Assessment of the Levels of Persistent Organic Pollutants and 1-Hydroxypyrene in Blood and Urine Samples from Mexican Children Living in an Endemic Malaria Area in Mexico

Trejo-Acevedo, Antonio; Rivero-Pérez, Norma E.; Flores-Ramírez, Rogelio; Orta-García, Sandra Teresa; Varela-Silva, José Antonio; Pérez-Maldonado, Iván N.

doi:10.1007/s00128-012-0593-z

Cited by 25 publications

(16 citation statements)

References 8 publications

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“…Urinary 1-OHPyr values of female subjects (influenced by the residential cooking on biomass fuels) were comparable to that measured in urinary samples of workers in coke oven industry, i.e., 2.3 μmol/mol-Cr (Jongeneelen 2001) and lower than those reported in children from endemic malarial zones in Mexico (i.e. 2.9 μmol/molCr) by Trejo-Acevedo et al (2012). The urinary 1-OHPyr values reported in this study of both cohorts were higher than those previously studies on the kitchen workers (1.25 median μmol/mol-Cr; Wang et al 2011), coke oven workers (1.8 μmol/mol-Cr, Rihs et al 2005), and sugarcane workers reported by Prado et al 2012 (1.27 μmol/mol-Cr) ( Table 3).…”

Section: Comparative Analyses Of Biomarkers Of Exposure and Effectsupporting

confidence: 49%

“…Unlike some previous studies on similar topic (Trejo-Acevedo et al 2012;Pruneda-Álvarez et al 2012;Ruíz-Vera et al 2014;Pérez-Maldonado et al 2014) which used only 1-OHPyr to evaluate human PAH exposure, in this study, urinary β-naphthol concentration was also measured as another biomarker for human exposure to wood smoke (Zelikoff et al 2002;Kato et al 2004;Kamal et al 2014Kamal et al , 2015a. Moreover, β-naphthol can be used as biomarker of recent naphthalene exposure, even at low levels (Kim et al 1999).…”

Section: Comparative Analyses Of Biomarkers Of Exposure and Effectmentioning

confidence: 89%

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Biomarkers of PAH exposure and hematologic effects in subjects exposed to combustion emission during residential (and professional) cooking practices in Pakistan

Kamal

Cincinelli

Martellini

et al. 2015

Environ Sci Pollut Res

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During the last decade, advances in analytical methods, an avalanche of information available over the Internet and a creation of international collaborations, have greatly increased our understanding of the role of trace elements in humans. Today, morbidity and mortality related to trace element deficiencies or toxicities affect more than half of the world's population. Research on both essential and toxic trace elements runs the gamut, from studies of dietary intake, requirements, and standards to optimal homeostasis and threshold values to genetic, molecular, and biochemical investigations of mechanisms of action. Specifically, trace elements are known to be involved in receptor, hormone, and enzyme functions, as well as genetics and derangements in disease.Disorders of trace element metabolism represent an important class of human diseases. The best known of these reflect abnormalities in iron, copper, or zinc metabolism. These diseases can lead to a deficiency of the metal in the tissues (e.g., matriptase-2 deficiency for iron, Menkes disease for copper, acrodermatitis enteropathica for zinc) or an excess (e.g., hemochromatosis for iron, Wilson's disease for copper). The adverse health effects resulting from trace element malnutrition have been almost completely solved in affluent countries with the exception of marginalized population groups, but deficiencies of trace element are still quite prevalent in less developed countries. Similarly, acute and chronic toxicity due to overexposure/pollution is a much more extensive problem in less developed countries than those that are affluent. Subclinical conditions of toxicity may be associated with a chronic low level occupational, environmental toxic exposure, or food toxicology and lead to insidious biological effects that indirectly affect health and disease risk.The propensity of a metal to be accumulated by living organisms depends on the affinity of the element for biological surfaces and its ability to cross external cell membranes, which, in turn, depends on its speciation. Once incorporated inside cells, the fate of the metal and its effects will depend on the ability of the organism to detoxify, and ultimately, eliminate the metal. Metals inappropriately bound to sensitive subcellular components, such as mitochondria or metabolic enzymes, can lead to oxidative stress and substantial metabolic costs. Each species within a food web possesses its own capacity for metal accumulation, storage, detoxification, and elimination. This species-specific response, combined with behavioral and ecological considerations of predator-prey interactions, greatly affects the capacity of metals to efficiently transfer along food webs and to induce toxicity.The present issue of ESPR contains selected articles contributed by speakers at the International Seminar BEcotoxicology and toxicology: problems and decisions.T he meeting was held in Rovaltain, Alixan, France, on 26 November 2015 and was organized by Trace ElementInstitute for UNESCO (TEU) and Foundation Rovaltain, in...

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Section: Comparative Analyses Of Biomarkers Of Exposure and Effectsupporting

confidence: 49%

Section: Comparative Analyses Of Biomarkers Of Exposure and Effectmentioning

confidence: 89%

Biomarkers of PAH exposure and hematologic effects in subjects exposed to combustion emission during residential (and professional) cooking practices in Pakistan

Kamal

Cincinelli

Martellini

et al. 2015

Environ Sci Pollut Res

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“…It is important to remember that humans are usually exposed to complex chemical mixtures rather than to individual compounds (Domínguez-Cortinas et al, 2013;Perez-Maldonado et al, 2004Orta-Garcia et al, 2014;Trejo-Acevedo et al, 2012). Moreover, it was noted that populations are exposed to proinflammatory compounds (as DDE and PCB153) and compounds such as PAHs, PCBs, and TCCD (AhR agonists) simultaneously (Costilla-Salazar et al, 2011;Martínez-Salinas et al, 2011;PerezMaldonado et al, 2013;Trejo-Acevedo et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it was noted that populations are exposed to proinflammatory compounds (as DDE and PCB153) and compounds such as PAHs, PCBs, and TCCD (AhR agonists) simultaneously (Costilla-Salazar et al, 2011;Martínez-Salinas et al, 2011;PerezMaldonado et al, 2013;Trejo-Acevedo et al, 2012). Thus, it is important to assess potential toxicological interactions between components of a chemical mixture in exposed populations.…”

Section: Discussionmentioning

confidence: 99%

DDE and PCB 153 independently induce aryl hydrocarbon receptor (AhR) expression in peripheral blood mononuclear cells

Gaspar-Ramírez

Pérez‐Vázquez

Salgado‐Bustamante³

et al. 2014

Journal of Immunotoxicology

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Recent studies have demonstrated that compounds inducing pro-inflammatory cytokines enhance AhR expression. The aim of this study was 2-fold: (1) to determine if two pro-inflammatory compounds, dichlorodiphenyldichloroethylene (DDE) and 2,2 0 ,4,4 0 ,5,5 0 -hexa-chlorobiphenyl (PCB 153), independently affect AhR gene expression in peripheral blood mononuclear cells (PBMC); and (2) if affected, to determine whether the mechanism involved was due to AhR activation or to a pro-inflammatory effect of the chemicals. PBMC isolated from healthy individuals were incubated in the presence of DDE (10 mg/ml) and PCB 153 (20 ng/ml) over time and AhR and CYP1A1 expression was assessed with a real-time PCR technique. The results indicated there was over-expression of the AhR mRNA in PBMC when the cells were treated with DDE and PCB 153. No changes in expression levels of CYP1A1 mRNA were found. Importantly, when the cells were exposed to DDE and PCB 153 in the presence of an antagonist of tumor necrosis factor (TNF)-, the over-expression of AhR was abolished; as expected, the expression of CYP1A1 was unaffected. In conclusion, these studies demonstrated for the first time an increment of AhR expression ''in vitro'' in PBMC treated with two pro-inflammatory environmental pollutants, DDE and PCB153. Moreover, the over-expression of AhR was dependent of TNF induced by DDE and PCB 153 and was independent of AhR activation.

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“…There are still other studies that focus on children's exposure to PAHs. [50][51][52][53][54][55][56][57][58][59] The present study aims to assess the exposure of PAHs by simultaneously analysing 2-hydroxynaphthalene, 2-hydoxyfluorene, 9-hydroxyphenanthrene, 1-hydroxypyrene and 3-hydroxybenz[a]pyrene in urine from student volunteers living in urban and rural areas in Southern China.…”

Section: Introductionmentioning

confidence: 99%

Urinary monohydroxylated metabolites of polycyclic aromatic hydrocarbons in children living in city and rural residences in Southern China

Wang

Fan

Dong

et al. 2014

Environmental Technology

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Urinary 2-hydroxynaphthalene, 2-hydoxyfluorene, 9-hydroxyphenanthrene, 1-hydroxypyrene and 3-hydroxybenz[a]pyrene concentrations in 179 randomly selected voluntary students were determined in the Southern China, aged 14-16 and living in four areas with different levels of polycyclic aromatic hydrocarbons (PAHs) in soil, water and ambient air. The excretion of 1-hydroxypyrene is significantly higher in students of the urban than in students of the rural, while there are no significant differences of urinary 2-hydroxynaphthalene, 2-hydoxyfluorene and 9-hydroxyphenanthrene between urban and rural children. Mean concentrations of 1-hydroxypyrene (0.54-0.80 μmol/mol creatinine) in the study are much higher than those in the children of Denmark, Germany, Spain, USA, Korea, Japan and Taiwan, and a little higher than those in the children of Ukraine and Thailand. Urinary 2-hydroxynaphthalene concentrations in the study are a little higher than those in the children of USA, and similar to that in non-occupational exposure residences in Korea. Urinary 9-hydroxyphenanthrene concentrations in China are much higher than those in the children of USA. Differences between children with smoking parents and non-smoking parents are not significant in the study.

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Assessment of the Levels of Persistent Organic Pollutants and 1-Hydroxypyrene in Blood and Urine Samples from Mexican Children Living in an Endemic Malaria Area in Mexico

Cited by 25 publications

References 8 publications

Biomarkers of PAH exposure and hematologic effects in subjects exposed to combustion emission during residential (and professional) cooking practices in Pakistan

Biomarkers of PAH exposure and hematologic effects in subjects exposed to combustion emission during residential (and professional) cooking practices in Pakistan

DDE and PCB 153 independently induce aryl hydrocarbon receptor (AhR) expression in peripheral blood mononuclear cells

Urinary monohydroxylated metabolites of polycyclic aromatic hydrocarbons in children living in city and rural residences in Southern China

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