Assessment of the Immune Response Phenotype in Patients With Surgical Sepsis Depending on the Course and Outcomes of the Disease

Abstract

Sepsis remains one of the biggest problems of modern medicine throughout the world. Timely determination of the phenotype of the patient’s immune response will be critical to making early therapeutic decisions. Analysis of the content of Treg and TNF-α, IL-6, IL10, TGF-β in patients with sepsis, depending on the severity of organ dysfunction in the dynamics of the disease was carried out. There was a direct correlation of moderate strength between the blood levels of IL-10 and Treg (R = 0.54, p<0.05). High levels of Treg, IL-10 content reflect the immunosuppressive phenotype of the immune response in the late stages and is a prognostic criterion for an unfavorable outcome in sepsis.