Assessment of the effect of sachet formulation of almond (Amygdalus dulcis L.) on diarrhea prominent irritable bowel syndrome (IBS-D) symptoms: A clinical trial

Darvishmoghadam, Sodaif; Ansari, Mehdi; Ahmadipour, Habibeh; Azimipour, Mahnaz; Esmaeilzade, Maria; Zahedi, Mohammad Javad; Abbasi, Mehdi; Ahmadi, Bijan; Asadi, Afshin; Sharififar, Fariba

doi:10.1016/j.ctim.2019.07.001

Cited by 10 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Each intervention arm of the trial was entered into the meta-analysis separately in comparison to the control arm. Finally, one trial did not report any outcome data in a form that could be meta-analysed [ 22 ]. The authors were contacted but supplied no further data.…”

Section: Resultsmentioning

confidence: 99%

“…Eight RCTs measured outcomes related to faecal microbiota including relative abundance at the phyla and genus levels, and metrics for alpha and beta diversity [ 16 , 17 , 18 , 19 , 20 , 21 , 27 ]. Three RCTs reported stool frequency [ 18 , 20 , 22 ] and two RCTs reported gut symptoms [ 18 , 22 ]. No RCTs measured gut transit time or stool form.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies, including four RCTs, measured stool frequency [ 18 , 20 , 22 ]. One study reported stool frequency on a three-point scale (mild, moderate, severe) with no details on cut-offs used for each category [ 22 ]. Corresponding authors were contacted but data was not obtained and so this study was not included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies evaluated gastrointestinal symptoms [ 18 , 22 ], however these were not meta-analysed due to differences in measurement method and outcome reporting. The first study measured the impact of almonds on gastrointestinal symptoms in healthy adults using the gastrointestinal symptoms ratings scale (GSRS).…”

Section: Resultsmentioning

confidence: 99%

“…The results of subsequent randomised controlled trials (RCTs) have been conflicting, with some reporting an increase [ 16 ], decrease [ 17 ] or no effect [ 18 , 19 , 20 , 21 ] of nut consumption on faecal bifidobacteria . In addition, few studies have investigated the impact of nut consumption on gut function or symptoms [ 18 , 20 , 22 ]. Therefore, the aim of this study was to investigate the impact of nut consumption on the gut microbiota, gut function, and gut symptoms in healthy adults via a systematic review and meta-analysis of RCTs.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Nuts and their Effect on Gut Microbiota, Gut Function and Symptoms in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

et al. 2020

View full text Add to dashboard Cite

Nuts contain fibre, unsaturated fatty acids and polyphenols that may impact the composition of the gut microbiota and overall gut health. This study aimed to assess the impact of nuts on gut microbiota, gut function and gut symptoms via a systematic review and meta-analysis of randomised controlled trials (RCTs) in healthy adults. Eligible RCTs were identified by systematic searches of five electronic databases, hand searching of conference abstracts, clinical trials databases, back-searching reference lists and contact with key stakeholders. Eligible studies were RCTs administering tree nuts or peanuts in comparison to control, measuring any outcome related to faecal microbiota, function or symptoms. Two reviewers independently screened papers, performed data extraction and risk of bias assessment. Outcome data were synthesised as weighted mean difference (WMD) or standardised mean difference (SMD) using a random effects model. This review was registered on PROSPERO (CRD42019138169). Eight studies reporting nine RCTs were included, investigating almonds (n = 5), walnuts (n = 3) and pistachios (n = 1). Nut consumption significantly increased Clostridium (SMD: 0.40; 95% CI, 0.10, 0.71; p = 0.01), Dialister (SMD: 0.44; 95% CI, 0.13, 0.75; p = 0.005), Lachnospira (SMD: 0.33; 95% CI, 0.02, 0.64; p = 0.03) and Roseburia (SMD: 0.36; 95% CI, 0.10, 0.62; p = 0.006), and significantly decreased Parabacteroides (SMD: −0.31; 95% CI, −0.62, −0.00; p = 0.05). There was no effect of nuts on bacterial phyla, diversity or stool output. Further parallel design RCTs, powered to detect changes in faecal microbiota and incorporating functional and clinical outcomes, are needed.

show abstract

Section: Resultsmentioning

confidence: 99%