Assessment of the cerebellar neurotoxic effects of nicotine in prenatal alcohol exposure in rats

Bhattacharya, Dwipayan; Majrashi, Mohammed; Ramesh, Sindhu; Govindarajulu, Manoj; Bloemer, Jenna; Fujihashi, Ayaka; Crump, B J; High-tower, H.A.; Bhattacharya, Subhrajit; Moore, Timothy; Suppiramaniam, Vishnu; Dhanasekaran, Muralikrishnan

doi:10.1016/j.lfs.2017.12.010

Cited by 14 publications

(24 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Benjamini-Hochberg critical value for passing P values was P = .006. However, in contrast to PAE, these associations were seen at higher EEG frequencies, specifically in the right-central region (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36) Hz) and right-parietal region (28-39 Hz; 43-45 Hz) (…”

Section: Main Effect Of Smoking On Eeg Power In Active Sleepmentioning

confidence: 89%

See 1 more Smart Citation

Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Brain Activity

et al. 2020

View full text Add to dashboard Cite

IMPORTANCE Research to date has not determined a safe level of alcohol or tobacco use during pregnancy. Electroencephalography (EEG) is a noninvasive measure of cortical function that has previously been used to examine effects of in utero exposures and associations with neurodevelopment. OBJECTIVE To examine the association of prenatal exposure to alcohol (PAE) and tobacco smoking (PTE) with brain activity in newborns.

show abstract

Section: Main Effect Of Smoking On Eeg Power In Active Sleepmentioning

confidence: 89%

“…29 Recent evidence also suggests that PAE and PNE combined induce oxidative stress and increase monoamine oxidase activity and caspase expression in the cerebellum. 30 These…”

Section: Introductionmentioning

confidence: 99%

Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Brain Activity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…NADH oxidation to NAD⁺ is catalysed by mitochondrial Complex-I (NADH dehydrogenase). Tissue homogenate obtained from the testis of neonate, juvenile and adult groups was added to PBS and conversion of NADH to NAD⁺ was measured spectrophotometrically at 340 nm (Bhattacharya et al, 2018;Ramesh et al, 2018;Ramsay, Dadgar, Trevor, & Singer, 1986).…”

Section: Mitochondrial Complex-i Activitymentioning

confidence: 99%

“…Cytochrome C oxidation is catalysed by mitochondrial Complex-IV (Cytochrome C oxidase). Cytochrome C oxidation was spectrophotometrically measured in the testis of neonate, juvenile and adult groups at 550 nm (Bhattacharya et al, 2018;Ramesh et al, 2018;Ramsay et al, 1986;Wharton & Tzagoloff, 1967).…”

Section: Mitochondrial Complex-iv Activitymentioning

confidence: 99%

See 1 more Smart Citation

Augmented oxidative stress and reduced mitochondrial function in ageing goat testis

Majrashi

Fujihashi

Almaghrabi

et al. 2020

Veterinary Medicine & Sci

Self Cite

View full text Add to dashboard Cite

Recently, there is a significant increase in the commercial use of goat products. Nevertheless, there are very few reports on the characterization of redox biomarkers and mitochondrial function in the goat testis. Therefore, in this study we studied the markers of oxidative stress and mitochondrial functions in the goat testis during the process of ageing. Alterations in the markers of oxidative stress/redox biomarkers (contents of reactive oxygen species, nitrite, lipid peroxide, protein carbonyl, glutathione and activities of glutathione peroxidase, monoamine oxidase) and mitochondrial function (Complex‐I and Complex‐IV activities) were elucidated during the process of ageing. Augmented oxidative stress and decreased mitochondrial function were prominent during ageing in the goat testis. Ageing can lead to induction of oxidative stress and decreased production of ATP; however, the prooxidants generated must be effectively removed from the body by the innate antioxidant defence system to minimize the damage to the host tissue. Conversely, the antioxidants cannot completely scavenge the excessive amount of reactive oxygen species produced during ageing or pathological conditions leading to significant cell death and tissue damage. Thus, the use of effective and potent antioxidants in the feed could significantly reduce oxidative stress and improve mitochondrial function, resulting in enriched goat health.

show abstract

In Utero Exposure to Alcohol and Tobacco and Electroencephalogram Power During Childhood

Pini,

Sania,

Rao

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

ImportancePrenatal alcohol exposure (PAE) and prenatal tobacco exposure (PTE) are risk factors associated with adverse neurobehavioral and cognitive outcomes.ObjectiveTo quantify long-term associations of PAE and PTE with brain activity in early and middle childhood via electroencephalography (EEG).Design, Setting, and ParticipantsThis cohort study included participants enrolled in the Safe Passage Study (August 2007 to January 2015), from which a subset of 649 participants were followed up in the Environmental Influences on Child Health Outcomes Program. From September 2018 through November 2022, EEG recordings were obtained at ages 4, 5, 7, 9, or 11 years. Data were analyzed from November 2022 to November 2023.ExposuresMaternal self-reported consumptions of alcohol and tobacco during pregnancy were captured at the recruitment interview and at up to 3 visits during pregnancy (20-24, 28-32, and ≥34 weeks’ gestation). Classifications of PAE (continuous drinking, quit-early drinking, and nondrinking) and PTE (continuous smoking, quit-early smoking, and nonsmoking) were previously obtained.Main Outcomes and MeasuresEEG band powers (theta, alpha, beta, gamma) were extracted from the EEG recordings. Linear regression models were used to estimate the associations of PAE and PTE with EEG estimates.ResultsThe final sample included 649 participants (333 [51.3%] female) aged 4, 5, 7, 9, or 11 years. Children whose mothers were in the quit-early drinking cluster had increased alpha power (0.116 [95% CI, 0.023 to 0.209] μV2; P = .02) compared with individuals without PAE. The magnitude of this increase was approximately double for children exposed to continuous drinking (0.211 [95% CI, 0.005 to 0.417] μV2; P = .04). Children whose mothers were in the continuous smoking cluster had decreased beta power (−0.031 [95% CI, −0.059 to −0.003] μV2; P = .03) and gamma power (−0.020 [95% CI, −0.039 to −0.000] μV2; P = .04) compared with the nonsmoking cluster. In exploratory sex-stratified models, male participants in the quit-early PAE cluster had greater EEG power in the alpha band (0.159 [95% CI, 0.003 to 0.315] μV2; P = .04) compared with those with no PAE, and the difference was approximately double for male participants with continuous PAE (0.354 [95% CI, 0.041 to 0.667] μV2; P = .03). Male participants in the continuous PTE cluster had decreased beta (−0.048 [95% CI, −0.090 to − 0.007] μV2; P = .02) and gamma (−0.032 [95% CI, −0.061 − 0.002] μV2; P = .04) power compared with those with no PTE.Conclusions and RelevanceThese findings suggest that even low levels of PAE and PTE were associated with long-term alterations of brain activity.

show abstract

Assessment of the cerebellar neurotoxic effects of nicotine in prenatal alcohol exposure in rats

Cited by 14 publications

References 68 publications

Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Brain Activity

Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Brain Activity

Augmented oxidative stress and reduced mitochondrial function in ageing goat testis

In Utero Exposure to Alcohol and Tobacco and Electroencephalogram Power During Childhood

Contact Info

Product

Resources

About