Assessment of the effect of vincristine on the biodistribution of 99Tcm-labelled glucoheptonic acid in female Balb/c mice

Abstract

There is evidence that the biodistribution and the pharmacokinetics of 99Tcm radiopharmaceuticals can be modified by some drugs, pathological states, irradiation and surgical procedures. Vincristine have been widely used in various chemotherapeutic protocols in oncology. We are trying to develop an animal model to assess the toxicology in different organs of compounds used as therapeutic drugs. We have studied the effect of vincristine on the distribution of 99Tcm-glucoheptonic acid (99Tcm-GHA) in female mice. After the last dose of vincristine, 99Tcm-GHA (7.4 MBq) was injected, the animals sacrificed and the percentage of radioactivity determined in the isolated organs. The percentage of activity was significantly decreased in the uterus, ovary, spleen, thymus, lymph nodes (inguinal and mesenteric), kidney and heart, but was not significantly altered in the lung, liver, pancreas, stomach, thyroid, brain and bone. Our results can be explained by the metabolic, toxic, therapeutic and immunosuppressive actions of this chemotherapeutic drug.

Biodistribution of the radiophamarceutical sodium pertechnetate (Na99mTcO4) after massive small bowel resection in rats

“…The labelling capacity of these isotopes for the plasmatic proteins is well known, and their bioavailability and pharmacokinetics can be modifi ed by drugs and diseases 1,2 . Among the most useful artifi cial radioisotopes, technetium-99m, in the chemical form of sodium pertechnetate (Na 99m Tc0 4 ), is the most important.…”

Efeito de um extrato de Hipérico (Hypericum perforatum) na marcação in vitro de elementos sangüíneos com tecnécio-99m e na biodisponibilidade do radiofármaco pertecnetato de sódio em ratos Wistar

“…O radiofármaco pertecnetato de sódio é distribuído através dos líquidos vasculares e intersticiais e apresenta normalmente uma captação preferencial na tiróide, o estômago, trato intestinal, e glândulas salivares 14 . Vários fatores, como a terapia com drogas, a terapia com radiação, processos cirúrgicos, condições de dieta, além de doenças podem afetar a biodistribuição dos diferentes radiofármacos 9,[16][17][18][19] . Esses fatores levam a uma repetição do exame, resultando numa irradiação desnecessária ao paciente.…”

Effect of mitomycin‐C on the bioavailability of the radiopharmaceutical 99mtechnetium–phytic acid in mice: a model to evaluate the toxicological effect of a chemical drug

“…However, these alterations in biodistribution may be related to chemotherapeutic drug interaction. 6,10 There is considerable evidence that the pharmacokinetics of radiopharmaceuticals may be altered by a variety of drugs, disease states and surgical procedures. If unknown, such factors may lead to poor organ visualization, a requirement to repeat the procedure resulting in unnecessary irradiation of organs or even misdiagnosis.…”