Assessment of the Lateral Diffusion and Penetration of Topically Applied Drugs in Humans Using a Novel Concentric Tape Stripping Design

Gee, Carol Maying; Nicolazzo, Joseph A.; Watkinson, Adam C.; Finnin, Barrie C.

doi:10.1007/s11095-012-0731-7

Cited by 29 publications

(32 citation statements)

References 41 publications

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“…benzyl alcohol into the clamped parts of the diffusion cell has been assumed previously [34]. In agreement with the results from Gee et al [3], which determined the lateral transport of CAF, hydrocortisone, and ibuprofen, the lipophilic FFA exhibited a lower tendency to move laterally than the hydrophilic CAF. From the microscopic pictures (Fig.…”

Section: Discussionsupporting

confidence: 85%

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Finite dose skin mass balance including the lateral part: Comparison between experiment, pharmacokinetic modeling and diffusion models

Selzer

Hahn

Naegel

et al. 2013

Journal of Controlled Release

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Section: Discussionsupporting

confidence: 85%

“…Due to the limited amount of substance, the transient character may lead to a substantial deviation from the steadystate situation that is characteristic for an infinite dose setting. In this context, in particular the role of the lateral compartment in experimental studies has recently gained some attention [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Finite dose skin mass balance including the lateral part: Comparison between experiment, pharmacokinetic modeling and diffusion models

Selzer

Hahn

Naegel

et al. 2013

Journal of Controlled Release

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“…This active shows potential anticancer effects upon oral and topical administration, and is able to protect the skin from ultraviolet (UV) light induced skin cancer (Dias et al, 1999;Koo et al, 2007;Lu et al, 2007;Roure et al, 2011;Gee et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Design of solid lipid nanoparticles for caffeine topical administration

et al. 2014

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Caffeine is an interesting compound showing anticancer and protective effects upon topical administration, although its penetration through the skin is compromised by its hydrophilicity. Materials and methods: SLN-CAF were formulated by using a modification of the quasi-emulsion solvent diffusion technique (QESD) and characterized by PCS and DSC analyses. In vitro percutaneous absorption studies were effected using excised human skin membranes (i.e. Stratum Corneum Epidermis or SCE).Results: SLN-CAF were in a nanometric range (182.6 ± 8.4 nm) and showed an interesting payload value (75% ± 1.1). DSC studies suggest the presence of a well-defined system and the successful drug incorporation. Furthermore, SLN-CAF generated a significantly faster permeation than a control formulation over 24 h of monitoring. Discussion and conclusions: SLN-CAF were characterized by valid dimensions and a good encapsulation efficiency, although the active to incorporate showed a hydrophilic character. This result confirms the suitability of the formulation strategy employed in the present work. Furthermore, the in vitro evidence outline the key role of lipid nanoparticles in enhancing caffeine permeation through the skin.

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“…Although a number of methods have been previously evaluated as transdermal drug delivery enhancers, these methods are associated with a number of drawbacks, including low efficacy, limitations regarding molecular weight (<500 Da), high lipophilicity and skin irritation (25,26). Consequently, overcoming the skin barrier in a safe and effective way remains to be a difficulty in the development of novel transdermal drug delivery systems.…”

Section: Discussionmentioning

confidence: 99%

Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in�vivo and in�vitro study

Yoo

Kwon

et al. 2020

Exp Ther Med

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Penetration of any compound into the body from the outside is prevented primarily by the corneal layer of the epidermis. The only way to circumvent the properties of the corneal layer is to disrupt it. Currently, transdermal systems can currently only deliver drugs that are of low molecular weight. The purpose of the present study was to assess the improvement of the slimming cream's efficacy using a novel fabric, with the aim of developing an improved method for transdermal drug delivery. The current study was conducted on four groups of guinea pigs. The control group was untreated, whereas the test groups were treated with either slimming cream and no fabric, slimming cream with 100% cotton fabric or slimming cream with the novel fabric. Ultrasound and microscopic histological analysis were used to assess animals. The results demonstrated that compared with the other groups, the novel fabric group demonstrated the greatest reductions in fat layer thickness, adipocyte size and number and proliferator-activated receptor-γ levels in adipose tissue. Furthermore, the novel fabric also enhanced the transdermal delivery of rhodamine B base and caffeine penetration compared with the control fabric (3.18-fold). In conclusion, the results of the present study demonstrated that the novel fabric can potentially be used to enhance transdermal drug delivery.

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Assessment of the Lateral Diffusion and Penetration of Topically Applied Drugs in Humans Using a Novel Concentric Tape Stripping Design

Abstract: Drug concentration decreased with increased lateral distance from the application site. The lower recovery of IBU in the upper tape strip regions compared to CAF and HC may be a consequence of greater penetration into the SC with time.

Cited by 29 publications

References 41 publications

Finite dose skin mass balance including the lateral part: Comparison between experiment, pharmacokinetic modeling and diffusion models

Finite dose skin mass balance including the lateral part: Comparison between experiment, pharmacokinetic modeling and diffusion models

Design of solid lipid nanoparticles for caffeine topical administration

Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in�vivo and in�vitro study

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