Assessment of the effect of external counterpulsation on myocardial adaptive arteriogenesis by invasive functional measurements — design of the arteriogenesis network trial 2

Pagonas, Nikolaos; Utz, Wolfgang; Schulz‐Menger, Jeanette; Busjahn, Andreas; Monti, Jan; Thierfelder, Ludwig; Dietz, Rainer; Klauß, Volker; Groß, Michael; Buschmann, Ivo; Buschmann, Eva-Elina

doi:10.1016/j.ijcard.2009.05.050

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…vi. Right heart vs. left heart endothelium, this study suggested that the right heart endothelium responded rapidly, to shear stress stimuli, compared to the left heart endothelium, which is most frequently, stimulated with devices like IABP and EECP, known for tolerance and long with long term effectiveness respectively (Pagonas, 2010). We found that the PA endothelium was hypersensitive; a few minutes of intrapulmonary pulsations were more than sufficient to drop systemic and pulmonary p r e s s u r e s .…”

Section: Commentmentioning

confidence: 92%

“Flow and Rate”: Concept and Clinical Applications of a New Hemodynamic Theory

Nour¹

2012

Biophysics

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Section: Commentmentioning

confidence: 92%

“Flow and Rate”: Concept and Clinical Applications of a New Hemodynamic Theory

Nour¹

2012

Biophysics

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“…A number of other methods have been studied as mediators of supporting collaterals, including external counterpulsation. This is a technique which titrates pressure in the extremities in a synchronized manner and has been shown to support collaterals in the coronary circulation [84]. In the cerebral circulation, this technique was demonstrated to elevate arterial blood flow velocities as measured by transcranial Doppler ultrasonography [85].…”

Section: Role Of Collateral Circulation In Reperfusion Therapymentioning

confidence: 99%

Ischemia-Reperfusion Injury in Stroke

2012

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Despite ongoing advances in stroke imaging and treatment, ischemic and hemorrhagic stroke continue to debilitate patients with devastating outcomes at both the personal and societal levels. While the ultimate goal of therapy in ischemic stroke is geared towards restoration of blood flow, even when mitigation of initial tissue hypoxia is successful, exacerbation of tissue injury may occur in the form of cell death, or alternatively, hemorrhagic transformation of reperfused tissue. Animal models have extensively demonstrated the concept of reperfusion injury at the molecular and cellular levels, yet no study has quantified this effect in stroke patients. These preclinical models have also demonstrated the success of a wide array of neuroprotective strategies at lessening the deleterious effects of reperfusion injury. Serial multimodal imaging may provide a framework for developing therapies for reperfusion injury.

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“…The here presented method significantly improves inter--individual reproducibility of collateral conduction measurements, even in small animals like mice. It is therefore suitable for the demands of drug development strategies for peripheral-, cardiac-, and cerebral arterial occlusive diseases [21,22].…”

Section: Discussionmentioning

confidence: 99%