Assessment of the efficacy of Ankaferd blood stopper on the prevention of postoperative pericardial adhesions : cardiovascular topic

Abstract

SummaryObjectivesAnkaferd has been used as a blood-stopping agent and it may also have an anti-inflammatory effect. We investigated the efficacy of Ankaferd in preventing postoperative pericardial adhesions in an experimental rabbit model.MethodsSixteen New Zealand white rabbits were used and categorised into two groups: an Ankaferd and a control group. The Ankaferd group of rabbits was treated with a sponge impregnated with Ankaferd solution, which was applied over the abraded epicardium. A sponge impregnated with 0.9% isotonic NaCl solution was applied to the control group using the same protocol. Scores for adhesion and visibility of coronary vessels were graded by macroscopic examination, and pericardial tissues were analysed microscopically in terms of inflammation and fibrosis.ResultsIn the Ankaferd group, the adhesion scores were significantly higher than in the control group (p = 0.007). When the groups were compared according to the prevalence of fibrosis and degree of inflammation, the Ankaferd group was found to be statistically significantly different from the control group in terms of prevalence of fibrosis (p = 0.028).ConclusionTopical application of Ankaferd to prevent postoperative pericardial adhesions increased adhesion and fibrosis scores.

The effect of ankaferd blood stopper on epidural fibrosis after laminectomy in rats: an experimental study

“…According to several previous studies, although the mechanism of adhesion formation is not fully understood, fibroblast activity and inflammatory responses are believed to be important in the pathogenesis of adhesion formation (23). The most significant histopathological finding observed in the surgical field is excessive fibroblast migration, which causes scarring and fibrosis (11,16).…”

“…Conversely, Behcet et al showed that ABS was not efficient in reducing postoperative intra-abdominal adhesions, with the degree of fibrosis and fibroblast amount increasing with the dosage of ABS (1). Nazli et al showed that topical application of Ankaferd could increase pericardial adhesion after abrasive injury of the epicardial surface in an experimental rabbit model (23).…”

Haemostatic Effects of Topical Ankaferd Blood Stopper® On Bleeding Time in A Rat Abdominal Aortic Bleeding Model

“…A post-mortem histopathological examination revealed a hepatic venous outfl ow obstruction, indicating a potential life-threatening effect of even a small amount of the drug. Nazlı et al applied ABS-soaked sponges over the abraded epicardium of 16 white rabbits to test whether ABS prevents post-operative pericardial adhesions (15) . The authors reported that ABS did not prevent the adhesions but caused the formation of pericardial adhesions and fi brosis.…”

The effects of ankaferd blood stopper and microporous polysaccharide hemospheres on epidural fibrosis in rat laminectomy model

“…Acta Cirúrgica Brasileira -Vol. 30 (12) experimental peripheral nerve injuries model, and it was showed that the stereological analysis techniques can supply correct and trustworthy estimates of fibroblast count and epidural fibrosis [15][16] .…”

“…İlaç AS, Istanbul, Turkey) is a folkloric medicinal plant extract product, which has historically been used in Turkish practical medicine as a hemostatic agent [26][27][28][29][30] . It is a standardized mixture of the agent containing various ratios of five herbal extracts: Thymus vulgaris, Glycyrrhiza Glabra, Vitis Vinifera, Alpinia Officinarum, and Urtica Dioica.…”