Assessment of the clinical efficacy of a hyaluronic acid-based deep wrinkle filler using new instrumental methods

Turlier, Virginie; Rouquier, Amandine; Black, David R.; Josse, Gwendal; Auvergnat, Arielle; Briant, Alain; Dahan, Serge; Gassia, V.; Saint-Martory, C.; Zakaria, Wassim; Queille‐Roussel, C.; Grognard-Gourdon, Catherine; Thioly-Bensoussan, D; Degouy, Arnaud; Schmitt, Anne-Marie

doi:10.3109/14764172.2010.502461

Cited by 17 publications

(22 citation statements)

References 17 publications

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“…Based on the results of the Turlier et al . study, it can be expected that the high degree of cross‐linking in Etermis ® 3 in combination with the free radical scavenging properties of mannitol acts in concert to limit early hydroxyl radical degradation of the product and contribute to its long‐lasting aesthetic effect.…”

Section: Discussionmentioning

confidence: 99%

“…We know from in vitro studies that in inflamed tissue the mechanism of HA degradation is predominantly via hydroxyl radicals and occurs at a fast rate during the initial inflammatory period [15]. Based on the results of the Turlier et al [34] study, it can be expected that the high degree of cross-linking in Etermis â 3 in combination with the free radical scavenging properties of mannitol acts in concert to limit early hydroxyl radical degradation of the product and contribute to its long-lasting aesthetic effect.…”

Section: Discussionmentioning

confidence: 99%

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Free radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: a literature review

André¹,

Villain

2017

Intern J of Cosmetic Sci

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Mannitol has both hydrating and antioxidant properties that make it an ideal excipient for use with hyaluronic acid (HA) fillers. This review examines the role of reactive oxygen species in the ageing process and their effects on both endogenous HA and HA products developed for aesthetic use. Evidence is presented to show that the free radical scavenging properties of mannitol provide it with a twofold mechanism of action when combined with HA fillers: reducing the inflammation and swelling associated with the injection procedure itself, and preventing the degradation of the injected HA by free radicals. Mannitol also has a long-and well-established safety profile in both the food and pharmaceutical industry. Having established the rationale for using mannitol in combination with an HA filler, the products using this strategy are then reviewed. The addition of mannitol to HA fillers is a viable and safe option for improving both short-and long-term HA aesthetic effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Free radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: a literature review

André¹,

Villain

2017

Intern J of Cosmetic Sci

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“…Moreover, another advantage of HA is that it is easily degraded by hyaluronidase. The HA filler used in this study, Glytone 3, consists of 23 mg/ml HA in phosphate buffer with mannitol14, which acts as both an antioxidant and a moisturizer15.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation

et al. 2014

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BackgroundRecent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed.ObjectiveThe present study was designed to examine the clinical and histologic effects of a new needle that incorporates an RF device for HA injections.MethodsA new intradermal needle RF device (INNOfill; Pacific Pharma, Korea) was assessed in the present study. In the animal arm, procollagen production was measured by using enzyme-linked immunosorbent assay, the filler volume was quantified by incorporating a dye with filler, and the filler distribution was assessed through the changes in tissue structure. In the human arm, the efficacy of the combination regimen was assessed by using the wrinkle severity rating scale (WSRS).ResultsIn the animal study, RF treatment increased procollagen production in a time-dependent fashion. The total volume was significantly increased with the RF treatment when compared with the filler injections alone, and lasted for up to 7 weeks after treatment. Additionally, the filler distribution was reduced in animals treated with RF when compared with the untreated group. In the human study, the nasolabial folds of subjects treated with RF before filler injections exhibited a significantly greater change in the WSRS score from baseline when compared with the nasolabial folds treated with filler injections alone.ConclusionA new device incorporating RF treatment before HA filler injection may represent a biocompatible and long-lasting advance in skin rejuvenation.

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“… Skin surface texture in crow's feet and infraorbital area measured by profilometry analysis of silicon replicas Evenness of texture assessed by an algorithm for image analysis on standardized digital photographs taken in cross‐polarized light and polarized parallel light. Overall skin condition assessed by subjects, using a visual analogue scale of 0‐10 (wrinkles, fine lines, radiance/brightness of complexion, skin firmness, uniformity/evenness of pigmentation). …”

Section: Methodsmentioning

confidence: 99%

Antiaging efficacy of a retinaldehyde‐based cream compared with glycolic acid peel sessions: A randomized controlled study

Rouvrais

Baspeyras²,

Mengeaud

et al. 2018

J of Cosmetic Dermatology

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Assessment of the clinical efficacy of a hyaluronic acid-based deep wrinkle filler using new instrumental methods

Abstract: This HA gel is well tolerated and provides a significant and long-lasting correction of moderate to severe NLFs, as objectively demonstrated by instrumental methods.

Cited by 17 publications

References 17 publications

Free radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: a literature review

Free radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: a literature review

The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation

Antiaging efficacy of a retinaldehyde‐based cream compared with glycolic acid peel sessions: A randomized controlled study

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