Assessment of the Association between Neuropeptide Y and Chronic Kidney Disease Progression

Ezzat, Haitham; Saeed, Saeed Abdel Wahab; Abouelsaad, Hend Ahmed; Teama, Nahla Mohamed

doi:10.21608/ejhm.2020.105926

Cited by 1 publication

(3 citation statements)

References 11 publications

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“…Zoccali et al [60] and Ezzat et al [23] showed that greater serum creatinine was associated with increased serum NPY and decreased glomerular filtration rate. Moreover, increased voluntary intake and energy balance correlated with decreased NPY levels [50,61].…”

Section: Discussionmentioning

confidence: 99%

“…Neuropeptide Y (NPY) is a co-transmitter of the sympathetic nervous system including the renal nerves. The kidney expresses NPY receptors, which can also be activated by peptide YY (PYY), a postprandial circulating hormone released from gastrointestinal cells [16,22,23,51]. Despite the profound reductions of renal blood flow, systemic NPY infusion can cause diuresis and natriuresis; this occurs largely independently of the pressure natriuresis mechanisms and is possibly mediated by an extrarenal Y5 receptor.…”

Section: Discussionmentioning

confidence: 99%

“…Activation of NPY receptors in the brain increases feeding intake and may affect kidney function, causing a vasoconstrictor effect on the renal vasculature and a decrease in renal blood flow [17][18][19][20][21][22][23]. Renal activity in animals can be evaluated with the use of clearance methods, in which endogenous creatinine can be used as a testing substance to determine the level of glomerular filtration [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Creatinine as a Urinary Marker of the Purine Derivatives Excretion in Urine Spot Samples of Lambs Fed Peach Palm Meal

Pereira

Carvalho

et al. 2022

Animals

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The objective was to evaluate the influence of diets on lambs using different levels of peach palm meal as a replacement for maize (0, 10, 40, 60, and 85% of diet dry matter) on the endogenous creatinine clearance (CC), urine concentration ratio of purine derivatives to creatinine (PDC index), and daily creatinine excretion (DCE) as a marker to estimate purine derivatives (PD) excretion from urinary spot samples collected at different time points (4, 8, 12, 16, 20, 24 h after morning feeding) compared to 24-h total urine collection. The measured parameters were voluntary intake, urinary volume, CC, DCE, the concentration of plasma creatinine, and PD and purine derivatives’ excretion (PDE). Five lambs were allocated to metabolic cages and distributed in a 5 × 5 Latin square. Urine collection was taken daily on days 16 to 19 of each experimental period. The inclusion of peach palm meal linearly reduced the intake of dry matter (g kg BW−0.75, p = 0.005), crude protein (g kg BW−0.75, p = 0.010), metabolizable energy (MJ kg BW−0.75, p = 0.010) and CC (p < 0.0001). It also quadratically affected the urinary volume (p = 0.008) and DCE (p = 0.004). There was a linear decrease for PDC index (p = 0.032) and PDE (p < 0.0001) measured in the 24-h total urine with peach palm meal levels. The different times of spot urine sampling did not affect (p > 0.05) the PDC index and PDE. Peach palm meal decreases the CC thereby compromising the use of a mean value of DCE as a PDE marker in spot urine samples. There is greater accuracy when using different values of DCE obtained for each diet as markers for the PDE in spot urine samples. Unconventional foodstuffs of low palatability affecting the voluntary intake of feed change the renal function.

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