Assessment of the Effects of Flurazepam and Nitrazepam on Visuo‐motor Performance Using an Automated Assessment Technique

Sambrooks, Jean E.; MacGulloch, M. J.; Birtles, C.J.; Smallman, Clive

doi:10.1111/j.1600-0447.1972.tb04387.x

Cited by 13 publications

(7 citation statements)

References 12 publications

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“…Clobazam is distinguished from the two internal controls by producing a mean response latency shorter than placebo. The longer response latencies found with amylobarbitone sodium 100 mg and nitrazepam 5 mg are in accord with previous acute dose work on the two compounds using similar measures (Malpas & Joyce, 1969;Sambrooks et al, 1972;Hindmarch, 1975).…”

Section: Resultssupporting

confidence: 89%

Some aspects of the effects of clobazam on human psychomotor performance.

Hindmarch¹

1979

Brit J Clinical Pharma

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1Three studies are described, the first being a comparison of the effects of acute night-time doses of clobazam 20 mg, amylobarbitone sodium 100 mg, nitrazepam 5 mg and placebo, on choice reaction time, critical flicker fusion (CFF) and stabilometer performance. Clobazam improved early morning performance on a choice reaction test, in contrast to the other two active drugs. 2 Repeated doses of clobazam 10 mg three times daily, chlordiazepoxide 10 mg three times daily and diazepam 5 mg three times daily were given for 5 days. Again clobazam did not produce any impairment of psychomotor performance, and noticeably increased CFF thresholds. 3 The effects of an acute night-time dose of clobazam 20 mg on psychomotor performance the morning after night-time medication were correlated with the neuroticism scores (on the EPI) of the subjects. Clobazam exerts a differential effect on psychomotor performance dependent on the basic personality trait. 4 Clobazam seems to differ significantly from the 1,4-benzodiazepines in that, although it reduces anxiety, it does so without any apparent impairment of psychomotor performance.

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Section: Resultssupporting

confidence: 89%

Some aspects of the effects of clobazam on human psychomotor performance.

Hindmarch¹

1979

Brit J Clinical Pharma

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“…Of the battery of seven tests used, only the symbol copying test and a digit symbol substitution test showed any statistically significant effect; for reaction time, tapping rate, a cancellation task and card sorting, the performance tended to be worse with flurazepam but this did not reach statistical significance. Measuring the effects of flurazepam on performance on a visuomotor task over a much shorter time scale in normal female volunteers, Sambrooks, MacCulloch, Birtles & Smallman (1972) reported that flurazepam (15 mg) produced only slight impairment in performance which was less than that following nitrazepam (5 mg).…”

Section: Introductionmentioning

confidence: 99%

A clinical and psychometric evaluation of flurazepam.

Salkind¹,

Silverstone²

1975

Brit J Clinical Pharma

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“…Sambrooks et al (17) have shown that flurazepam does not produce any significant decrement in visuo-motor performance when tested 1 h after inges tion of the drug, whereas nitrazepam does. This suggests that flurazepam may be preferable from the point of view of its effect, for example, on a patient's ability to drive a car.…”

Section: Discussionmentioning

confidence: 99%

Effect of Flurazepam on Sleep in the Laboratory

Johns¹,

Masterton²

1974

Pharmacology

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A new hypnotic drug, flurazepam, was given to six healthy young men in a blind trial involving sleep on four consecutive nights in the laboratory. Continuous recordings of the electro-encephalogram, electro-oculogram and electrical resistance of palmar skin made throughout the night enabled sleep to be analyzed objectively in terms of the usual stages. Sleep on the third night, when flurazepam 15 mg was taken, was compared with that on the second and fourth nights, when a placebo was taken. Flurazepam permitted sleep which was objectively better and subjectively as good as the best sleep without the drug. There was no inhibition either of REM-sleep or of δ-wave sleep as occurs with many other hypnotics.

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Assessment of the Effects of Flurazepam and Nitrazepam on Visuo‐motor Performance Using an Automated Assessment Technique

Cited by 13 publications

References 12 publications

Some aspects of the effects of clobazam on human psychomotor performance.

Some aspects of the effects of clobazam on human psychomotor performance.

A clinical and psychometric evaluation of flurazepam.

Effect of Flurazepam on Sleep in the Laboratory

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