Assessment of the Outcomes of Intrahepatic Cholangiocarcinoma After Ultrasound-Guided Percutaneous Microwave Ablation Based on Albumin–Bilirubin Grade

Yang, Hongcai; Cheng, Zhigang; Han, Zhiyu; Liu, Fangyi; Yu, Xiaoling; Yu, Jie; Liang, Ping

doi:10.1007/s00270-020-02637-9

Cited by 11 publications

(16 citation statements)

References 24 publications

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“…Our literature research revealed 11 papers analyzing the effect of microwave ablation for ICCA showing that MWA is feasible and safe [23,26,28,31,36]. The studies were all done retrospectively with small patient numbers.…”

Section: Discussionmentioning

confidence: 99%

“…The group concluded that MWA for ICCA ≤5 cm is safe as a treatment option in patients who are not candidates for surgery. Two studies looked at the outcomes of ICCA after MWA based on Albumin-Bilirubin grade (ALBI) [31,36]. The ALBI was used as a predictive value for long-term overall survival after MWA in ICCA patients.…”

Section: Mwa For Iccamentioning

confidence: 99%

“…Most of the included studies did not specifically address the effect of neo-adjuvant or adjuvant chemotherapy. Yang et al reported 11 patients who received an adjuvant therapy with gemcitabine and cisplatin after MWA but did not stratify the results accordingly [31]. Only the work by Takahashi et al…”

Section: Mwa For Iccamentioning

confidence: 99%

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The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma

Kim-Fuchs

Candinas

Lachenmayer

2021

JCM

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Background: The incidence and mortality of intrahepatic cholangiocarcinoma (ICCA) is increasing worldwide and curative treatment options are limited due to the aggressive tumor biology and often late diagnosis. Resection of the primary tumor remains the only curative therapy available, as the benefit of palliative chemotherapy and radiotherapy is relatively small. In contrast to hepatocellular carcinoma, minimal-invasive thermal tumor ablation, and in particular stereotactic tumor ablation for small primary cancers or metastases, is not established and data are scarce. Methods: We conducted a literature review in the field of ICCA ablation and retrospective analysis of 10 patients treated by stereotactic microwave ablation (SMWA) for either primary ICCA or liver metastases of ICCA. Results: While current guidelines have no consensus for ablation of primary ICCA, some state that it might be an option in inoperable patients or those with recurrent disease. The literature review revealed 11 studies on microwave ablation for ICCA reporting that MWA for ICCA ≤ 5 cm might be safe and could be a treatment option for patients who are not candidates for surgery. No data has been published on stereotactic microwave ablation (SMWA) for ICCA. The analyses of our own data of 10 patients treated by SMWA for primary ICCA (n = 5) or recurrent ICCA (n = 5) show that the treatment is safe and efficient with short hospital stays and low complication rates. Conclusion: Although thermal ablation, and in particular SMWA, might be a minimally invasive and tissue-sparing curative treatment alternative for small ICCA in the diseased liver and ICCA metastases, the oncologic benefit still needs to be shown in larger studies with longer follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Mwa For Iccamentioning

confidence: 99%

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The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma

Kim-Fuchs

Candinas

Lachenmayer

2021

JCM

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“…Similarly, a high ALBI (greater than −2.70) tended to have worse OS and RFS than a low ALBI (−2.70 or less) in this study. Several studies have also confirmed that a high ALBI has poor prognosis and is an independent risk factor for prognosis in patients with ICC(15,16). Additionally, the time-ROC curves showed that ALBI…”

mentioning

confidence: 83%

“…Several recent studies have demonstrated that the PNI and ALBI are closely related to the prognosis of patients with HCC, ICC, and gallbladder cancer (8)(9)(10)(11)(12)(13). Both the preoperative nutritional status and the immunological status have been reported to be independent prognostic factors of patients with ICC (11,(14)(15)(16). However, there is yet no conclusion on whether the combination of PNI and ALBI can improve the predictive ability of prognosis for ICC patients.…”

Section: Introductionmentioning

confidence: 99%

Prediction Efficacy of Prognostic Nutritional Index and Albumin–Bilirubin Grade in Patients With Intrahepatic Cholangiocarcinoma After Radical Resection: A Multi-Institutional Analysis of 535 Patients

Chen

Zhang

et al. 2021

Front. Oncol.

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BackgroundThe preoperative nutritional status and the immunological status have been reported to be independent prognostic factors of patients with intrahepatic cholangiocarcinoma (ICC). This study aimed to investigate whether prognostic nutritional index (PNI) + albumin–bilirubin (ALBI) could be a better predictor than PNI and ALBI alone in patients with ICC after radical resection.MethodsThe prognostic prediction evaluation of the PNI, ALBI, and the PNI+ALBI grade was performed in 373 patients with ICC who underwent radical resection between 2010 and 2018 at six Chinese tertiary hospitals, and external validation was conducted in 162 patients at four other Chinese tertiary hospitals. Overall survival (OS) and relapse-free survival (RFS) were estimated using the Kaplan–Meier method. Multivariate analysis was conducted to identify independent prognostic factors. A time-dependent receiver operating characteristic (ROC) curve and a nomogram prediction model were further constructed to assess the predictive ability of PNI, ALBI, and the PNI+ALBI grade. The C-index and a calibration plot were used to assess the performance of the nomogram models.ResultsUnivariate analysis showed that PNI, ALBI, and the PNI+ALBI grade were prognostic factors for the OS and RFS of patients with ICC after radical resection in the training and testing sets (p < 0.001). Multivariate analysis showed that the PNI+ALBI grade was an independent risk factor for OS and RFS in the training and testing sets (p < 0.001). Analysis of the relationship between the PNI+ALBI grade and clinicopathological characteristics showed that the PNI+ALBI grade correlated with obstructive jaundice, alpha-fetoprotein (AFP), cancer antigen 19-9 (CA19-9), cancer antigen 125 (CA125), PNI, ALBI, Child–Pugh grade, type of resection, tumor size, major vascular invasion, microvascular invasion, T stage, and N stage (p < 0.05). The time-dependent ROC curves showed that the PNI+ALBI grade had better prognostic predictive ability than the PNI, ALBI, and the Child–Pugh grade in the training and testing sets.ConclusionPreoperative PNI+ALBI grade is an effective and practical predictor for the OS and RFS of patients with ICC after radical resection.

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Microwave in the Treatment of Primary Liver Cancers

Chiang,

2023

Interventional Oncology

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Assessment of the Outcomes of Intrahepatic Cholangiocarcinoma After Ultrasound-Guided Percutaneous Microwave Ablation Based on Albumin–Bilirubin Grade

Cited by 11 publications

References 24 publications

The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma

The Role of Conventional and Stereotactic Microwave Ablation for Intrahepatic Cholangiocarcinoma

Prediction Efficacy of Prognostic Nutritional Index and Albumin–Bilirubin Grade in Patients With Intrahepatic Cholangiocarcinoma After Radical Resection: A Multi-Institutional Analysis of 535 Patients

Microwave in the Treatment of Primary Liver Cancers

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