Assessment of the occurrence of 455 pharmaceutical compounds in sludge according to their physical and chemical properties: A review

Continuous degradation of micropollutants in real world treated wastewaters by photooxidation in dynamic conditions

“…Organic contaminants analysis 1.1.1. Target contaminants All analytical and labelled standards used for quantification were certified standard powders or solutions of analytical-grade quality (purity > 98%) or certified reference materials (Supelco, Sigma Aldrich, Merck) (Sellier et al, 2022). Organic contaminants were chosen based on occurrence at WWTPs, whatever the focal matrix (solid or liquid phase; Verlicchi et al, 2012;Verlicchi & Zambello, 2015).…”

“…Since the end of the 19th century, several categories of emerging contaminants have emerged, largely due to scientific and analytical advances making it possible to detect them even at relatively low levels. Examples include hexabromocyclododecane (HBCD), organophosphorus flame retardants, per-and polyfluroalkyl (PFAS) substances, tetrabromobisphenol-A (TBBPA), and pharmaceutical residues (Cao et al, 2018;Coggan et al, 2019;Kumar et al, 2021;Sellier et al, 2022;Sunday et al, 2022). Pharmaceutical residues are a category of particular concern due to their broad therapeutic classes, physicochemical properties, modes of action, very large-scale distribution (e.g.…”

“…Pharmaceutical residues are a category of particular concern due to their broad therapeutic classes, physicochemical properties, modes of action, very large-scale distribution (e.g. Roig, 2018;Sellier et al, 2022), and associated risks. The behavior of pharmaceutical residues varies according to the physicochemical properties of each compound.…”

“…Generally speaking, lipophilic compounds are relatively retained in the solid phase and are more metabolized in the human body than hydrophilic compounds that are available in the liquid phase and better excreted from the body (e.g. Roig, 2018;Sellier et al, 2022). Various different treatment techniques are used to clean these pollutants, but their degradation performances remain insufficient, as a large panel of pharmaceutical compounds remain at detectable levels in the recipient media.…”

Environmental pharmacology—Dosing the environment: IUPHAR review 36

“…Beyond pesticides, environmental pharmacology would encompass all long‐lasting chemicals of environmental concern (CECs) that contaminate the environment such as bisphenol A, perfluoroalkyl substances and phthalates, all use widely in the food and manufacturing industries, as well as natural chemicals such as the neurotoxins and carcinogens released from some algal blooms. A further man‐made stressing of the environment arises from pharmaceuticals used to treat humans and farm animals, which can be released into the environment to pharmacologically relevant levels (Sellier et al, 2022 ) and which add an additional complication to an assessment of environmental dosing. Pharmacologists with experience in drug–target interactions can bring their knowledge to bear in a way that is not always evident in toxicological evaluations.…”