Assessment of the environmental fate and effects of ivermectin in aquatic mesocosms

Sanderson, Hans; Laird, Brian; Pope, Louise; Brain, Richard A.; Wilson, Christian J.; Johnson, D. J.; Bryning, Gareth; Peregrine, Andrew S.; Boxall, Alistair B.A.; Solomon, Keith R.

doi:10.1016/j.aquatox.2007.08.011

Cited by 115 publications

(94 citation statements)

References 34 publications

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“…This pseudopersistence must be considered in developing tools to characterize effects. Another issue is that, with a few exceptions such as parasiticides (19), pharmaceuticals are not designed to be highly acutely toxic to the organism in which they are used and therefore are usually not acutely lethal to non-target animals, although plants may be affected (20). The effects of pharmaceuticals may not be easily observed unless they produce clear biomarker responses, such as have been observed in fish exposed to estradiol, estrone, and ethinyl estradiol from STPs (21).…”

Section: Problem Formulation and Special Considerations For Pharmaceumentioning

confidence: 99%

“…Other pharmaceuticals, such as the selective serotonin reuptake inhibitors have been shown to be toxic to algae (17), affect behavior in pelagic animals (46), and reproduction (18) but the relevance of this at the population level or in the field is still uncertain. The antiparisiticide, avermectin, (also used an insecticide) has been demonstrated to cause changes in ecosystem structure and function at concentrations ≥30 ng/L, below the predicted environmental concentration (19), suggesting the potential for adverse effects, however, the current paucity of measures of environmental concentrations prevents the use of a full environmental risk assessment.…”

Section: General Conclusionmentioning

confidence: 99%

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Risks of agricultural pharmaceuticals in surface water systems and soils

Solomon¹,

Hillis²,

Lissemore³

et al. 2009

ACS Symposium Series

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Section: Problem Formulation and Special Considerations For Pharmaceumentioning

confidence: 99%

Section: General Conclusionmentioning

confidence: 99%

Risks of agricultural pharmaceuticals in surface water systems and soils

Solomon¹,

Hillis²,

Lissemore³

et al. 2009

ACS Symposium Series

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“…[1] Numerous studies have been conducted on the environmental fate of avermectins with a focus on effects on dung arthropods, [5] soil invertebrates, [6][7] and aquatic ecosystems. [8] Studies looking at the mobility [9] and dissipation [10] of ivermectin in different soil types have shown that pH and cation exchange capacity of the soil can affect the ionic binding potential of ivermectin, and that the dissipation of ivermectin is slow in many soils under aerobic conditions. To our knowledge, there are no studies examining the transport of ivermectin in pastureland surface waters.…”

Section: Introductionmentioning

confidence: 99%

Transport of oxytetracycline, chlortetracycline, and ivermectin in surface runoff from irrigated pasture

Bair

Popova

Tate

et al. 2017

Journal of Environmental Science and Health, Part B

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The transport of oxytetracycline, chlortetracycline, and ivermectin from manure was assessed via surface runoff on irrigated pasture. Surface runoff plots in the Sierra Foothills of Northern California were used to evaluate the effects of irrigation water application rates, pharmaceutical application conditions, vegetative cover, and vegetative filter strip length on the pharmaceutical discharge in surface runoff. Experiments were designed to permit the maximum potential transport of pharmaceuticals to surface runoff water, which included pre-irrigation to saturate soil, trimming grass where manure was applied, and laying a continuous manure strip perpendicular to the flow of water. However, due to high sorption of the pharmaceuticals to manure and soil, less than 0.1% of applied pharmaceuticals were detected in runoff water. Results demonstrated an increase of pharmaceutical transport in surface runoff with increased pharmaceutical concentration in manure, the concentration of pharmaceuticals in runoff water remained constant with increased irrigation flow rate, and no appreciable decrease in pharmaceutical runoff was produced with the vegetative filter strip length increased from 30.5 to 91.5 cm. Most of the applied pharmaceuticals were retained in the manure or within the upper 5 cm of soil directly beneath the manure application sites. As this study evaluated conditions for high transport potential, the data suggest that the risk for significant chlortetracycline, oxytetracycline, and ivermectin transport to surface water from cattle manure on irrigated pasture is low.

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“…Portanto, no presente estudo, embora os tratamentos com runoff tivessem potencial para o aumento na produção do fitoplâncton devido à disponibilidade de nutrientes, a limitação da luz pelos sólidos suspensos impediu esse crescimento. (SANDERSON et al, 2007).…”

Section: Ensaios Ecotoxicológicos Com Abamectina Utilizandounclassified

Efeitos do agrotóxico Vertimec no fitoplâncton: um estudo laboratorial e "in situ"

Vieira¹

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Efeitos do agrotóxico Vertimec® no fitoplâncton: um estudo laboratorial e "in situ"São Carlos -SP AGRADECIMENTOSAo Prof. Evaldo pela confiança e absolto apoio ao trabalho.À CAPES pela bolsa concedida.À Maria José Dellamano pela contribuição na identificação do material fitoplânctonico e nos procedimentos de laboratório.À a Prof. Odete pela contribuição ao trabalho.As amigas Andréa Novelli, Andréa Braun, Anna Maria Vasconcelos, Maria Edna Nunes e Patrícia Giloni pelo trabalho em equipe que permitiu a realização deste trabalho e pela amizade.As colegas Natália F. Negreiros e Renata M. dos Santos pela ajuda no laboratório. Aos técnicos Marcelo Menezes Nogueira e Amândio Menezes Nogueira que contribuíramintensamente para a realização deste trabalho.Aos funcionários do CRHEA.À minha mãe e aos meus irmãos, que são a minha base e o meu alento.Ao Marco Aurélio pelo carinho, incentivo e alegria.Aos professores Alice Derbócio e Ricardo Gentil pelo incentivo e apoio. Agrotóxicos são produtos químicos aplicados no ambiente para controlar as espécies que causam danos às culturas agrícolas. No entanto, podem atingir espécies não-alvo ao serem carreados para os ecossistemas aquáticos e ainda causar sérios danos a saúde humana. Dentre os diversos agrotóxicos destaca-se o Vertimec ® , utilizado em várias culturas agrícolas, incluindo morango e batata, produtos que compõem a renda econômica de muitos produtores rurais. Porém, apesar de seu uso intenso, existe ainda uma carência de estudos sobre seus potenciais riscos a biota terrestre e aquática. Dentro desse contexto, procurou-se avaliar os efeitos da aplicação do Vertimec ® sobre o fitoplâncton, por meio de estudos laboratoriais (bioensaio unialgal com Pseudokirchneriella subcapitata) e "in situ" (composição e densidade, em mesocosmos) a partir da simulação da contaminação do solo com Vertimec ® e posterior carreamento ao corpo hídrico, utilizando a água do runoff em bioensaio unialgal; da adição da água do runoff em mesocosmos, em quatro tratamentos (controle, runoff contaminado, não contaminado e adição direta do contaminante), avaliando os efeitos na estrutura da comunidade e do bioensaio unialgal com Abamectina, principal princípio ativo do Vertimec ® . Os resultados obtidos demonstram que os efeitos do runoff sobre a densidade celular de P. subcapitata não ocorreram em função do produto aplicado e sim pela elevada turbidez das amostras. Nos testes com a água dos mesocosmos, os tratamentos que receberam o runoff estimularam o crescimento de P. subcapitata, indicando o efeito do aporte de nutrientes ao meio de cultura, enquanto menores densidades ocorreram no tratamento com adição direta de Vertimec ® , porém, ainda maiores em relação ao controle. Na análise da estrutura da comunidade de fitoplâncton nos mesocosmos, verificou-se alterações nas características físicas e químicas da água (pH, oxigênio dissolvido, turbidez, condutividade e nutrientes), caracterizando efeitos do runoff (com ou sem Vertimec ® ) ou da adição direta do contaminante, os quais implicaram em mudanças...

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Assessment of the environmental fate and effects of ivermectin in aquatic mesocosms

Cited by 115 publications

References 34 publications

Risks of agricultural pharmaceuticals in surface water systems and soils

Risks of agricultural pharmaceuticals in surface water systems and soils

Transport of oxytetracycline, chlortetracycline, and ivermectin in surface runoff from irrigated pasture

Efeitos do agrotóxico Vertimec no fitoplâncton: um estudo laboratorial e "in situ"

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