Assessment of the cytotoxicity of a mineral trioxide aggregate‐based sealer with respect to macrophage activity

Braga, Julia Mourao; Oliveira, Ricardo Reis; Martins, Renata de Castro; Vieira, Leda Quércia; Sobrinho, Antônio Paulino Ribeiro

doi:10.1111/edt.12190

Cited by 23 publications

(24 citation statements)

References 42 publications

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“…The presence of resin in other sealers containing MTA, such as MTA Fillapex (Angelus Indústria de Produtos Odontológicos S/A, Londrina, PR, Brazil), reduced cell survival rates (Braga et al . , Mestieri et al . , Zhou et al .…”

Section: Introductionmentioning

confidence: 99%

“…The composition of endodontic sealers plays an important role in their biocompatibility. The presence of resin in other sealers containing MTA, such as MTA Fillapex (Angelus Ind ustria de Produtos Odontol ogicos S/A, Londrina, PR, Brazil), reduced cell survival rates (Braga et al 2015, Mestieri et al 2015, Zhou et al 2015, whilst Endoseal MTA (EndoSeal, Maruchi, Seoul, Korea), a new sealer without resin, had lower cell viability than ProRoot (PMTA; Dentsply, Tulsa, OK, USA) (Lim et al 2015). Although Endoseal MTA is another type of MTA-based root canal sealer, the composition and particle size of different MTAs are not the same.…”

Section: Introductionmentioning

confidence: 99%

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Biocompatibility of three new calcium silicate‐based endodontic sealers on human periodontal ligament stem cells

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatibility of three new calcium silicate‐based endodontic sealers on human periodontal ligament stem cells

et al. 2016

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“…Paste B includes silicon dioxide, titanium dioxide, and base resin (pentaerythritol, rosinate, and toluene sulphonamide), and 13.2% set MTA particles as filler. The working time is 23 min, with a complete set time of approximately 2 h. Several properties of this root canal sealer, such as flow and viscosity [10, 11], dimensional change [11], material porosity [12, 13], sealing ability [11], radiopacity, electrical conductivity [14], antibacterial effect [15], biocompatibility [16–20], cytotoxicity [19, 21–23], and genotoxicity [24, 25], have been investigated.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Chemical Study of Calcium Silicate-Containing and Epoxy Resin-Based Root Canal Sealers

Reszka¹,

Nowicka

Lipski

et al. 2016

BioMed Research International

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Objective. The present study assessed the chemical elements in two novel calcium silicate-containing root canal sealers, BioRoot RCS and Well-Root ST, compared to a calcium silicate-containing root canal sealer that has been on the market for several years, MTA Fillapex, and epoxy resin-based sealer AHPlus. Material and Methods. The sealers were mixed and manipulated according to the manufacturers' instructions. Twelve cylindrical molds (inner diameter 4 mm; height 3 mm) were placed on a glass petri dish and packed with the materials. The dish was transferred to an incubator. After 72 h the molds were examined by scanning electron microscopy and energy dispersive X-ray microanalysis. Results. BioRoot RCS and Well-Root ST had high peaks of calcium, zirconium, oxygen, carbon, silicon, and chlorine. Well-Root ST also had sodium, magnesium, aluminum, and titanium peaks. MTA Fillapex and AHPlus had carbon, oxygen, calcium, titanium, and bismuth peaks. A silicon peak was also observed for MTA Fillapex, and zirconium and tungsten peaks for AHPlus. Conclusion. BioRoot RSC had the highest degree of purity. The clinical implication of metals contained in the other sealers needs to be investigated.

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“…According to the manufacturers’, this MTA-based sealer creates integrated, excellent and perfect seal and provides high biological regeneration (21). However, more recent studies have shown conflicting results regarding this claim (21,22). …”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of the sealing ability of three newly developed root canal sealers: A bacterial microleakage study

Jafari¹,

Sobhani²,

Kafil³

et al. 2016

J Clin Exp Dent

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BackgroundThe purpose of this study was to compare the sealing ability of MTA Fillapex, Apatite Root Canal Sealer and AH26 sealers.Material and MethodsThe present in vitro study was carried out on 142 extracted single-rooted human mature teeth. The teeth were randomly divided into three experimental groups (n=44) and two control groups (n=5). Three root canal sealers were MTA Fillapex, Apatite Root Canal Sealer and AH26. The teeth in the control groups were either filled with no sealer or made completely impermeable. The root canals were prepared and obturated with gutta-percha and one of the sealers. The teeth were sterilized with ethylene oxide gas prior to the bacterial leakage assessment using Enterococcus faecalis. Leakage was evaluated every 24 hours for 90 days. Data were analyzed with descriptive statistical methods and chi-squared test. If the data were significant, a proper post hoc test was used. Statistical significance was set at P<0.05.ResultsThe positive control specimens exhibited total bacterial penetration whilst the negative control specimens showed no evidence of bacterial penetration. At the end of the study, the analysis of microleakage with chi-squared test showed no significant differences between the experimental groups (P<0.05). The results of chi-squared test analyzing the pair-wise differences between the groups considering the numerical values for leakage day indicated the lowest leakage with AH26 and the highest with Apatite root sealer.ConclusionsAccording to the results of the present study, sealing ability of AH26 was significantly higher than that of MTA Fillapex and Apatite Root Canal Sealer. Key words:Mineral Trioxide aggregate, root canal obturation, dental seal.

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Assessment of the cytotoxicity of a mineral trioxide aggregate‐based sealer with respect to macrophage activity

Abstract: Comparison of MTA and FLPX effects upon macrophages indicates that FLPX may impair macrophage activity and viability, while MTA seems to increase phagocytic activity.

Cited by 23 publications

References 42 publications

Biocompatibility of three new calcium silicate‐based endodontic sealers on human periodontal ligament stem cells

Biocompatibility of three new calcium silicate‐based endodontic sealers on human periodontal ligament stem cells

A Comparative Chemical Study of Calcium Silicate-Containing and Epoxy Resin-Based Root Canal Sealers

In vitro evaluation of the sealing ability of three newly developed root canal sealers: A bacterial microleakage study

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