Assessment of the greenness of spectrophotometric and micellar liquid chromatographic methods using two approaches: Application to pharmaceutical analysis of hydrochlorothiazide and telmisartan

Ibrahim, F.; El-Brashy, A.; El-Awady, Mohamed I.; Abdallah, Nora A.

doi:10.1016/j.microc.2019.04.058

Cited by 18 publications

(3 citation statements)

References 22 publications

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“…Difference Spectrophotometry, Q-Absorbance Method [8] Allopurinol and Lesinurad Simultaneous Equation Method [9] Ambroxol, Salbutamol, and Theophylline Simultaneous Equation Method [10] Bromfenac and Ofloxacin Derivative Spectrophotometry [11] Esomeprazole and Naproxen Derivative Spectrophotometry [12] Fluorescein and Benoxinate Simultaneous Equation Method [13] Fluticasone and Formoterol Simultaneous Equation Method, Q-Absorbance Method [14] Furazolidone and Metronidazole Q-Absorbance Method [15] Hydrochlorothiazide and Carvedilol Q-Absorbance Method [16] Ledipasvir and Sofosbuvir Derivative Spectrophotometry [17] Levosulpiride and Rabeprazole sodium Derivative Spectrophotometry [18] Metformin HCl and Anagliptin Q-Absorbance Method [19] Nalidixic acid and Metronidazole Difference Spectrophotometry [20] Pamabrom, Mefenamic Acid, and Dicyclomine Hydrochloride Simultaneous Equation Method [21] Quinfamide and Mebendazole Q-Absorbance Method [22] Sofosbuvir and Velpatasvir Simultaneous Equation Method [23] Sumatriptan and Naproxen Simultaneous Equation Method [24] Telmisartan and Hydrochlorothiazide Q-Absorbance Method [25] Tinidazole and Norfloxacin Difference Spectrophotometry [26] Β-Carotene and Lycopene Simultaneous Equation Method [27] Paracetamol Paracetamol (PCM), widely known as Acetaminophen is an OTC medicine having analgesic and antipyretic properties used in mild to moderate pain and fever. It is chemically N-(4-hydroxyphenyl) acetamide (Figure 5).…”

Section: Acetaminophen and Chlorzoxazonementioning

confidence: 99%

A Review on Methods Developed for Estimation of Paracetamol in Combination with Other Drugs

Baghel¹,

Shah²

2023

Int J Pharm Res Allied Sci

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In this ever-growing world, it is crucial to improve upon the formulations in terms of potency, patient acceptability, fewer side effects, and quicker relief. Due to these requirements, the market is flooded with various combination dosage forms, with a constant increase in number. Paracetamol is a commonly used non-steroidal anti-inflammatory drug (NSAID) that has antipyretic and analgesic action. This drug is available in a wide range of combinations. It acts by inhibiting the production of prostaglandins, which combat pain and inflammation. A simultaneous multicomponent analysis is used to determine the estimation of medicines that are available in combination. Different analytical techniques are available for their determination, one of which includes the use of UV spectrophotometric methods. This review focuses on a variety of paracetamol combinations with drugs like Domperidone, Aceclofenac, Diclofenac Sodium, Etodolac, Ibuprofen, Piroxicam, Caffeine, Aspirin, and their simultaneous estimation by different UV methods viz. Simultaneous equation method, Absorbance ratio (Q-Analysis), Difference spectrophotometry, Derivative spectroscopy method, and a few other chemometric methods. This manuscript would provide the platform to have exhaustive literature on methods used for the estimation of paracetamol with different drugs using a spectrophotometer. It would help the researchers and scholars who are working in the area.

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Section: Acetaminophen and Chlorzoxazonementioning

confidence: 99%

A Review on Methods Developed for Estimation of Paracetamol in Combination with Other Drugs

Baghel¹,

Shah²

2023

Int J Pharm Res Allied Sci

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“…Liquid chromatography is one of the most harmful techniques, as it uses high amounts of harmful organic solvents 28 . So, one of the main targets of greening chromatography is a solvent-reducing approach, where the most common mobile phases containing methanol are replaced by less harmful and more ecofriendly alternatives, such as water, ethanol and isopropanol 29 .…”

Section: Introductionmentioning

confidence: 99%

A quality-by-design eco-friendly UV-HPLC method for the determination of four drugs used to treat symptoms of common cold and COVID-19

Abdallah

Fathy

Tolba

et al. 2023

Sci Rep

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An optimization approach based on full factorial design was employed for developing an HPLC–UV method for simultaneous determination of a quaternary mixture used for the treatment of symptoms related to common cold and COVID-19. The quaternary mixture is composed of paracetamol, levocetirizine dihydrochloride, phenylephrine hydrochloride and ambroxol hydrochloride. The developed technique is a green, fast and simple method that uses isocratic elution of mobile phase consisting of 20:5:75 (v/v) of ethanol: acetonitrile: 2.5 mM heptane-1-sulphonic acid sodium salt at pH 6.5 $$\pm$$ ± 0.02. The chromatographic separation was carried out using Hypersil BDS Cyano LC Column (250 × 4.6 mm, 5 μm) with 230 nm UV detection and 1.0 mL/min. flow rate. Avoiding the routine methodology and resorting to the modern technology—represented in the usage of experimental design—allows rapid determination of the four drugs using the optimum quantity of chemicals to avoid any waste of resources. The quaternary mixture was eluted in less than 9 min., where retention times of paracetamol, levocetirizine dihydrochloride, phenylephrine hydrochloride and ambroxol hydrochloride were found to be 2.2, 3.8, 6.6 and 8.8 min., respectively. The calibration graphs of the four drugs were linear over concentration ranges of 50.0–500.0, 0.5–20.0, 0.5–20.0 and 0.5–100.0 µg/mL for paracetamol, levocetirizine dihydrochloride, phenylephrine hydrochloride and ambroxol hydrochloride, respectively with correlation coefficients higher than 0.999. The method is accurate with mean recoveries between 99.87 and 100.04%, precise, as %RSD for the intraday and interday precision were between 0.61 and 1.64% and very sensitive with limit of detections (LOD)’s between 29 and 147 ng/mL and limit of quantification (LOQ)’s between 95 and 485 ng/mL. The proposed method was successfully applied for the analysis of the four drugs either in raw materials or in prepared tablet with the least amount of chemicals within short time. It is also validated following International Conference on Harmonization Guidelines. The proposed method was found to be green according to the most common greenness assessment tools; NEMI, GAPI, Analytical Eco-Scale and AGREE methods. The advantages of the proposed method qualify it for routine analysis of the studied drugs either in single or co-formulated dosage form in quality control labs.

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“…Spectrophotometry 22,23 , spectrofluorimetry 24 , HPLC 22,25,26 , HPTLC 27 and UPLC 28 techniques were utilized for the estimation of TEL in its pharmaceutical preparations and biological fluids.…”

mentioning

confidence: 99%

Green fluorometric strategy for simultaneous determination of the antihypertensive drug telmisartan (A tentative therapeutic for COVID-19) with Nebivolol in human plasma

Salim

Radwan

Hadad

et al. 2023

Sci Rep

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Telmisartan (TEL) and Nebivolol (NEB) are frequently co-formulated in a single dosage form that is frequently prescribed for the treatment of hypertension, moreover, telmisartan is currently proposed to be used to treat COVID19-induced lung inflammation. Green rapid, simple, and sensitive synchronous spectrofluorimetric techniques for simultaneous estimation of TEL and NEB in their co-formulated pharmaceutical preparations and human plasma were developed and validated. Synchronous fluorescence intensity at 335 nm was used for TEL determination (Method I). For the mixture, the first derivative synchronous peak amplitudes (D1) at 296.3 and 320.5 nm were used for simultaneous estimation of NEB and TEL, respectively (Method II). The calibration plots were rectilinear over the concentration ranges of 30–550 ng/mL, and 50–800 ng/mL for NEB and TEL, respectively. The high sensitivity of the developed methods allowed for their analysis in human plasma samples. NEB`s Quantum yield was estimated by applying the single-point method. The greenness of the proposed approaches was evaluated using the Eco-scale, National Environmental Method Index (NEMI), and Green Analytical Procedure Index (GAPI) methods.

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Assessment of the greenness of spectrophotometric and micellar liquid chromatographic methods using two approaches: Application to pharmaceutical analysis of hydrochlorothiazide and telmisartan

Cited by 18 publications

References 22 publications

A Review on Methods Developed for Estimation of Paracetamol in Combination with Other Drugs

A Review on Methods Developed for Estimation of Paracetamol in Combination with Other Drugs

A quality-by-design eco-friendly UV-HPLC method for the determination of four drugs used to treat symptoms of common cold and COVID-19

Green fluorometric strategy for simultaneous determination of the antihypertensive drug telmisartan (A tentative therapeutic for COVID-19) with Nebivolol in human plasma

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