Assessment of the Efficacy and Safety of Nimesulide vs Naproxen in Paediatric Patients with Respiratory Tract Infections

Rodriguez, L. E. Salmòn; Viveros, H. A. Arista; Lujan, Marla E.; Maciel, Rui M. B.; Trujillo, Christian; López, Eugenio Mercado

doi:10.2165/00003495-199300461-00058

Cited by 7 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At least equivalent efficacy of nimesulide and naproxen observed in the current study is in keeping with findings in other indications including acute upper respiratory tract infection, 23 sports injury, 24 tendinitis and bursitis, 25 advanced cancer pain 26 and post surgery. 27 The current study showed similar overall tolerability between the two agents, although within the observed variability there was a trend for lower frequency of gastrointestinal side-effects with nimesulide (Mann-Whitney estimator = 0.5206).…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

“…The current study showed similar overall tolerability between the two agents, although within the observed variability there was a trend for lower frequency of gastrointestinal side‐effects with nimesulide (Mann‐Whitney estimator = 0.5206). The latter is in keeping with several reports of superior tolerability of nimesulide compared with naproxen, 17,23–25 in keeping with its more selective mode of action. The current study was primarily designed to examine efficacy rather than tolerability and safety, and because of the relatively high frequency of ad verse events certainly unrelated to study medication (about 50%) in a population of patients with OA, it may be difficult to show a difference in overall tolerability unless a trial is specifically designed to address this issue.…”

Section: Discussionsupporting

confidence: 87%

See 2 more Smart Citations

Double‐blind Study Comparing the Long‐term Efficacy of the Cox‐2 Inhibitor Nimesulide and Naproxen in Patients With Osteoarthritis

Kriegel¹,

Korff

Ehrlich³

et al. 2001

Int J Clinical Practice

View full text Add to dashboard Cite

SUMMARYThis double‐blind one‐year study compares the long‐term efficacy and safety of nimesulide with naproxen in patients with osteoarthritis (OA) of the knee or hip. Patients were randomised to nimesulide 100 mg twice daily (n=183) or naproxen 250 mg morning, 500 mg evening (n=187). The primary efficacy variable was change in pain intensity (WOMAC A scale) at 6 months. Nimesulide tablets showed at least equivalent efficacy to naproxen tablets in reducing pain intensity at 6 and 12 months (nimesulide ‐22.5% at 6 and 12 months; naproxen ‐22.4% at 6 months, ‐19.9% at 12 months; non‐inferiority proven). At 6 months the investigator assessed efficacy as ‘good’ or ‘excellent’ in 59.3% of nimesulide and 56.4% of naproxen‐treated patients, with corresponding values for patient assessment of 57% and 52.7%. Both treatments were well tolerated, with fewer related gastrointestinal adverse events reported with nimesulide (77 cases, 47.5%) than with naproxen (96 cases, 54.5%). This study shows nimesulide to be as effective as naproxen in the long‐term treatment of OA and to be associated with fewer gastrointestinal side‐effects.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Double‐blind Study Comparing the Long‐term Efficacy of the Cox‐2 Inhibitor Nimesulide and Naproxen in Patients With Osteoarthritis

Kriegel¹,

Korff

Ehrlich³

et al. 2001

Int J Clinical Practice

View full text Add to dashboard Cite

show abstract

“…11 Another study investigated the effect of naproxen (dosing according to age) compared with nimesulide (another NSAID) on fever and pain during an 8-day period in children with acute pharyngotonsillitis. 12 This study found nimesulide to be superior to naproxen on both outcomes but results regarding the absolute effects of naproxen were not reported, as no placebo group was included.…”

Section: Efficacy Of Naproxen On Fever and Acute Painmentioning

confidence: 84%

“…A randomized, controlled trial investigating the effects of naproxen (21 mg/kg/day in three doses) vs. placebo on fever and ear pain in children with acute otitis media did not find a significant difference in days with fever or days with pain between the two groups (mean days with fever/pain <1) 11 . Another study investigated the effect of naproxen (dosing according to age) compared with nimesulide (another NSAID) on fever and pain during an 8-day period in children with acute pharyngotonsillitis 12 . This study found nimesulide to be superior to naproxen on both outcomes but results regarding the absolute effects of naproxen were not reported, as no placebo group was included.…”

Section: Resultsmentioning

confidence: 99%

Safety and efficacy of naproxen for fever and acute pain in preschool children: a systematic review

Mathiesen

Jørgensen

2022

Adverse Drug Reaction Bulletin

View full text Add to dashboard Cite

Preschool children may require acute pain and fever management beyond the effects of paracetamol. Ibuprofen, an NSAID, is the first-choice analgesic add-on in children, as its effects and safety profile are well-known in children. In some countries, however, ibuprofen in oral solution is not available; thus, naproxen (another NSAID) could be an alternative. In this systematic review, we evaluated the effect of naproxen on fever and acute pain as well as related adverse events in preschool children. Although the evidence was limited, naproxen appears to be well tolerated and efficient in treating acute pain and fever in preschool children.

show abstract

Clinical applications of nimesulide in pain, arthritic conditions and fever

Bianchi

Ehrlich

Facchinetti³

et al. 2005

Nimesulide — Actions and Uses

View full text Add to dashboard Cite

Assessment of the Efficacy and Safety of Nimesulide vs Naproxen in Paediatric Patients with Respiratory Tract Infections

Cited by 7 publications

References 4 publications

Double‐blind Study Comparing the Long‐term Efficacy of the Cox‐2 Inhibitor Nimesulide and Naproxen in Patients With Osteoarthritis

Double‐blind Study Comparing the Long‐term Efficacy of the Cox‐2 Inhibitor Nimesulide and Naproxen in Patients With Osteoarthritis

Safety and efficacy of naproxen for fever and acute pain in preschool children: a systematic review

Clinical applications of nimesulide in pain, arthritic conditions and fever

Contact Info

Product

Resources

About