Assessment of the Epidemiology and Burden of Measles in Southern Mozambique

Mandomando, Inácio; Naniche, Denise; Pasetti, Marcela F.; Cuberos, Lilian; Sanz, Sergi; Vallès, Xavier; Sigaùque, Betuel; Macete, Eusébio; Nhalungo, Delino; Kotloff, Karen L.; Levine, Myron M.; Alonso, Pedro L.

doi:10.4269/ajtmh.2011.10-0517

Cited by 15 publications

(14 citation statements)

References 29 publications

(41 reference statements)

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“…Malawi reported fewer deaths from measles than did other African countries where measles outbreaks recently occurred ( 13 – 15 ). Although measles-related deaths are known to be underreported, perhaps the best explanation for low numbers of reported deaths is the high measles vaccine coverage combined with the lower CFR among vaccinated case-patients ( 16 , 17 ).…”

Section: Lessons Learnedmentioning

confidence: 95%

Lessons and Challenges for Measles Control from Unexpected Large Outbreak, Malawi

Minetti¹,

Kagoli

Katsulukuta

et al. 2013

Emerg. Infect. Dis.

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Section: Lessons Learnedmentioning

confidence: 95%

Lessons and Challenges for Measles Control from Unexpected Large Outbreak, Malawi

Minetti¹,

Kagoli

Katsulukuta

et al. 2013

Emerg. Infect. Dis.

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“…In 2011, three [3] LGAs (13%) had proportions lower than the 80% recommended target. While in 2012, five [5] LGAs (22%), had proportion lower than the recommended target.…”

Section: Usefulnessmentioning

confidence: 99%

“…Measles is an acute viral infectious disease and an important cause of childhood morbidity and mortality [1][2][3][4][5]. In 2010, the estimated annual measles incidence aggregated across all countries was 1.6 cases per 1000, resulting in about 139,000 deaths globally [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Measles Surveillance System in Kaduna State, Nigeria (2010-2012)

Ameh

Sufiyan

Jacob

et al. 2016

OJPHI

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Objective: To evaluate the case-based measles surveillance system in Kaduna State of Nigeria and identify gaps in its operation.Introduction: In Africa, approximately 13 million cases, 650,000 deaths due to measles occur annually, with sub-Saharan Africa having the highest morbidity and mortality. Measles infection is endemic in Nigeria and has been documented to occur all year round, despite high measles routine and supplemental immunization coverage. The frequent outbreaks of measles in Kaduna State prompted the need for the evaluation of the measles case-based surveillance system.

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“…Generally, the literature shows that measles continues to affect African countries [32, 33]. The disease remains a killer among vaccine-preventable diseases, especially among children of developing countries [34, 35].…”

Section: Discussionmentioning

confidence: 99%

Indirect costs associated with deaths of children aged 0–14 years from measles in a weak health system and conflict and fragile zone: the case of Somalia

Da’ar

2019

Epidemiol. Infect.

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This study recognises periodic outbreaks of measles continue to affect conflict and fragile zones in the least developed countries. This study set out to provide evidence for the indirect costs or economic loss associated with measles-related deaths among children aged 0–14 years in Somalia. Using epidemiologic and economic data, the indirect cost was calculated based on the framework of the World Health Organisation guide of identifying the economic consequences of disease and injury. The baseline indirect cost was computed as the product of discounted future productive years of life lost (PYLL), non-health gross domestic product per capita (NHGDPPC) and the estimated total measles deaths (ETMD). The model was adjusted for conflict and fragility conditions and further extension considered a finite and stable upper limit growth of the instability-adjusted NHGDPPC. To discount future costs, a rate of 3% was applied. Using a ±20% variability assumption of the epidemiologic and economic factor inputs, a sensitivity analysis was conducted to account for uncertainty. In 2015 values, the ETMD of 3723 measles deaths of children aged 0–14 years could decrease non-health GDP of the country by $23.46 million, a potential loss of $6303 per death over the discounted PYLL. The loss would increase by 5.3% when adjusted for conflict and fragility conditions. Assuming growth, the future adjusted loss is expected to be $35.91 million in 2015 values. Girl-child deaths accounted for 51.2% of the burden. Results are robust to the variations in the model inputs, although sensitivity analyses suggest the proportion of total measles deaths and the discount rate accounted for greater uncertainty of the loss than do the proportion of growth and instability assumption. Conflict and fragility accounted for the least uncertainty, perhaps confirming their relative perpetuity in Somalia. Results show significant indirect cost related to measles deaths of children, exacerbated by conflict and fragility. This is an economic burden, but one which the health system, policy-makers, government and other stakeholders should be prepared to colossally discount by collectively taking measles surveillance and security measures now to reduce further deaths in the future.

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Assessment of the Epidemiology and Burden of Measles in Southern Mozambique

Cited by 15 publications

References 29 publications

Lessons and Challenges for Measles Control from Unexpected Large Outbreak, Malawi

Lessons and Challenges for Measles Control from Unexpected Large Outbreak, Malawi

Evaluation of the Measles Surveillance System in Kaduna State, Nigeria (2010-2012)

Indirect costs associated with deaths of children aged 0–14 years from measles in a weak health system and conflict and fragile zone: the case of Somalia

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