Assessment of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis

Abstract

BackgroundRegenerative medicine using Mesenchymal Stem Cells (MSC) alone or combined with Plasma Rich in Growth Factors (PRGF) is a rapidly growing area of clinical research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify and quantify the efficacy of different therapeutic strategies for the treatment of OA in dogs including MSC associated to PRGF, but never with AD-MSC alone.The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA.ResultsTen lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved within the first three months post-treatment in the OA group, increasing 9% and 2.5% body weight, respectively, at day 30. After this, the effect seems to decrease reaching initial values.ConclusionIntraarticular ADMSC therapy objectively improved limb function in dogs with hip OA. The duration of maximal effect was less than 3 months.

Static Posturography: A New Perspective in the Assessment of Lameness in a Canine Model

“…Peak vertical force (PVF) and vertical impulse (VI) are two of the most common kinetic parameters used for lameness detection in dogs, horses and other domestic animal species [1]; these parameters are usually obtained using force [2] or pressure platforms [3–5]. …”

Biomechanic characteristics of gait of four breeds of dogs with different conformations at walk on a treadmill

“…To minimize this, some authors try to homogenize the animal groups using dogs of the same breed (Vilar et al 2014). If this is not possible, comparative studies with animals of different conformations necessarily require a res-caling, harmonization or normalization of methods.…”

Nutraceuticals in Arthritis

“…To achieve these goals, a variety of pharmaceuticals, nutraceuticals, diseasemodifying agents, stem cell therapy, and physical therapy with acupuncture can be used (Abadie et al, 2004;Dieppe and Lohmander, 2005;Martel-Pelletier et al, 2005;Mathews and Hunter, 2011;Panahifar et al, 2014;Vilar et al, 2014). To achieve these goals, a variety of pharmaceuticals, nutraceuticals, diseasemodifying agents, stem cell therapy, and physical therapy with acupuncture can be used (Abadie et al, 2004;Dieppe and Lohmander, 2005;Martel-Pelletier et al, 2005;Mathews and Hunter, 2011;Panahifar et al, 2014;Vilar et al, 2014).…”