Assessment of the contribution of UGT1A gene polymorphisms to the development of cholelithiasis
E. V. Shreiner,
A. I. Khavkin,
M. S. Novikova
et al.
Abstract:Iron overload in non-alcoholic fatty liver disease (NAFLD) is a fairly common phenomenon that receives very little attention in clinical practice. However, iron overload, leading to hemosiderosis (deposition of “indigestible” nanodispersed iron oxides in various tissues) significantly aggravates NAFLD, stimulating increased chronic inflammation, insulin resistance and hemosiderosis of other organs. As a result, ferroptosis of hepatocytes occurs (apoptosis caused by iron overload and hemosiderosis), which accel… Show more
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