Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia

Jenkins, David; Kendall, Cyril W.C.; Faulkner, Dorothea; Nguyen, Tri H.; Kemp, T; Marchie, Augustine; Wong, Julia M W; Souza, Russell J. de; Emam, Azadeh; Vidgen, Edward; Trautwein, Elke A.; Lapsley, Karen G.; Holmes, Candice; Josse, Robert G.; Leiter, Lawrence A.; Connelly, Philip W.; Singer, William

doi:10.1093/ajcn.83.3.582

Cited by 159 publications

(93 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3 (SE 0 . 4) kg/m 2 ) participated in the 1-year free-living study in which they were provided with advice to follow the dietary portfolio (36) . Fifty-five subjects (83 %) completed the study.…”

Section: The Dietary Portfolio: Long-term Sustainabilitymentioning

confidence: 99%

“…6 (SE 2 . 1) % (36) . While the reductions achieved under 'real-world' conditions were found to be less than those observed under the tightly-controlled metabolic studies, > 30% of the subjects who were recruited into the study managed to achieve > 20% reductions in LDL-C (mean 29 .…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

“…20, P = 0 . 1232), possibly because the plant-sterol margarine was easy to comply with, did not displace unhealthy foods and the scatter in the data was not as great (36) . The study demonstrates that in a 'real-world' setting highly-motivated individuals can achieve cholesterol reductions with the dietary portfolio that are within the clinically-meaningful range based on early statin and prestatin drug criteria (37,38) .…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

See 2 more Smart Citations

Session 4: CVD, diabetes and cancer A dietary portfolio for management and prevention of heart disease

2009

View full text Add to dashboard Cite

CHD is the leading cause of worldwide mortality. The prevalence of heart disease has been linked to the adoption of a sedentary lifestyle and the increased dietary dependence on saturated fats from animal sources and the intake of refined foods. Elevated blood cholesterol level is one of the major risk factors for CHD. While cholesterol-lowering drug therapy (statins) has been effective in reducing the risk of heart disease, there are those individuals who are unwilling or because of muscle pains or raised levels of liver or muscle enzymes are unable to take cholesterol-lowering medication. Fortunately, there is evidence linking a number of dietary components to CHD risk reduction. The strength of this evidence has prompted various regulatory bodies to advocate diet as the first line of defence for primary prevention of heart disease. It was therefore decided to combine four dietary components that have been shown to lower blood cholesterol concentrations (nuts, plant sterols, viscous fibre and vegetable protein) in a dietary portfolio in order to determine whether the combined effect is additive. In a metabolically-controlled setting this dietary portfolio has proved to be as effective as a starting dose of a first-generation statin cholesterol-lowering medication in reducing the risk of CHD. The dietary portfolio has also been shown to be effective in sustaining a clinically-significant effect in the long term under a 'real-world' scenario. However, success of the diet depends on compliance and despite the accessibility of the foods adherence has been found to vary greatly. Overall, the evidence supports the beneficial role of the dietary portfolio in reducing blood cholesterol levels and CHD risk.

show abstract

Section: The Dietary Portfolio: Long-term Sustainabilitymentioning

confidence: 99%

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

See 1 more Smart Citation

Session 4: CVD, diabetes and cancer A dietary portfolio for management and prevention of heart disease

2009

View full text Add to dashboard Cite

show abstract

“…Before the study, participants were instructed to eat their routine therapeutic low-fat diets with mean macronutrient profiles (Table 2), which were close to current National Cholesterol Education Program adult treatment panel III (NCEP ATP III) guidelines (o7% energy from saturated fat and o200 mg/day dietary cholesterol) (Jenkins et al, 2006). Dietary advice for the 1-year ad libitum study was based on the consumption goals for the same four dietary components, which had been emphasized in previous metabolic dietary portfolio studies (Jenkins et al, , 2003(Jenkins et al, , 2005.…”

Section: Dietsmentioning

confidence: 99%

“…Since, in addition to lipid reduction, at least two of these components had potential blood pressure lowering properties (Dodson, 1980;Rivas et al, 2002;Kreijkamp-Kaspers et al, 2005;Streppel et al, 2005), we also considered it of interest to assess the effect of this diet on blood pressure as a key modifiable factor which together with blood lipids contribute to coronary heart disease (CHD) risk. The blood lipid data have been reported (Jenkins et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure

et al. 2007

View full text Add to dashboard Cite

Objective: To determine the effect on blood pressure of dietary advice to consume a combination of plant-based cholesterollowering foods (dietary portfolio). Methods: For 1 year, 66 hyperlipidemic subjects were prescribed diets high in plant sterols (1.0 g/1000 kcal), soy protein (22.5 g/1000 kcal), viscous fibers (10 g/1000 kcal) and almonds (22.5 g/1000 kcal). There was no control group. Seven-day diet record, blood pressure and body weight were monitored initially monthly and later at 2-monthly intervals throughout the study. Results: Fifty subjects completed the 1-year study. When the last observation was carried forward for non-completers (n ¼ 9) or those who changed their blood pressure medications (n ¼ 7), a small mean reduction was seen in body weight 0.770.3 kg (P ¼ 0.036). The corresponding reductions from baseline in systolic and diastolic blood pressure at 1 year (n ¼ 66 subjects) were À4.271.3 mm Hg (P ¼ 0.002) and À2.370.7 mm Hg (P ¼ 0.001), respectively. Blood pressure reductions occurred within the first 2 weeks, with stable blood pressures 6 weeks before and 4 weeks after starting the diet. Diastolic blood pressure reduction was significantly related to weight change (r ¼ 0.30, n ¼ 50, P ¼ 0.036). Only compliance with almond intake advice related to blood pressure reduction (systolic: r ¼ À0.34, n ¼ 50, P ¼ 0.017; diastolic: r ¼ À0.29, n ¼ 50, P ¼ 0.041). Conclusions: A dietary portfolio of plant-based cholesterol-lowering foods reduced blood pressure significantly, related to almond intake. The dietary portfolio approach of combining a range of cholesterol-lowering plant foods may benefit cardiovascular disease risk both by reducing serum lipids and also blood pressure.

show abstract

Dyslipidemia, Hypertension and Metabolic Syndrome

Burke¹,

Szapary²,

Deen

et al. 2007

The Complete Guide to Nutrition in Primary Care

View full text Add to dashboard Cite

Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia

Cited by 159 publications

References 60 publications

Session 4: CVD, diabetes and cancer A dietary portfolio for management and prevention of heart disease

Session 4: CVD, diabetes and cancer A dietary portfolio for management and prevention of heart disease

Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure

Dyslipidemia, Hypertension and Metabolic Syndrome

Contact Info

Product

Resources

About