca externa and interna of healthy ovarian follicles. However, in early and advanced atretic follicles, eNOS protein expression was absent or reduced. During the immediate postovulatory period, eNOS protein expression was detected in thecal-derived cells that appeared to be invading the granulosa layer. Expression of eNOS mRNA tended to increase in granulosa cells at 12 and 24 h, and in theca cells 48 h after hCG injection. In experiment 3, eNOS protein was located in the blood vessels of the CL during the estrous cycle. Dual localization of eNOS and VEGF proteins in the CL demonstrated that both were found in the blood vessels.

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“…6,8 Moreover, follicular volume measured by 3D US may be an independent factor for in vitro fertilization (IVF) and intracytoplasmic sperm injection outcome. [9][10][11] Our hypothesis is that the vascularization of the periovulatory follicle in patients undergoing IUI could help predict success in achieving pregnancy. Therefore, the aim of our study was to evaluate the relationship between volume and vascularization of the periovulatory follicle and subfollicular area measured by 3D PDUS, and ovulation and pregnancy in patients undergoing IUI.…”

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confidence: 99%

Periovulatory follicular volume and vascularization determined by 3D and power Doppler sonography as pregnancy predictors in intrauterine insemination cycles

Engels

Sanfrutos

Pérez-Medina

et al. 2011

J of Clinical Ultrasound

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Assessment of the ovarian volume, number and volume of follicles and ovarian vascularity by three-dimensional ultrasonography and power Doppler angiography on the HCG day to predict the outcome in IVF/ICSI cycles

Abstract: 3D ultrasonography and PDA allow for an easier ovarian assessment in IVF cycles. The predictive value of IVF outcome suggests a high clinical usefulness of this new technique.

Cited by 41 publications

References 31 publications

Three-Dimensional Sonographic Morphologic Assessment of Adnexal Masses

Three-Dimensional Sonographic Morphologic Assessment of Adnexal Masses

Expression of endothelial nitric oxide synthase in the ovine ovary throughout the estrous cycle

Periovulatory follicular volume and vascularization determined by 3D and power Doppler sonography as pregnancy predictors in intrauterine insemination cycles

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