Uganda experiences recurrent epidemics. However, policies enacted to prevent or prepare for future epidemics remain unclear. This paper reviews policies that are shaping responses to the Coronavirus disease (COVID-19) in Uganda. An integrative systematic review approach using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) was adopted. Databases including organizational websites, bibliographical databases, and newsletters were searched for records on policies addressing response to COVID-19. Quality appraisal was conducted using the von Wright’s logic of events framework and the AGREE II (Appraisal of Guidelines, Research and Evaluation) checklist. A descriptive qualitative narrative approach was used for data analysis. Fifteen papers are included in this review. Uganda’s preparedness to COVID-19 was initiated before the first case was identified on 21 March 2020. Most documents included in our final analysis were soft policy (nonstatutory) documents (n=10). MoH implemented four public orders: notification of COVID-19; prohibition of entry into Uganda; control of COVID-19; prevention of COVID-19; requirements and conditions of entry into Uganda. In addition, the office of the president implemented three directives as of 08 May 2020; the initial directive included preparatory instructions to the public and ministries before the first case of COVID-19 was registered. Subsequently, three other presidential directives were established; two of these instituted lockdown measures while one instituted the first phase of releasing some lockdown measures. Soft policies identified in this review included guidelines (n=4); press releases (n=4) and mitigation measures. Three out of the four guidelines were clinical practice guidelines, these include quarantine of individuals in the context of containment of COVID-19, COVID-19 preparedness and response plan-laboratory manual, and national guidelines for management of COVID-19 patients.Conclusion: Uganda has experience built from response to previous epidemics. Uganda has robust policies in place to respond to COVID-19. Comprehensive Policies integrating human capital, research and economical aspects of an epidemic can increase and better prepare Uganda for future.