Assessment of the effect of post-natal lead exposure on the hippocampus of developing wistar rats

Olatomide, Oluwasegun Davis; Adebisi, Samuel Sunday; Musa, Sunday Abraham

doi:10.1016/j.ibror.2019.09.063

Cited by 2 publications

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“…Metal toxicity causes oxidative stress, impairment in nervous system functions, and changes in glucose and calcium metabolism (Shinkai & Kaji, 2012). In addition, metals may produce adverse effects in many different organs or tissues such as the brain, blood, kidney, liver and elements of the reproductive system (Baty et al., 2020; Case rta et al., 2013; Olatomide et al., 2019). In this context, lead is one of the principal heavy metals threatening human health (Ashafaq et al., 2016; Matović et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

The protective effects of pomegranate juice on lead acetate‐induced neurotoxicity in the male rat: A histomorphometric and biochemical study

Annaç

Uçkun

Özkaya

et al. 2021

Journal of Food Biochemistry

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The purpose of this study was to investigate the potential side-effects of lead acetate (LA), which is toxic to the nerves, blood and muscles, in the rat brain. The neuroprotective effects of pomegranate juice (PJ) against LA exposure were also observed. The experiment involved 28 male Wistar albino rats aged 12 weeks. These were divided into four groups: Control, PJ, LA and LA+PJ. Stereological techniques were employed to determine hippocampal volume in each rat brain. Biochemical investigations and histopathological examinations were also performed. Analysis demonstrated a significant decrease in hippocampal volume in the LA group compared to the control group (p < .05). The stereology results also indicated that PJ has protective effects when compared with the LA and LA+PJ groups. A significant increase was also determined in malondialdehyde (MDA) levels and glutathione S-transferase (GST) activity in the LA group compared to the control group, in contrast to glutathione (GSH) levels and carboxylesterase (CaE) and acetylcholinesterase (AchE) activities. MDA and GST activity decreased significantly in the LA+PJ group compared to the LA group in contrast to GSH levels and CaE and AchE activities. Histopathological examination revealed a number of degenerative changes in the LA group. Exposure to LA adversely affects the hippocampus on the male rat brain. It might also be suggested that PJ may ameliorate these deleterious effects.

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Section: Discussionmentioning

confidence: 99%

The protective effects of pomegranate juice on lead acetate‐induced neurotoxicity in the male rat: A histomorphometric and biochemical study

Annaç

Uçkun

Özkaya

et al. 2021

Journal of Food Biochemistry

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“…Similarly, Abubakar [52] reported that mercury intoxication reduces the concentration of copper in the brain. Zucconi et al, [53] in the same vein reported that decrease in copper concentration in the brain can interfere with the modulatory role of dopamine receptors and consequently lead to motor function deficits similar to what is seen in patients of Parkinsonism. The poor result of the hanging wire test presented in Table 4 reveal that the rats had muscle weakness and so could not hold up long enough on the hanging wire.…”

Section: Discussionmentioning

confidence: 87%

Comparing the Neuroprotective Effects of Aqueous and Methanolic Extracts of Vernonia Amygdalina on the Cerebellum of Adult Male Wistar Rats

Aguwa

Okeke

et al. 2020

Int. Ann. Sci.

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The solvent of extraction determines the type and amount of phytochemicals extractible from a plant material. Reports have shown that numerous African herbs are rich is potent phytochemicals which have been used in folkloric and orthodox medicine in the prevention and treatment of ailments. This research is geared towards comparing the neuroprotective potency of the aqueous and methanolic extracts of Vernonia amygdalina on the cerebellum of mercury chloride intoxicated Wistar rats. Thirty adult male Wistar rats were divided into 6 groups of 5 rats each. Group A was the negative control and had food and water only. Group B was the positive control and was exposed to mercury chloride without treatment. Groups C1 and C2 received 200mg/kg bw of aqueous and methanolic extracts respectively while groups D1 and D2 received 400mg/kg bw of aqueous and methanolic extracts of Vernonia amygdalina respectively. Result of phytochemical analysis shows that water extracted more flavonoids while methanol extracted more phenols. The results of antioxidant studies show that the methanolic extract conferred more protection against oxidative stress than the aqueous extract. Histological results show that aqueous extract conferred more protection than the methanolic extract. We therefore conclude from our report that both the aqueous and methanolic extracts of Vernonia amygdalina confer neuroprotection on the cerebellum of Wistar rats.

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Assessment of the effect of post-natal lead exposure on the hippocampus of developing wistar rats

Cited by 2 publications

References 0 publications

The protective effects of pomegranate juice on lead acetate‐induced neurotoxicity in the male rat: A histomorphometric and biochemical study

The protective effects of pomegranate juice on lead acetate‐induced neurotoxicity in the male rat: A histomorphometric and biochemical study

Comparing the Neuroprotective Effects of Aqueous and Methanolic Extracts of Vernonia Amygdalina on the Cerebellum of Adult Male Wistar Rats

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