Assessment of the Non-Cystic Fibrosis Bronchiectasis Severity: The FACED Score vs the Bronchiectasis Severity Index

Abstract

Introduction : Non-cystic fibrosis bronchiectasis (NCFB) is a multidimensional disease, and no single isolated parameter is proved to have sufficient power for any overall determination of its severity and prognosis.Objective : To compare the results of the assessment of the NCFB severity with respect to its prognosis in the same patients by two different validated scores, i.e. the FACED score and the Bronchiectasis Severity Index (BSI).Methods : An observational study including 37 patients with NCFB (16 males and 21 female aged 46 to 76 years) was performed. All patients underwent evaluation of the variables incorporated in the FACED score (FEV1 % predicted, age, chronic colonization by Pseudomaonas aeruginosa, radiological extent of the disease, and dyspnea) and in the BSI (age, body mass index, FEV1 % predicted, hospitalization and exacerbations in previous year, dyspnea, chronic colonization by Pseudomaonas aeruginosa and other microrganisms, and radiological extent of the disease).Results : According to the value of the derived overall FACED score we found 17 patients (45.9%) with mild bronchiectasis, 14 patients (37.8%) with moderate bronchiectasis and 6 patients (16.2%) with severe bronchiectasis. The mean derived FACED score was 3.4 ± 1.3. In addition, according to the value of the derived overall BSI score, the frequency of patients with low, intermediate and high BSI score was 16 patients (43,2%), 14 patients (37.8%) and 7 patients (18.9%), respectively. The mean derived BSI score was 6.4 ± 2.5.Conclusion : We found similar results by the assessment of the NCFB severity in regard to its prognosis by both the FACED score and the BSI. Further studies determining how these scores may impact clinical practice are needed.

Serum Albumin and Disease Severity of Non-Cystic Fibrosis Bronchiectasis

“…We found a different pattern in terms of disease severity classification between the BSI and FACED instruments; 66.4% of our subjects were in the low FACED score group, whereas the low BSI group included only 13.1% of the subjects. The classifications of the systems were found to be comparable in a report of Minov et al, 26 which showed that 43.2 and 45.9% of subjects belonged to the low-BSI and low-FACED score groups, respectively. However, larger multi-center European cohorts showed that the subjects were predominantly classified as a moderate-to-severe group based on BSI classification, and a mild bronchiectasis group predominated according to the BSI classification.…”

Comparison of two prognostic scores (BSI and FACED) in a Spanish cohort of adult patients with bronchiectasis and improvement of the FACED predictive capacity for exacerbations

“…Minov et al[21] achieved a similar distribution of disease severity by BSI and FACED, but the study showed some underlying limitations, principally a small sample size (n = 37) and a low proportion of patients with PA chronic bronchial infection (8%). On the contrary, in a single-centre cohort of 91 patients with the same rate of chronic PA (22%)[18] and in a multicentre study[11] of 1612 patients, similar classification differences were found in the severity assessment, as we observed.…”

Phenotyping Adults with Non-Cystic Fibrosis Bronchiectasis: A 10-Year Cohort Study in a French Regional University Hospital Center

“…Thirty [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34] of the thirty-six reported series [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39] are smaller than ours. Half of them were retrospective.…”