Assessment of the dietary exposure to non-dioxin-like PCBs of the Italian general population

Fattore, Elena; Fanelli, Roberto; Dellatte, Elena; Turrini, Aida; Domenico, Alessandro Di

doi:10.1016/j.chemosphere.2007.12.040

Cited by 88 publications

(61 citation statements)

References 18 publications

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“…the Portuguese daily intake is around 4 ng kg À1 bw d À1 , which is lower than the limit set by (WHO, 1997). The values estimated in the present work are lower to the ones estimated in Germany (11.2 ng kg À1 bw d À1 ) (Fromme et al, 2009) and in Italy (11.2 ng kg À1 bw d À1 ) (Fattore et al, 2008), and closer the ones estimated in France (5.42 ng kg À1 bw d À1 ) (Sirot et al, 2012).…”

Section: P Flesus Physiological Conditionscontrasting

confidence: 54%

Organochlorine contaminants in different tissues from Platichthys flesus (Pisces, Pleuronectidea)

Baptista¹,

Pato²,

Duarte³

et al. 2013

Chemosphere

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h i g h l i g h t sPlatichthys flesus muscle, liver and gills were analysed for PCBs and HCB. P. flesus was analysed along its lifespan, liver presented the highest concentration. P. flesus HCB concentration increased in the 3 tissues along the species lifespan. P. flesus PCB concentration decreased in the 3 tissues along the species lifespan. P. flesus is considered safe for human intake, regarding PCBs and HCB. a r t i c l e i n f o t r a c tPolychlorinated biphenyls (PCBs) and hexachlorobenzene (HCB) are organic contaminants that tend to accumulate in fish. Estuaries are exposed to high anthropogenic activities, therefore tending to accumulate more contaminants than the adjacent coastal waters. Platichthys flesus, a fish with high economic value, was analysed for PCBs and HCB along its different age groups, in liver, gills, gonads and muscle. Younger fishes were caught in the estuary, whereas older fishes were caught in the adjacent coastal waters and acquired at Figueira da Foz Regional Office of Docapesca-Portos e Lotas, SA. Both contaminants concentrations follow the pattern: liver > gills > muscle. Hepatosomatic index had the lowest values in younger fishes and the highest values in older fishes. Condition factor values remain stable with age. Younger fishes had higher PCBs concentrations than the older fishes. In opposition HCB was only detected in fish from 3+ to 5+ and its concentration tended to increase with age. Overall P. flesus is considered safe for human intake.

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Section: P Flesus Physiological Conditionscontrasting

confidence: 54%

Organochlorine contaminants in different tissues from Platichthys flesus (Pisces, Pleuronectidea)

Baptista¹,

Pato²,

Duarte³

et al. 2013

Chemosphere

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“…We also considered the study of Arnich et al 48 that assessed the dietary intakes of six non-dioxin-like PCBs indicators in 2002--2006 in France (considering that food contamination and consumption are similar in France and Italy). Assuming that the three congeners represent about 70% of the dietary intake of the PCBs indicators, 32 the intakes are similar for women but differ slightly for children (our predicted intake is 60% superior of their intake). These results support the relevance of our approach to reconstruct accurately the exposure of a population and to fill in the data gaps on dietary intake for the last 15 years.…”

Section: -1979mentioning

confidence: 99%

“…As the transfer of PCB from air to vegetation and pasture is rapid, 31 the concentrations in air can be transposed into concentrations in food (step 3). 32 The daily intakes were then calculated given the food contamination and the dietary habits of the Italian population (step 4). 33 In the following, these time-variant intakes are qualified as initial intake.…”

Section: A Dynamic Exposure Model To Calculate Daily Intakesmentioning

confidence: 99%

Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women

Ulaszewska

Ciffroy

Tahraoui

et al. 2012

J Expo Sci Environ Epidemiol

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Polychlorinated biphenyls (PCBs) are persistent contaminants suspected to cause adverse health effects in humans. As PCBs levels in food have not been monitored frequently in the past, modeling approaches based on environmental data have been proposed to predict the human dietary intake. In this work, we propose to improve these approaches by taking into account internal levels of PCBs in humans. This methodology is based on the analysis of biomonitoring data using exposure and physiologically based pharmacokinetic (PBPK) modeling to determine the most probable scenario of exposure. Breast milk concentrations were measured in Italian women for PCB-138, PCB-153 and PCB-180. For each congener, three exposure scenarios were derived and a PBPK model was used to relate the lifetime exposure to the breast milk levels. For the three PCBs, we determined the most probable scenario of exposure. Our results support the adequacy of the exposure and the PBPK models for PCB-180 and PCB-153, whereas we observed discrepancies between the models and the biomonitoring data for PCB-138. Our intake estimates are in good agreement with previous exposure assessments based solely on food contamination demonstrating the relevance of our approach to reconstruct accurately the exposure and to fill in data gaps on exposure.

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“…Patterns of food consumption are also different in children and adolescents compared to adults; for instance, due to higher intake compared to adults, milk may be a particularly important source of exposure for children to dioxins and PCBs [27] and PBDE [2]. Moreover, children may be subject to higher exposure simply because they ingest more food in proportion to their body weight, a ratio that slowly decreases during adolescence to become more stable at approximately 20 years of age [28].…”

Section: Different Stages Of Lifementioning

confidence: 99%

Endocrine Disrupters and Food Safety

Mantovani¹

2015

TOBIOTJ

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The general population is constantly exposed to a mixture of endocrine disrupters (ED), mainly through the food chain.The dietary exposure pathways are diverse, since ED can: i) affect diet components most liable to environmental pollution (e.g., polychlorinated and polybrominated chemicals in lipid-rich foods); ii) be employed in food production (e.g., certain groups of agrochemicals); iii) be released from food contact materials or during food production processes (such as bisphenol A or phthalates); iv) last but not least, be naturally present in food: endocrineactive nutrients and bioactive substances, such as iodine and phytoestrogens, respectively, may elicit health risks when intakes are excessive. Main health concerns from dietary exposure to ED include the building-up of a pollutants body burden and the potential for additive, "cocktail" effects.The factors modulting exposure and susceptibility are considered, including different stages of life, the modulation of risks by dietary habits and the multiple, often inadequately understood, interactions between ED and food components.

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Assessment of the dietary exposure to non-dioxin-like PCBs of the Italian general population

Cited by 88 publications

References 18 publications

Organochlorine contaminants in different tissues from Platichthys flesus (Pisces, Pleuronectidea)

Organochlorine contaminants in different tissues from Platichthys flesus (Pisces, Pleuronectidea)

Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women

Endocrine Disrupters and Food Safety

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