Assessment of the mutagenic effect of 1,1-dimethyl hydrazine

Carlsen, Lars; Kenessov, Bulat; Batyrbekova, Svetlana; Kolumbaeva, S.; Shalakhmetova, Tamara

doi:10.1016/j.etap.2009.08.004

Cited by 33 publications

(9 citation statements)

References 6 publications

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“…As a comparison, the LD50 MMH is 15–33 mg kg −1 for MMH . As one can see, the mice show no sign of trouble a 300 mg kg −1 , suggesting its LD50 is way higher.…”

Section: Resultsmentioning

confidence: 91%

(E)‐1,1,4,4‐Tetramethyl‐2‐tetrazene (TMTZ): A Prospective Alternative to Hydrazines in Rocket Propulsion

Dhenain

Darwich

Sabaté

et al. 2017

Chemistry A European J

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1,1,4,4-Tetramethyl-2-tetrazene (TMTZ) is considered as a prospective replacement for toxic hydrazines used in liquid rocket propulsion. The heat of formation of TMTZ was computed and measured, giving values well above those of the hydrazines commonly used in propulsion. This led to a predicted maximum I of 337 s for TMTZ/N O mixtures, which is a value comparable to that of monomethylhydrazine. We found that TMTZ has a vapor pressure well below that of liquid hydrazines, and it is far less toxic. Finally, an improved synthesis is proposed, which is compatible with existing industrial production facilities after minor changes. TMTZ is thus an attractive liquid propellant candidate, with a performance comparable to hydrazines but a lower vapor pressure and toxicity.

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“…As a comparison, the LD50 MMH is 15–33 mg kg −1 for MMH . As one can see, the mice show no sign of trouble a 300 mg kg −1 , suggesting its LD50 is way higher.…”

Section: Resultsmentioning

confidence: 91%

(E)‐1,1,4,4‐Tetramethyl‐2‐tetrazene (TMTZ): A Prospective Alternative to Hydrazines in Rocket Propulsion

Dhenain

Darwich

Sabaté

et al. 2017

Chemistry A European J

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“…Обострение глобальной кризисной экологической ситуации связано с повсеместным загрязнением ОС различными химическими соединениями. Следствием накопления в ОС тяжелых металлов, пестицидов, по-верхностно-активных веществ, компонентов ракетного топлива становятся рост заболеваемости населения, де-стабилизация природных экосистем и снижение биоло-гического разнообразия [5][6][7][8][9]. Возникновение мутаций в зародышевых клетках приводит к выкидышам и вро-жденным порокам развития, в половых клетках -к воз-никновению наследственных заболеваний, а в соматиче-ских -к возникновению и развитию злокачественных новообразований [10,11].…”

Section: генетическая токсикологияunclassified

Genotoxic effects of N-nitrosodimethylamine in somatic and generative cells of mice

Lovinskaya

Владимировна²,

Kolumbayeva

et al. 2017

Ecological genetics

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N-Nitrosodimethylamine (NDMA) was shown to have genotoxic properties in acute and subacute studies on laboratory mice. The organ-specificity of the genotoxic effect of NDMA was revealed using the Comet assay. The most sensitive organs to the action of NDMA were kidneys and liver. DNA damage in liver cells of NDMA-treated animals at doses of 4.0 and 8.0 mg/kg, increased compared to control in 6.9 and 12.5 (р < 0.001), and in kidney cells – in 8.1 and 14.2 times (р < 0.001), respectively. NDMA also showed genotoxic activity in the reproductive cells of experimental animals, causing structural disorders of synaptonemal complexes in spermatocyte. In NDMA-treated animals at a dose of 2.0 mg/kg in acute and subacute studies, the level of spermatocytes with damaged synaptonemal complexes increased statistically significantly compared to control in 6.0 and 7.0 (р < 0.05) times, respectively.

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“…Unfortunately, MMH is toxic and persists long term in the environment. It displays genotoxic properties (methyl adducts formation, Ames test is positive in several strains of bacteria, and micronuclei increases) [1][2][3]. In addition, exposure to 0.05-0.5 ppm UDMH for acute-or intermediate-duration exposure is known to increase frequency of mice and rat cancers [4].…”

Section: Introductionmentioning

confidence: 97%

Quantification and kinetic study in plasma and tissues of (E)-1,1,4,4-tetramethyl-2-tetrazene, a liquid propellant and a transformation product of 1,1-dimethyl hydrazine

et al. 2015

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(E)-1,1,4,4-tetramethyl-2-tetrazene (TMTZ) is formed from the oxidation of the unsymmetrical 1,1-dimethylhydrazine (UDMH) and is used as a storable liquid fuel which can be considered as a new potential propellant for space rocket propulsion. To better understand the toxicological behavior of the compound, an intraperitoneal administration of TMTZ was performed in mice to define its toxicokinetics and tissue distribution. A fully validated liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) assay was developed to determine TMTZ levels in biological samples. Determination of TMTZ was achieved using 50 μL of plasma or tissue solution. Precipitation with ammonium sulfate and acetonitrile was used for sample preparation. Liquid chromatography was performed on an Atlantis HILIC Silica column (Waters; 3 μm, 150 mm × 2.1 mm i.d.). Isocratic elution with a mixture of ammonium acetate buffer (pH 5, 100 mM)/water/acetonitrile (3:2:95, v/v/v) was used. The detection was conducted using an electrospray source in positive ion mode. TMTZ and (15)N2-TMTZ (internal standard) were quantitated in selected reaction monitoring mode using the transition m/z 117→72 and 119→74, respectively. Standard curves exhibited excellent linearity in the range of 10-500 ng/mL for plasma and 50-2000 ng/mL for all tissues (heart, liver, brain, kidney, and lung) analyzed, and acceptable precision and accuracy (<10 %) were obtained. The elimination rate constant strongly suggests that TMTZ was very quickly eliminated from the body. The results of tissue distribution experiments indicated that TMTZ underwent a rapid distribution into limited organs such as the liver, kidney, and brain.

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Assessment of the mutagenic effect of 1,1-dimethyl hydrazine

Cited by 33 publications

References 6 publications

(E)‐1,1,4,4‐Tetramethyl‐2‐tetrazene (TMTZ): A Prospective Alternative to Hydrazines in Rocket Propulsion

(E)‐1,1,4,4‐Tetramethyl‐2‐tetrazene (TMTZ): A Prospective Alternative to Hydrazines in Rocket Propulsion

Genotoxic effects of N-nitrosodimethylamine in somatic and generative cells of mice

Quantification and kinetic study in plasma and tissues of (E)-1,1,4,4-tetramethyl-2-tetrazene, a liquid propellant and a transformation product of 1,1-dimethyl hydrazine

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