Assessment of the Effect of Perioperative Venous Lidocaine on the Intensity of Pain and IL-6 Concentration After Laparoscopic Gastroplasty

Oliveira, Clair Motos de; Coelho, Lais Maria Gaspar; Valadão, José Aparecido; Moura, Ed Carlos Rey; Silva, Antônio Augusto Moura da; Lima, Roclides Castro de; Brunialti, Milena Karina Coló; Salomão, Reinaldo; Leal, Plínio da Cunha; Sakata, Rioko Kimiko

doi:10.1007/s11695-020-04748-1

Cited by 9 publications

(8 citation statements)

References 39 publications

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“…In Group HL, the levels of plasma IL-6, IL-10, and TNF-α were lower than those in Groups LL or C at various time points, which demonstrated that a relatively high-dose of lidocaine could alleviate the inflammatory response induced by surgical procedures, which was consistent with previous studies. 12,25,26 However, de Oliveira et al 9 reached an opposing conclusion, whereby intravenous lidocaine failed to interfere with the production of IL-6, an outcome that was similar to another study, 27 in which blood samples were tested preoperatively, and at 1 hour and 5 hours after the start of surgery, and at 24 hours postoperatively. In this study,…”

Section: Discussionmentioning

confidence: 66%

“…[5][6][7] Lidocaine, an adjuvant analgesic, is widely used in nerve block and intravenous infusion for its analgesic, antiarrhythmic, or anti-inflammatory effects. 8 de Oliveira et al 9 reported that systemic lidocaine with a bolus of 1.5 mg/kg followed by infusion at 2.0 mg/kg/hour effectively reduced the need for opioids and the intensity of postoperative pain prolonging the time to the first request for morphine. Ho et al 10 reported prolonging the duration of lidocaine infusion to 48 hours after surgery, and revealed that lidocaine administration reduced opioid consumption by up to 40% from 24 to 72 hours postoperatively.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, there were no patients lost to follow-up. Furthermore, the lidocaine regimen we had chosen was based on previous studies, 8,9 and we discontinued infusion at the end of the surgery; thus, the total lidocaine administration in our study was relatively small. In addition, Carabalona et al 40 monitored serum concentrations of lidocaine following a 1.5 mg/kg bolus and continued infusion at 2.0 mg/kg/hour.…”

mentioning

confidence: 99%

“…Firstly, we did not directly measure the plasma concentrations of lidocaine. The lidocaine dose in our study was based on those used in previous studies 8,9 and on results of relevant meta-analysis. 41 However, all patients were continuously monitored for 24 hours after surgery and none showed evidence of lidocaine-related toxicity.…”

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confidence: 99%

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Effects of Systemic Lidocaine on Postoperative Recovery Quality and Immune Function in Patients Undergoing Laparoscopic Radical Gastrectomy

Lv¹,

Li²,

Guo³

et al. 2021

DDDT

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Objective This study aimed to explore the effects of lidocaine on postoperative quality of recovery (QoR) and immune function in patients undergoing laparoscopic radical gastrectomy. Methods In total, 135 patients were enrolled and were equally randomized to receive low-dose lidocaine (Group LL: 1.5 mg/kg bolus followed by an infusion at 1.0 mg/kg/hour) or high-dose lidocaine (Group HL: 1.5 mg/kg bolus followed by an infusion at 2.0 mg/kg/hour) or Controls (Group C: received a volume-matched normal saline at the same rate). The primary outcome was a QoR-40 score on postoperative day (POD) 1. Secondary outcomes were a QoR-40 score on POD 3, levels of inflammatory factors (IL-6, IL-10, TNF-α) and CD4 + T cells, CD8 + T cells proportions, and CD4 + /CD8 + cell ratios and postoperative recovery of bowel function. Results There were no statistically significant differences in patient characteristics at baseline. The total QoR-40 scores on POD 1 in Group HL (171.4±3.89) were higher than those in Group LL (166.20±4.05) and in Group C (163.40±4.38) (adjusted P <0.001). Differences in the dimension scores of QoR-40 for pain, physical comfort, and emotional state were significant across the three groups. Lidocaine administration significantly reduced the release of IL-6, IL-10, TNF-α, and attenuated immune changes induced by trauma. Kaplan–Meier curves showed that the median time to the first exhaust and defecation were shorter in the Group HL than in Groups LL and C (1.55 days vs 2.4 days vs 2.6 days, log rank P <0.0001; and 2.86 days vs 3.22 days vs 3.46 days, log rank P =0.002, respectively). Additionally, patients in lidocaine groups required less remifentanil consumption and experienced lower pain intensity, compared with the control group. Conclusion Systemic lidocaine improved postoperative recovery, alleviated inflammation and immunosuppression, and accelerated the return of bowel function, and is thus, worthy of clinical application. Clinical Trials Registration ChiCTR2000028934.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of Systemic Lidocaine on Postoperative Recovery Quality and Immune Function in Patients Undergoing Laparoscopic Radical Gastrectomy

Lv¹,

Li²,

Guo³

et al. 2021

DDDT

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“…Dexmedetomidine and lidocaine are common adjuvant medicines anesthetics during operation for the sedative, analgesic and neuroprotective properties. Besides, some studies have proved that both are effective in relieving postoperative pain in adults and children [34][35][36][37][38]. However, there are currently only few studies comparing the effects of both medicines on postoperative analgesia, and the conclusions are inconsistent [39,40].…”

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confidence: 99%

Dexmedetomidine Versus Lidocaine for Postoperative Analgesia in Pediatric Patients Undergoing Craniotomy: a Protocol for a Prospective, Randomized, Double-blinded, Placebo-controlled Trial

Zhang

Bao

Chi

et al. 2021

Preprint

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Background: Postoperative pain is a common problem that occurs in pediatric patients following neurosurgery which may lead to severe complications. Dexmedetomidine is a commonly used adjuvant medicine in craniotomy owing to its sedative, amnestic, analgesic, and neuroprotective properties. Besides, studies suggest that lidocaine has similar effects on sedation, analgesia, and neuroprotection. Both two adjuvants can reduce postoperative pain after neurosurgery in adults. However, it is still unknown whether dexmedetomidine or lidocaine can reduce postoperative pain in children undergoing craniotomy and if yes, which is a better medicine choice. Therefore, we aimed to compare the effect of dexmedetomidine vs. lidocaine on postoperative pain in pediatric patients after craniotomy. Methods/design: We will perform a randomized (1:1:1), double-blind, placebo-controlled, single-center trial. Children aged 1–12 years scheduled for craniotomy will be eligible for inclusion. The 255 recruited participants will be stratified by age in two strata (1–6 years and 7–12 years), and then each stratum will be equally randomized to three groups: Group D (infusion of dexmedetomidine [intervention group]), Group L (infusion of lidocaine [intervention group]), and Group C (infusion of normal saline [control group]). Patients will be followed-up at 1 h, 2 h, 4 h, 24 h, and 48 h after surgery. The primary outcome will be total sufentanil consumption within 24 h after surgery.Discussion: In this clinical trial, we expect to clarify and compare the postoperative analgesic effect of dexmedetomidine vs. lidocaine infusion on pediatric patients undergoing craniotomy. We believe that the results of this trial will provide more choices for postoperative analgesia for the pediatric population.Trial registration: Chinese ClinicalTrials.gov Identifier: ChiCTR1800019411. Registered 10 November 2018. Registered with the name of “A randomized double-blind controlled trial for low-dose dexmedetomidine and lidocaine in the treatment of post-craniotomy pain in children” URL: http://www.chictr.org.cn/showproj.aspx?proj=32822

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Efficacy of intraoperative intravenous lidocaine for postoperative analgesia following bariatric surgery: a meta-analysis of randomized controlled studies

Hung

Chang

Chen

et al. 2022

Surgery for Obesity and Related Diseases

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Assessment of the Effect of Perioperative Venous Lidocaine on the Intensity of Pain and IL-6 Concentration After Laparoscopic Gastroplasty

Cited by 9 publications

References 39 publications

Effects of Systemic Lidocaine on Postoperative Recovery Quality and Immune Function in Patients Undergoing Laparoscopic Radical Gastrectomy

Effects of Systemic Lidocaine on Postoperative Recovery Quality and Immune Function in Patients Undergoing Laparoscopic Radical Gastrectomy

Dexmedetomidine Versus Lidocaine for Postoperative Analgesia in Pediatric Patients Undergoing Craniotomy: a Protocol for a Prospective, Randomized, Double-blinded, Placebo-controlled Trial

Efficacy of intraoperative intravenous lidocaine for postoperative analgesia following bariatric surgery: a meta-analysis of randomized controlled studies

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